A case for revisiting Nodal signaling in human pluripotent stem cells

by rss feed | May 1, 2021 | CONCISE REVIEW, News Feeds

Hayes et al discuss the implications of recent advances in our understanding of Nodal signaling for the maintenance and self‐renewal of human pluripotent stem cells. Abstract Nodal is a transforming growth factor‐β (TGF‐β) superfamily member that plays a number of...

Organoid technology: Current standing and future perspectives

by rss feed | Mar 31, 2021 | CONCISE REVIEW, News Feeds

Organoid generation and therapeutic potential. Abstract Organoids are powerful systems to facilitate the study of individuals' disorders and personalized treatments. This emerging technology has improved the chance of translatability of drugs for preclinical therapies...

Macrophages at the nexus of mesenchymal stromal cell potency: The emerging role of chemokine cooperativity

by rss feed | Mar 31, 2021 | CONCISE REVIEW, News Feeds

The mesenchymal stromal cell (MSC) and macrophage dyad theorem. MSCs polarize macrophages to an interleukin (IL)‐10 anti‐inflammatory and regenerative functionality via secretome containing heteroplexed chemokines (and other active factors) or efferocytosis. Both...

Mesenchymal stromal cell‐mediated immune regulation: A promising remedy in the therapy of type 2 diabetes mellitus

by rss feed | Feb 23, 2021 | CONCISE REVIEW, News Feeds

Activated mesenchymal stromal cells (MSCs) and apoptotic MSCs exert potent immunoregulatory effects mainly via secretome, thus modulating the functions of various immune cells. MSC‐mediated immunomodulation contributes to Type 2 diabetes mellitus therapies via...

Potential applications of deep learning in single‐cell RNA sequencing analysis for cell therapy and regenerative medicine

by rss feed | Feb 15, 2021 | CONCISE REVIEW, News Feeds

The strategy of deep learning on scRNA‐seq data. Abstract When used in cell therapy and regenerative medicine strategies, stem cells have potential to treat many previously incurable diseases. However, current application methods using stem cells are underdeveloped,...

Engineering‐inspired approaches to study β‐cell function and diabetes

by rss feed | Jan 26, 2021 | CONCISE REVIEW, News Feeds

Engineered in vitro systems have the potential to revolutionize our understanding metabolic diseases and the countless roles β‐cells play in them. Many different sources of insulin‐secreting cells are available for engineered systems each with their own strengths and...