by rss feed | Jan 4, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
Our model depicts the damage induced by STp on the intestinal mucosal epithelial integrity via the inhibition of intestinal stem cells (ISCs). STp reduced ISC activity, inhibited epithelial cell (IEC) proliferation, and differentiation, and induced IEC apoptosis...
by rss feed | Dec 30, 2020 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
Human satellite cells isolated from gluteus maximus muscle denervated >20 years retain the ability to engraft and form new muscle fiber when transplanted into NOD.Cg‐Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice, and also reoccupy the anatomic niche. Left: NSG muscle...
by rss feed | Dec 24, 2020 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
CCAAT/enhancer‐binding protein beta (C/EBPβ) promotes muscle satellite cell quiescence. (A) In resting muscle, satellite cells are quiescent and express both PAX7 and C/EBPβ. C/EBPβ promotes the expression of several quiescence‐associated genes including Cav1. (B)...
by rss feed | Dec 22, 2020 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
Although mesenchymal stem/stromal cells (MSCs) are promising for cell therapy, long‐term culture leads to MSC senescence with reduced stem cell capacity. We showed that FZD5, which is specifically expressed in immature MSCs, can serve as a stemness indicator....
by rss feed | Dec 12, 2020 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
This study identified a heterogeneous population of myeloid progenitors in the leptomeninges of adult mice, which gave rise to all major myelo‐erythroid lineages in clonogenic assays. Lineage tracing and bone marrow transplantation showed that the progenitors were...
by rss feed | Dec 9, 2020 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
Calcitonin receptor (CalcR)‐mutant muscle stem cells ectopically express delta‐like non‐canonical Notch ligand 1 (Dlk1). The Dlk1 expression marks all non‐quiescent muscle stem cells in CalcR‐mutant muscle stem cells. The loss of Dlk1 rescues the impaired quiescent...
