by rss feed | Jan 11, 2024 | Andre Terzic, Cardiopoiesis, Heart Disease, journal club, News Feeds, stem cells for heart disease
One of the first regenerative medicine talks I ever saw was on stem cells for heart disease. I was still a trainee at the time. The professor, whom I won’t name, presented data from an early phase trial reporting that direct injections of some kind of cells...
by rss feed | Feb 7, 2023 | Aging, anti-aging, Dr. Davis Sinclair, journal club, News Feeds
About twenty years ago a science story made big news of a so-called anti-aging Methuselah gene. Methuselah gene and anti-aging The claim was that this DNA conferred long life on people. Hence the name Methuselah, which refers to a man from the Bible who reportedly...
by rss feed | Nov 3, 2022 | Direct Biologics, ExoFlo, FDA, FDA IND, journal club, News Feeds
I wrote recently about how political pressure on FDA Commissioner Stephen Hahn in 2020 may have helped the Texas firm Direct Biologics move their product ExoFlo forward inside the agency. Today I analyze the ExoFlo Phase I clinical trial paper used in that push on...
by rss feed | Sep 8, 2022 | direct reprogramming, journal club, News Feeds, transdifferentiation
There was a time when I thought transdifferentiation based approaches might quickly move into clinical trials. Then things kind of cooled off. We didn’t see many papers reporting methods to transdifferentiate cells. I still think that this technology, sometimes...
by rss feed | May 11, 2022 | Aging, brain, journal club, News Feeds, Young blood
A new Nature paper argues that young CSF fights brain aging. Young CSF vs. young blood CSF is the cerebrospinal fluid that surrounds the brains of young mice. The claim is that when young CSF is injected into the brain cavity of old mice, it makes the aged brains seem...
