Enteric mesenchymal cells support the growth of postnatal enteric neural stem cells

by rss feed | May 2, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

This study identifies that mesenchymal non‐neural crest‐derived cells (NNCDCs) from the postnatal intestine act as supporting cells to enteric neural crest‐derived cells (ENCDCs) and enhances ENCDC expression of neural stem cell markers. These properties can be...

Lef‐1 controls cell cycle progression in airway basal cells to regulate proliferation and differentiation

by rss feed | May 1, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

Airway basal stem cells utilize Lef‐1 to regulate the expression of certain DNA damage response (DDR) genes, including Chek1, and facilitate proper G1/S checkpoint cell cycle progression required for self‐renewal and differentiation (left panel). Mouse tracheal...

Cell‐intrinsic Wnt4 promotes hematopoietic stem and progenitor cell self‐renewal

by rss feed | Apr 29, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

Hematopoietic cell‐intrinsic Wnt4 promotes stem cell expansion and self‐renewal. Wnt4‐deficient (Wnt4Δ/Δ) stem cells display decreased lymphoid potential, increased mitochondrial superoxide and stress‐associated JNK activity, and cell cycle perturbations, including...

An aged bone marrow niche restrains rejuvenated hematopoietic stem cells

by rss feed | Apr 13, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

Model of the influence of the niche on old rejuvenated hematopoietic stem cells (HSCs). Old HSCs can be rejuvenated by Cdc42 activity inhibition, and maintain this youthful function when transplanted in young niches. In contrast, when they encounter an aged niche,...

Label‐free quality control and identification of human keratinocyte stem cells by deep learning‐based automated cell tracking

by rss feed | Mar 30, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

A deep learning‐based automated cell tracking (DeepACT) technology enables the evaluation of keratinocyte culture quality and the identification of keratinocyte stem cells using quantitative cell motion analysis. DeepACT comprises two main modules: identifying human...

Characterization of highly proliferative decidual precursor cells during the window of implantation in human endometrium

by rss feed | Mar 25, 2021 | News Feeds, TISSUE‐SPECIFIC STEM CELLS

Embryo implantation requires intensive tissue remodeling of the midluteal endometrium, driven by differentiation of resident stromal cells into decidual cells, uterine NK (uNK) cell‐mediated clearance of acute senescent decidual cells, and transvascular migration and...