Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme‐2 and masR receptor‐dependent

by rss feed | Jun 22, 2021 | News Feeds, REGENERATIVE MEDICINE

Angiotensin converting enzyme-2 (ACE-2) contributes to human placenta mesenchymal stem cell (hPMSC)-induced protection against ischemic injury through MasR pathway. Abstract Thromboembolic stroke remains a major cause of neurological disability and death. Current...

Macrophages at the nexus of mesenchymal stromal cell potency: The emerging role of chemokine cooperativity

by rss feed | Mar 31, 2021 | News Feeds, REGENERATIVE MEDICINE

The mesenchymal stromal cell (MSC) and macrophage dyad theorem. MSCs polarize macrophages to an interleukin (IL)-10 anti-inflammatory and regenerative functionality via secretome containing heteroplexed chemokines (and other active factors) or efferocytosis. Both...

Bone marrow‐derived mesenchymal stem cells improve rat islet graft revascularization by upregulating ISL1

by rss feed | Mar 23, 2021 | News Feeds, REGENERATIVE MEDICINE

This study demonstrated that bone marrow-derived mesenchymal stem cells (BMSCs) led to an increase in insulin gene enhancer binding protein-1 (ISL1) expression in islets and improved the vascular remodeling after islet transplantation in an animal model. Furthermore,...

Mitochondrial transfer from mesenchymal stem cells to macrophages restricts inflammation and alleviates kidney injury in diabetic nephropathy mice via PGC‐1α activation

by rss feed | Mar 19, 2021 | News Feeds, REGENERATIVE MEDICINE

MSCs transfered mitochondria to Mφ, which elicited Mφ into anti-inflammatory phenotype and ameliorated kidney injury through activation of PGC-1α. Abstract Mesenchymal stem cells (MSCs) have fueled ample translation for treatment of immune-mediated diseases. Our...

Gap junction‐mediated cell‐cell interaction between transplanted mesenchymal stem cells and vascular endothelium in stroke

by rss feed | Mar 11, 2021 | News Feeds, REGENERATIVE MEDICINE

Ten minutes after BCECF-loaded mesenchymal stem cells transplantation, the expression of connexin 37 were observed in the cell membrane of endothelial cells which are adjacent to the transferred BCECF signal at nuclei/cytosol of the cells. Abstract We have shown...

ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for recessive dystrophic epidermolysis bullosa treatment

by rss feed | Feb 20, 2021 | News Feeds, REGENERATIVE MEDICINE

Schema of ABCB5+ dermal mesenchymal stem cell (MSC) (DSC) characteristics compared to bone marrow (BM)-MSCs. Potential mechanisms of superior skin homing of ABCB5+ DSCs for use in recessive dystrophic epidermolysis bullosa (RDEB) and regenerative medicine...