Aryl hydrocarbon receptor controls skin homeostasis, regeneration, and hair follicle cycling by adjusting epidermal stem cell function

by rss feed | Dec 5, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

Aryl hydrocarbon receptor (AhR) is required for skin homeostasis and hair growth. AhR depletion in keratinocytes and dermal fibroblasts compromises skin regeneration likely because of reduced epidermal stem cells (EpdSCs) numbers. Reconstitution assays suggest a cell...

Dopamine regulates adult neurogenesis in the ventricular‐subventricular zone via dopamine D3 angiotensin type 2 receptor interactions

by rss feed | Dec 5, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

Model of the effects of dopamine in the proliferation of ventricular-subventricular zone cells. Dopamine, via D2-like receptors, upregulates angiotensin AT2 receptor expression, which mediates D2-induced cell proliferation. Dopamine, through D1-like receptors,...

ELF3 mediates IL‐1α induced differentiation of mesenchymal stem cells to inflammatory iCAFs

by rss feed | Dec 5, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

Mesenchymal stem cells are a progenitor of myofibroblasts and inflammatory carcinoma-associated fibroblasts. The present study identifies ELF3 as an essential transcription factor in the differentiation of this key pro-inflammatory stromal cell type. Abstract Stromal...

Increased lipogenesis is critical for self‐renewal and growth of breast cancer stem cells: Impact of omega‐3 fatty acids

by rss feed | Dec 5, 2021 | cancer stem cells, News Feeds

Breast cancer stem cells (BCSC) have a distinct fatty acid profile due to the aberrant expressions of lipogenic enzymes (eg, FAS, SCD1, and FADS1/2), which are highly involved in sustaining their self-renewal, and proliferative capabilities. Omega-3 polyunsaturated...

Spatiotemporal extracellular matrix modeling for in situ cell niche studies

by rss feed | Dec 5, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

Spatiotemporal extracellular matrix modeling facilitates the identification of cell-niches by combining decellularized whole organ sections and recellularization with a new algorithm for automatic generation of density maps and cluster-analysis for identification of...