Human induced pluripotent stem cell‐derived macrophages ameliorate liver fibrosis

by rss feed | Dec 5, 2021 | News Feeds, REGENERATIVE MEDICINE

Human induced pluripotent stem cells (iPSCs) are efficiently differentiated into both M1 and M2 macrophages. These cells were used to treat liver fibrosis in an immunodeficient mouse model. This treatment led to improvement in the fibrosis as measured by several...

Engineered human cardiac microtissues: The state‐of‐the‐(he)art

by rss feed | Mar 31, 2021 | News Feeds, REGENERATIVE MEDICINE

Recent advances in cardiac microtissue engineering with a focus on approaches to recapitulate the adult heart and model disease phenotype. The microtissue platform depicted may not be representative of platform used in selected publication and is only a...

Mitochondrial transfer from MSCs to macrophages restricts inflammation and alleviates kidney injury in diabetic nephropathy mice via PGC‐1α activation

by rss feed | Mar 19, 2021 | News Feeds, REGENERATIVE MEDICINE

MSCs transfered mitochondria to Mφ, which elicited Mφ into anti‐inflammatory phenotype and ameliorated kidney injury through activation of PGC‐1α. Abstract Mesenchymal stem cells (MSCs) have fueled ample translation for treatment of immune‐mediated diseases. Our...

Gap junction‐mediated cell‐cell interaction between transplanted mesenchymal stem cells and vascular endothelium in stroke

by rss feed | Mar 11, 2021 | News Feeds, REGENERATIVE MEDICINE

Ten minutes after BCECF‐loaded mesenchymal stem cells transplantation, the expression of connexin 37 were observed in the cell membrane of endothelial cells which are adjacent to the transferred BCECF signal at nuclei/cytosol of the cells. Abstract We have shown...

ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for recessive dystrophic epidermolysis bullosa treatment

by rss feed | Feb 20, 2021 | News Feeds, REGENERATIVE MEDICINE

Schema of ABCB5+ dermal mesenchymal stem cell (MSC) (DSC) characteristics compared to bone marrow (BM)‐MSCs. Potential mechanisms of superior skin homing of ABCB5+ DSCs for use in recessive dystrophic epidermolysis bullosa (RDEB) and regenerative medicine...

ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for Recessive Dystrophic Epidermolysis Bullosa treatment

by rss feed | Feb 20, 2021 | News Feeds, REGENERATIVE MEDICINE

Schema of ABCB5+ dermal MSCs (DSCs) characteristics compared to BM‐MSCs. Potential mechanisms of superior skin homing of ABCB5+ DSCs for use in RDEB and regenerative medicine applications. Similarities in immunomodulatory capacity of ABCB5+ DSCs and BM‐MSCs are shown...