by rss feed | Dec 5, 2021 | CONCISE REVIEW, News Feeds
Our review focuses on the cardiac extracellular matrix (ECM) and cardiac fibroblasts (CFs), cardiac-derived progenitor cells (CPCs), and mesenchymal stem cells (MSCs), and their constant interplay in response to tissue development, aging, disease progression, and...
by rss feed | Dec 5, 2021 | CONCISE REVIEW, News Feeds
Cardiovascular disease is the primary cause of death around the world. For almost two decades, cell therapy has been proposed as a solution for heart disease. In this article, we report on the “state-of-play” of cellular therapies for cardiac repair and regeneration....
by rss feed | Dec 5, 2021 | CONCISE REVIEW, News Feeds
Schematic diagram illustrating the major brain regions affected in neurodegenerative diseases, to which EVs actively migrate following IN administration. The figure presents the key mechanisms and cargo used by MSC-derived EVs to mitigate these pathologies and induce...
by rss feed | Dec 5, 2021 | CONCISE REVIEW, News Feeds
Cartoon illustrating the contribution of Nups to epigenetic mechanisms in stem cells. (1) Transcription. (2) Heterochromatin formation. (3) Silencing. (4) Topological associated domain formation. (5) miRNA biogenesis and transport. (6) Protein SUMOylation. Abstract...
by rss feed | Dec 5, 2021 | CONCISE REVIEW, News Feeds
Bromodomain protein 4 (BRD4) mediated transcription elongation in complex gene regulatory network during different stages of stem cell transitions. BRD4 modulates gene expression by recruiting PTEF-b for successful RNA polymerase II pause release and transcriptional...
by rss feed | Dec 5, 2021 | CONCISE REVIEW, News Feeds
Schematic diagram of stem-cell derived two-dimensional schizophrenia (SCZ) culture models (left column) vs three-dimensional (3D) SCZ brain organoid models (middle column) to engineer neural networks for translational medicine. SCZ patient cells are reprogrammed...
