Extracellular vesicles derived from fibroblasts promote wound healing by optimizing fibroblast and endothelial cellular functions

by rss feed | Dec 8, 2020 | News Feeds, REGENERATIVE MEDICINE

This study demonstrated that fibroblast derived extracellular vesicle (EV), induced activation of fibroblast, endothelial cell migration, and tube formation in vitro and also induced, in vivo wound healing by enhancing the collagen formation and maturation, increasing...

Fibulin 5, a human Wharton’s jelly‐derived mesenchymal stem cells‐secreted paracrine factor, attenuates peripheral nervous system myelination defects through the Integrin‐RAC1 signaling axis

by rss feed | Dec 2, 2020 | News Feeds, REGENERATIVE MEDICINE

The common pathological symptom of dysmyelinating and demyelinating diseases is uncompact myelin ensheathments of the axons. Our findings suggest that FBLN5 binds to the Integrin receptors and promotes actin remodeling through RAC1 activation in the Schwann cells....

IRF7 suppresses hematopoietic regeneration under stress via CXCR4

by rss feed | Nov 30, 2020 | News Feeds, REGENERATIVE MEDICINE

Abstract Hematopoietic stem cells (HSCs) maintain quiescence under steady state; however, they are compelled to proliferate and expand to replenish the blood system under stress. The molecular basis underlying stress hematopoiesis remains to be fully understood. In...

Adipose stem cell secretome markedly improves rodent heart and human induced pluripotent stem cell‐derived cardiomyocyte recovery from cardioplegic transport solution exposure

by rss feed | Nov 7, 2020 | News Feeds, REGENERATIVE MEDICINE

The damaging effects of University of Wisconsin (UW) solution are ameliorated by the inclusion of adipose‐derived stem/stromal cell secretome (ASC‐S). Mouse hearts stored in UW supplemented with ASC‐S demonstrated increased survivability ex vivo. This same phenomenon...

Exosome‐educated macrophages and exosomes differentially improve ligament healing

by rss feed | Nov 3, 2020 | News Feeds, REGENERATIVE MEDICINE

Exosome‐educated macrophages (EEMs) and exosomes differentially improve ligament healing. EEM treatment to an injured rat medial collateral ligament resulted in reduced inflammation and improved ligament strength. In contrast, exosome treatment reduced scar size, and...