by rss feed | Aug 19, 2026 | anti-aging, David Sinclair, News Feeds, Reprogramming
I’ve been debating whether to unfollow longevity enthusiasts David Sinclair and Bryan Johnson on X. I find their posts about various anti-aging efforts to be fascinating on one level but also very unsettling. For one thing, some posts seem close to medical...
by rss feed | Feb 11, 2026 | David Sinclair, ER-100, gene therapy, News Feeds, partial reprogramming, Reprogramming
The FDA has cleared a trial of ER-100 from Life Biosciences for eye rejuvenation. In the trial, ER-100 will deliver inducible expression of the three reprogramming factors. Oct-4, Sox-2, and Klf-4 are colloquially known together as OSK. This trial is an extension of...
by rss feed | Oct 1, 2025 | Altos Labs, in vivo reprogramming, News Feeds, Reprogramming
Lately, we’ve been hearing more about something called “in vivo reprogramming.” It comes up frequently in the longevity space. Today’s post explains this cutting-edge area of research and its hoped-for, potential clinical applications....
by rss feed | Aug 31, 2025 | chemical reprogramming, News Feeds, Reprogramming, weekly reads
After Hongkui Deng first reported chemical reprogramming with mouse cells more than ten years ago, I thought that this approach might overtake genetic approaches for making iPS cells. That hasn’t happened. As much as using chemical cocktails allows for iPS cell...
by rss feed | Sep 20, 2023 | cellular rejuvenation, cellular reprogramming, epigenetic reprogramming, Informational, News Feeds, Reprogramming
Epigenetic reprogramming is a term used in cell biology that is increasingly ending up in news stories too. Unfortunately, some folks, especially in the cellular rejuvenation and anti-aging space, are getting this term and other things confused. Just to start off,...
by rss feed | Jan 15, 2023 | News Feeds, Reprogramming, reprogramming aging, weekly reads
Let’s start with a couple of new pieces on in vivo reprogramming. The idea here is to do something like making iPS cells but doing it inside organisms and not quite pushing cells all the way back to pluripotency. Just younger, healthier cells. Why do that? The...
