ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for Recessive Dystrophic Epidermolysis Bullosa treatment

by rss feed | Feb 20, 2021 | News Feeds, REGENERATIVE MEDICINE

Schema of ABCB5+ dermal MSCs (DSCs) characteristics compared to BM‐MSCs. Potential mechanisms of superior skin homing of ABCB5+ DSCs for use in RDEB and regenerative medicine applications. Similarities in immunomodulatory capacity of ABCB5+ DSCs and BM‐MSCs are shown...

Potential applications of deep learning in single‐cell RNA sequencing analysis for cell therapy and regenerative medicine

by rss feed | Feb 15, 2021 | News Feeds, REGENERATIVE MEDICINE

The strategy of deep learning on scRNA‐seq data. Abstract When used in cell therapy and regenerative medicine strategies, stem cells have potential to treat many previously incurable diseases. However, current application methods using stem cells are underdeveloped,...

Suppressing Hippo signaling in the stem cell niche promotes skeletal muscle regeneration

by rss feed | Feb 2, 2021 | News Feeds, REGENERATIVE MEDICINE

Our AAV9 Salvador shRNA strategy recreates a myofiber‐guided regenerative stem cell niche and promotes simultaneous myogenesis and angiogenesis‐neovascularization for the functional recovery of skeletal muscles in ischemic extremities. These myofibers release...

A human induced pluripotent stem cell‐based modular platform to challenge sensorineural hearing loss

by rss feed | Feb 1, 2021 | News Feeds, REGENERATIVE MEDICINE

Schematic of the various applications of induced pluripotent stem cell (IPSC) modular platform to challenge sensorineural hearing loss. IPSCs can be generated via genetic reprogramming of somatic cells from patient/healthy subject. In the inner ear, this technology...

HC‐HA/PTX3 from amniotic membrane reverts senescent limbal niche cells to Pax6+ neural crest progenitors to support limbal epithelial progenitors

by rss feed | Jan 13, 2021 | News Feeds, REGENERATIVE MEDICINE

Reversal of late passaged limbal niche stromal cells to Pax6+ neural crest progenitors by HC‐HA/PTX3. Abstract Quiescence and self‐renewal of human corneal epithelial progenitor/stem cells (LEPC) are regulated by the limbal niche, presumably through close interaction...

Recommended regenerative medicine reads: making eggs, retraction, freezing, more

by rss feed | Dec 20, 2020 | extracellular vesicles, freezing cells, News Feeds, REGENERATIVE MEDICINE, Reprogramming, stem cells, Weekend Reads

What to read when there are almost an endless number of stem cell and regenerative medicine pubs? Here are some suggestions including what I would say is a very unusual Nature paper on making egg cells from stem cells. If this could be done safely with human cells all...