by rss feed | Feb 20, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
Lysosomes are more abundant in neural stem‐progenitor cells (NPCs) than in differentiating neurons in the developing mouse telencephalon. TFEB and TFE3, master regulators of lysosomal biosynthesis, as well as Slc15a4, a lysosomal transporter associated with systemic...
by rss feed | Feb 20, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
Abstract Lysosomes have recently been implicated in regulation of quiescence in adult neural stem cells (NSCs). Whether lysosomes regulate the differentiation of neural stem‐progenitor cells (NPCs) in the embryonic brain has remained unknown, however. We here show...
by rss feed | Feb 13, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
Kidney derived urine stem cells are equipped to provide B cells survival signals, promoting their activation, proliferation, and antibody production. Molecular phenotype and supernatant analysis revealed that USCs express the adhesion molecule ICAM‐1 and secrete B...
by rss feed | Feb 6, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
SMAD‐specific E3 ubiquitin protein ligase 2 (Smurf2) transcription is regulated by activating transcription factor 4‐induced endoplasmic reticulum stress, and Smurf2 negatively regulates pentraxin 3 (PTX3) stability in ankylosing spondylitis mesenchymal stem cells and...
by rss feed | Feb 5, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
Megakaryopoiesis and thrombopoiesis can be regulated via O‐GlcNAc/c‐Myc axis. Inhibition of O‐GlcNAcylation, which also occurs spontaneously during megakaryocyte differentiation, downregulates c‐Myc at posttranslational level via the promotion of c‐Myc ubiquitination...
by rss feed | Feb 5, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS
Megakaryopoiesis and thrombopoiesis can be regulated via O‐GlcNAc/c‐Myc axis. Inhibition of O‐GlcNAcylation, which also occurs spontaneously during megakaryocyte differentiation, downregulates c‐Myc at posttranslational level via the promotion of c‐Myc ubiquitination...
