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Osteoblastic Wntless deletion differentially regulates the fate and functions of bone marrow‐derived stem cells in relation to age

by rss feed | Oct 21, 2020 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

We investigated age‐related impacts of osteoblastic Wls deficiency on bone marrow (BM) and on the functions of BM‐conserved stem cells. Wls deletion in Col2.3‐expressing cells induces oxidative stress and senescence of bone marrow stromal cells (BMSCs) and impairs BM...

Stem cell contributions to cementoblast differentiation in healthy periodontal ligament and periodontitis

by rss feed | Oct 16, 2020 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

During homeostasis, two cells populations (Axin2+ and CD90+ cells) differentiate into cementoblasts in the periodontium. In adults, only Axin2+ cells continue contributing to cementoblast formation, whereas CD90+ cells are not necessary during adult homeostasis....

In Lyl1−/− mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues

by rss feed | Oct 13, 2020 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

In Lyl1‐deficient mice, the impaired vascular compartment of the adipose niche promotes triggering of adipose stem cell (ASC) differentiation, leading to premature ASC depletion, early adipocyte expansion, and overweight. In Lyl1‐deficient mice, the vascular...
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