From 1908 when their existence was first hypothesized and the name “Stem Cell” was coined, it was then 70 years before definitive proof of their existence was shown in 1978. In the decades since then, research employing Stem Cells as treatments and therapies has exploded off the charts with research being conducted on nearly all the continents. The staff at StemCell101.com is dedicated to combing the internet, trade journals, and medical publications to bring consumers the latest information and news about this exciting and promising field.

stemcell-research 

The following are just some examples of the Worldwide Research Effort:

AFRICA

South Africa
In March 2012 scientists at South Africa’s Council for Scientific and Industrial Research (CSIR) set up a facility for biomedical stem cell technology. Its gene expression and biophysics group generated the first induced pluripotent stem cells (iPSCs) in Africa, the CSIR announced.

ASIA

China
China holds unrestrictive policies in regard to embryonic stem cell research – one of the most unrestrictive in the world. With this atmosphere Chinese scientists who have been educated and been trained in the West have flocked back to set up stem cell research laboratories in their home country. Stem cell researchers in the West attest to the fact that stem cell research facilities and researchers in China are already world class.

India
In Bangalore, India, the Institute for Stem Cell Biology and Regenerative Medicine (inStem) has state-of-the-art research facilities. Research at inStem includes stem cell biology, looking into mechanism that control differentiation and renewal, and impact of stem cells on recovery from stroke. Also in India, the Chaitanya Stem Cell Centre gives information on neurology, kidney, liver and many untreatable diseases. It also pushes regenerative medicine..

Japan
The following report is derived from the editorial. “New horizon in stem cell research,” of The Japan Times, February 3,2014 issue. Dr. Haruko Obokata and her team have found that body cells taken from mice can be reprogrammed into stem cells by exposing them to low-PH acid liquids. This new way of reprogramming adult cells into pluripotent cells (embryonic stem cells) is called “stimulus-triggered acquisition of pluripotency” or STAP. The STAP method is easier than that used by Dr. Shinya Yamanaka of Kyoto University, co-recipient with Sir John Gurdon of the Nobel Prize in Physiology or Medicine in 2012. In 2006 Yamanaka produced embryonic stem cells out of mouse skin by introducing four genes as growth factors. The cells are called induced pluripotent stem cells (iPSC). Yamanaka and his team did the same on human skin cells in 2007. STAP cells can form placenta which iPSC cannot do. “It is hoped that more efforts will be made so that the discovery will lead to the advancement of regenerative medicine.”

South Korea
The Stem Cell Research Center (SCRC) is a government-funded organization that supports stem cell research.The SCRC acts is a funding agency with 52 projects throughout South Korea. A national network, the Korean Society for Stem Cell Research, has been set up to facilitate stem cell research. The Stem Cell Research Center is the biggest stem cell center supported by Ministry of Science and Technology. Several other centers are supported by ministries like the Ministry of Health and Welfare. Several non-government organizations support stem cell research.

stemcellresearch-australiaAUSTRALIA

Some stem cell research trials being conducted in Australia include…..

[lists bullet=”square” type=”style1″]

  • Condition: Graft Versus Host Disease. Mesenchymal Stromal Cells for Acute Graft Versus Host Disease. The trial plans to enrol 66 patients by December 2015 and to be completed by December 2016.
  • Condition: Osteoarthritis. HiQCell Joint Registry in Patients with Osteoarthritis Following the HiQCell Procedure. The first patients underwent this procedure in July 2012.
  • Condition: Brain tumours. Gene Therapy and Chemotherapy for the Treatment of Childhood Brain Tumours. The trial commenced in July 2012.
  • Condition: Bone repair. Cranial Reconstruction Using Mesenchymal Stromal Cells and Resorbable Biomaterials. This trial is conducted at the Royal Perth Hospital in Western Australia from January 2013 to December 2015.
  • Condition: Leukaemia. Pilot Study of Partially Human Leucocyte Antigen-Mismatched Stem Cell Infusions after Chemotherapy for Acute Myeloid Leukaemia.
  • Condition: Osteoarthritis. The Osteoarthritis Stem Cell Advanced Research Study. This trial is conducted by the Rheumatology Department of the Royal North Shore Hospital St Leonards in New South Wales and Regeneus Pty Ltd. (Internet. March 10,2014)

[/lists]

EUROPE

Belgium
Belgian medical researchers succeeded in repairing bones using stem cells from fatty tissue.

The Saint Luc university clinic hospital in Brussels has a team that “has treated 11 patients, eight of them children, with fractures or bone defects that their bodies could not repair….” This was reported by the university on January 14, 2014. The breakthrough technique of Saint Luc’s centre for tissue and cellular therapy consists in removing a “sugar cube sized piece of fatty tissue from the patient, a less invasive process than pushing a needle into the pelvis and with a stem cell concentration they say is some 500 times higher.”

France
“The national assembly of France has voted to a lift a ban on embryonic stem cell research, which could pave the way for crucial scientific developments.” (France lifts its ban on embyonic stem cell reserch by Rebecca Taylor | Paris, France | LifeNews.com | 7/17/13)

I-Stem is the largest French laboratory for research and development devoted to embryonic origin obtained by reprogramming gene. It is a collaboration between Inserm – National Institute of Health and Medical Research – and AFM-Telethon – French Association against Myopathies.

Germany
Germany defines stem cell research as “the scientific study of embryonic, fetal, adult, as well as induced pluripotent stem cells of living organisms of all kinds. By definition, stem cells are cells that are not yet fully developed and therefore have the potential to differentiate into different cell types.” In the medical and biological fields findings in stem cell research are obtained and turned to benefit consumers. The ultimate goal is regenerating defective organs.

Spain
Spain has a comprehensive regulatory framework for stem cell research, consisting of laws and regulations on stem cell research. One partner in research is the Centre for Genomic Regulation. This is reported by “Regulation of stem cell research in Spain,” updated in August 2012.

United Kingdom
Stem cell researchers of the United Kingdom “fertilised (the) first animal and then human eggs outside the body; a discovery that led to the creation of embryos outside the body and the subsequent birth of the first ‘test-tube baby’ (in vitro fertilisation) in 1978.” (www.mrc-centre.cam.ac.uk)

A British researcher, Sir John Gurdon, opened the door for animal cloning with the reprogramming of frog egg nucleus. He is co-winner of Shinya Yamanaka of Nobel Prize in Medicine in 2012 for their stem cell research.

The UK had pioneered in setting up a stem cell bank. “Set up in 2002 and partly funded by the MRC, the bank reduces the requirement for surplus embryos for the development of stem cell lines by individual research groups” (Internet. March 10,2014).
Researchers will go into guided differentiation into desired adult cells like muscles of the heart.

The potential of stem cells in screening drugs will be looked into. This may reduce the need to go through animal testing.
The Research Councils and Technology Strategy Board have agreed to develop regenerative medicine.

NORTH AMERICA

Canada
In 1963, Canadian scientists James Till and Ernest McCulloch identified and named stem cells. Since then Canadians have been at the forefront of scientific research, according to CBC digital archives (Internet March 10,2014).

Dr. Andras Nagy and his colleagues at Toronto’s Mount Sinai Hospital developed a method of turning skin cell into stem cells.” The new reprogramming method replaces a process that until now was done using viruses and carried the risk of damaging cell DNA and causing cancer.”

Stem cell DNA are inserted into a skin cell and ”removed after the skin cell transforms into a stem cell.” The produced stem cells are safer; the use of embryonic stem cells is not needed. This was announced in 2009 (Internet. March 10, 2014)

United States

“US President Barack Obama has reversed some barriers to human embryonic stem cell research,” in March 2009. This reversed the ban by Pres. Bill Clinton in 1995 owing to the ethical controversy over the use of human embryonic stem cells, according to the editorial of the Nature Cell Biology in 2010. “On August 23, 2012, in a decision favorable to proponents of embryonic stem cell research, the U.S. Court of Appeals for the D.C. Circuit… (dismissed) a lawsuit that challenged the Obama administration’s expansion of federal funding for embryonic stem cell research” (Internet, March 10,2014).”…Much remains to be done to ensure that stem cell research flourishes in the US in the coming decades,” the editorial said.

With the advent of the use of induced pluripotent stem cells research in stem cell therapy has advanced. However, since this therapy is considered to fall under drugs by the Food and Drug Administration of the USA, it will take long before this therapy becomes available to US consumers.

stemcellresearch-central-americaCENTRAL AMERICA

Panama
The Stem Cell Institute “arose from the unmet need to provide stem cell therapies that have been shown by others to meet the bar of safety in Phase I trials, but are not yet widely available because efficacy has not been proven.” It was founded by Neil Riordan, Ph.D. who comes from an American biotechnology company. Since 2006 the Institute has treated over 1800 patients. Dr. Riordan is the inventor of a nutritional supplement for use in stem cell therapy – Stem-Kine. It increases the population of stem cells and endothelium progenitor cells (EPC) in the bone marrow. EPCs circulate the stem cells to home to damaged part of the body and promotes healing.

“We collaborate with doctors and scientists at major universities in the US, Canada, and Costa Rica; including the University of California, San Diego, University of Utah, University of Western Ontario, University of Florida, University of Massachusetts, and the University of Costa Rica. We are in the planning stages of performing clinical trials in collaboration with New York University and the University of Miami” according to the Stem Cell Institute (Internet. March 10,2014).

SOUTH AMERICA

Brazil
The Brazilian government has set up a national Review Board system to increase research activity and the prospect of treating chronic and degenerative diseases using cell therapy since 2010.

The Science and Technology Department of the Ministry of Health in collaboration with the National Research Council have funded more than 100 projects since 2005. Several groups constitute the Brazilian Cell Therapy Network to promote interaction among research laboratories. “Around US$50 million have been disbursed to the Network by the government between 2005 and 2010” (Internet. March 10,2014).

Global Stem Cell News

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Study finds barriers to stem cell transplant use among multiple myeloma patients from minority groups
December 13, 2017 | rss feed
A study by researchers at Mayo Clinic's campus in Jacksonville, Florida has found that barriers to patients receiving stem cell therapy as part of their treatment for multiple myeloma include income, education, insurance status and access to care at... [read more]
Study reveals impact of diabetes during pregnancy on baby’s heart
December 13, 2017 | rss feed
A new study conducted at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA discovered how increased glucose levels caused either by diabetes or other factors keep heart cells from maturing... [read more]
Human Pluripotent Stem Cells to Produce Cell-based Cancer Immunotherapy
December 13, 2017 | rss feed
Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These... [read more]
Concise review: The Cellular Conspiracy of ALS
December 13, 2017 | rss feed
Amyotrophic lateral sclerosis (ALS) is incurable and devastating. A dearth of therapies has galvanized experimental focus onto the cellular and molecular mechanisms that both initiate and subsequently drive motor neuron (MN) degeneration. A traditional view of ALS pathogenesis posits that... [read more]
The gp130 Cytokine IL-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients
December 13, 2017 | rss feed
During bone marrow transplantation (BMT), hematopoietic stem and progenitor cells (HSPCs) respond to signals from the hematopoietic microenvironment (HM) by coordinately activating molecular pathways through Rho GTPases, including Rac. We have previously shown that deletion of Vav1, a... [read more]
Adaptation of the Bone Marrow Stroma in Hematopoietic Malignancies – Current Concepts and Models
December 13, 2017 | rss feed
The bone marrow stroma maintains hematopoiesis and coordinately regulates regenerative responses through dynamic interactions with hematopoietic stem and progenitor cells. Recent studies indicate that stromal components in the bone marrow of leukemia patients undergo a process of successive... [read more]
Researchers discover how high glucose levels in pregnancy affect baby’s heart
December 13, 2017 | rss feed
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered how high glucose levels -- whether caused by diabetes or other factors -- keep heart cells from maturing... [read more]
Delta-like 4 Activates Notch3 to Regulate Self-Renewal in Skeletal Muscle Stem Cells
December 12, 2017 | rss feed
Notch signalling is essential to maintain skeletal muscle stem cells in quiescence. The precise roles of the different Notch receptors are, however, incompletely defined. Here we demonstrate a role for Notch3 in the self-renewal of muscle stem cells. We found that Notch3 is active in quiescent... [read more]
Intercellular Transfer of Microvesicles from Young Mesenchymal Stromal Cells Rejuvenates Aged Murine Hematopoietic Stem Cells
December 12, 2017 | rss feed
Donor age is one of the major concerns in Bone Marrow Transplantation, as the aged hematopoietic stem cells (HSCs) fail to engraft efficiently. Here, using murine system we show that a brief interaction of aged HSCs with young mesenchymal stromal cells (MSCs) rejuvenates them and restores their... [read more]
A novel approach to single cell RNA-seq analysis facilitates in silico gene reporting of human pluripotent stem cell-derived retinal cell types
December 12, 2017 | rss feed
Cell type-specific investigations commonly employ gene reporters or single-cell (sc) analytical techniques. However, reporter line development is arduous and generally limited to a single gene of interest, while scRNA-seq frequently yields equivocal results that preclude definitive cell... [read more]
Genentech researchers uncover epigenetic regulator of pancreatic cancer cells
December 12, 2017 | rss feed
Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells'... [read more]
Study provides new insights into mechanism of tumor survival in glioblastoma
December 12, 2017 | rss feed
A Northwestern Medicine study, published in the journal Cancer Cell, has provided new insights into a mechanism of tumor survival in glioblastoma and demonstrated that inhibiting the process could enhance the effects of radiation... [read more]
Scientists develop software that predicts leukemia-specific immune targets
December 11, 2017 | rss feed
University of North Carolina Lineberger Comprehensive Cancer Center scientists have developed a software program that can accurately predict which tumor-specific markers will show up on the surface of leukemia cells in patients who have received stem... [read more]
Pairing immunotherapy drug with chemotherapy proves beneficial for relapsed acute myeloid leukemia
December 11, 2017 | rss feed
University of North Carolina Lineberger Comprehensive Cancer Center researchers report that pairing an immunotherapy drug with chemotherapy proved beneficial for some patients with acute myeloid leukemia whose disease did not respond to standard... [read more]
St. Jude gene therapy offers hope for infants with ‘bubble boy’ disease
December 11, 2017 | rss feed
Early evidence suggests that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency... [read more]
St. Jude gene therapy offers hope for infants with ‘bubble boy’ disease
December 11, 2017 | rss feed
Early evidence suggests that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency... [read more]
Differences in the Activity of Endogenous BMP Signalling Impact on the Ability of Induced Pluripotent Stem Cells to Differentiate to Corneal Epithelial Like Cells
December 11, 2017 | rss feed
Cornea is a clear outermost layer of the eye which enables transmission of light onto the retina. The transparent corneal epithelium is regenerated by limbal stem cells (LSCs), whose loss/dysfunction results in limbal stem cell deficiency (LSCD). Ex vivo expansion of autologous LSCs obtained from... [read more]
Alpha-Klotho Enrichment in Induced Pluripotent Stem Cell Secretome Contributes to Antioxidative Protection in Acute Lung Injury
December 11, 2017 | rss feed
Induced pluripotent stem cells (iPSCs) has been reported to alleviate organ injury, although the mechanisms of action remain unclear and administration of intact cells faces many limitations. We hypothesized that cell-free conditioned media (CM) containing the secretome of iPSCs possess... [read more]
Cell Therapy for Critical Limb Ischemia: An Integrated Review of Pre-clinical and Clinical Studies
December 11, 2017 | rss feed
Critical limb ischemia (CLI), the most severe form of peripheral artery disease, is characterized by pain at rest and non-healing ulcers in the lower extremities. For patients with CLI, where the extent of atherosclerotic artery occlusion is too severe for surgical bypass or percutaneous... [read more]
CAR T cell therapy shows long-lasting remissions in non-Hodgkin’s lymphoma patients
December 11, 2017 | rss feed
In a pair of clinical trials stretching from Philadelphia to Tokyo, the chimeric antigen receptor (CAR) T cell therapy Kymriah (formerly known as CTL019) demonstrated long-lasting remissions in non-Hodgkin's lymphoma (NHL)... [read more]
New genetic model identified for predicting outcomes in patients with primary myelofibrosis
December 11, 2017 | rss feed
A group of investigators from Mayo Clinic and multiple academic research centers in Italy have identified a genetic model for predicting outcomes in patients with primary myelofibrosis who are 70 years or younger and candidates for stem cell... [read more]
Drug improves disease-free, overall survival after hematopoietic stem cell transplants
December 11, 2017 | rss feed
Results from a phase 2 clinical trial, presented by Seattle Children's Research Institute at the 59th American Society of Hematology Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life-threatening severe acute... [read more]
Two immunotherapy approaches for multiple myeloma show hope
December 11, 2017 | rss feed
Researchers from the University of Pennsylvania's Abramson Cancer Center have developed two experimental immunotherapy methods that include one chimeric antigen receptor (CAR) T cell therapy for the treatment of multiple myeloma patients who were not... [read more]
3D mini brains put researchers on a fast track to repair the nervous system
December 8, 2017 | rss feed
The Houston Methodist Research Institute is making mini brains from human stem cells that put researchers on a fast track to repair the nervous system after injury or disease of the brain and spinal... [read more]
Optogenetics research sheds new light on social-spatial learning
December 8, 2017 | rss feed
Ilana Witten didn't set out to study spatial learning. She thought she was investigating how mice socialize--but she discovered that in mouse brains, the social and the spatial are inextricably... [read more]
High ADAR1 enzyme levels correlate with reduced survival rates in multiple myeloma
December 6, 2017 | rss feed
Multiple myeloma is the second most common blood cancer in the United States. Thirty to 50 percent of multiple myeloma patients have extra copies of the gene that encodes the enzyme... [read more]
Scientists develop multi-step method to harvest amniotic fluid
December 6, 2017 | rss feed
Amniotic fluid, the protective liquid surrounding an unborn baby, is discarded as medical waste during cesarean section... [read more]
Concise Review: The Use of Stem Cells for Understanding and Treating Huntington’s Disease
December 6, 2017 | rss feed
Two decades ago, researchers identified that a CAG expansion mutation in the huntingtin (HTT) gene was involved in the pathogenesis of Huntington's disease (HD). However, since the identification of the HTT gene, there has been no advance in the development of therapeutic strategies to prevent or... [read more]
New mass-production platform overcomes barriers to bioengineering human liver tissues
December 6, 2017 | rss feed
Researchers report creating a biologically accurate mass-production platform that overcomes major barriers to bioengineering human liver tissues suitable for therapeutic transplant into... [read more]
Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis
December 5, 2017 | rss feed
There's a continued drive towards making in vitro assays ever more translational towards in vivo models and ultimately the clinic. This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the... [read more]
Long Noncoding RNA-1604 Orchestrates Neural Differentiation Through the miR-200c/ZEB Axis
December 5, 2017 | rss feed
Clarifying the regulatory mechanisms of embryonic stem cell (ESC) neural differentiation is helpful not only for understanding neural development, but also for obtaining high-quality neural progenitor cells required by stem cell therapy of neurodegenerative diseases. Here, we found that long... [read more]
Cover Image
December 4, 2017 | rss feed
Cover Art: Section of a human kidney organoid derived from pluripotent stem cells, stained with nephron segment markers. Podocytes, the specialized filtering cells of the kidney, express nephrin (red) and form tight clusters. These connect to tubular... [read more]
UC San Diego researchers receive nearly $8 million grant for new stem cell-based AML treatments
December 4, 2017 | rss feed
The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine unanimously approved yesterday two grants worth a total of almost $8 million to University of California San Diego School of Medicine researchers... [read more]
Research suggests general mechanism by which dietary fats affect cellular physiology
December 1, 2017 | rss feed
You are what you eat when it comes to fat, report scientists from McGovern Medical School at The University of Texas Health Science Center at Houston in the journal Science... [read more]
Researchers identify vulnerability for glioblastoma subtypes
December 1, 2017 | rss feed
Glioblastoma, the most common and aggressive form of brain cancer, typically fails to respond to treatment or rapidly becomes drug... [read more]
UT Southwestern researchers develop improved gene-editing technique to correct DMD mutations
November 30, 2017 | rss feed
Regenerative medicine researchers at UT Southwestern Medical Center developed an improved and simplified gene-editing technique using CRISPR/Cas9 tools to correct a common mutation that causes Duchenne muscular... [read more]
Penn researchers reveal new approach to restart replication in cardiomyocytes after heart attack
November 30, 2017 | rss feed
In mammals, including humans, the cells that contract the heart muscle and enable it to beat do not regenerate after... [read more]
Cancer stem cells destroyed by drug-filled nanoparticles
November 29, 2017 | rss feed
Scientists show how drug-laden nanoparticles can find and destroy cancer stem cells that hide in tissue for years before causing the cancer to... [read more]
New pluripotent stem cell technology provides insights into neuropsychiatric disorders
November 29, 2017 | rss feed
Studying the genetic code allows researchers to know whether some patients with neuropsychiatric disorders either have extra copies of the CHRNA7 gene or are missing copies. However, little was known about the functional consequences of this genetic... [read more]
Low osteogenic yield in human pluripotent stem cells associates with differential neural crest promoter methylation
November 29, 2017 | rss feed
Human pluripotent stem cell-derived osteoblasts possess great potential for utilization in bone disorder elucidation and repair; yet, while the general ability of human pluripotent stem cells to differentiate into osteoblasts and lay down bone-specific matrix has been shown, previous studies lack... [read more]
Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of Müller Glia-Derived Progenitor Cells in the Avian Retina
November 28, 2017 | rss feed
In the retina, Müller glia have the potential to become progenitor cells with the ability to proliferate and regenerate neurons. However, the ability of Müller glia-derived progenitor cells (MGPCs) to proliferate and produce neurons is limited in higher vertebrates. Using the chick model system,... [read more]
Selectively deleting stem cell factor promotes recovery after TBI in mice
November 18, 2017 | rss feed
UT Southwestern molecular biologists today report the unexpected finding that selectively deleting a stem cell transcription factor in adult mice promotes recovery after traumatic brain injury... [read more]
Researchers uncover mechanism that contributes to patterns of degeneration in AD
November 17, 2017 | rss feed
Alzheimer's disease (AD) is known to cause memory loss and cognitive decline, but other functions of the brain can remain... [read more]
Old World monkeys could hold key to stop progression of rheumatoid arthritis
November 17, 2017 | rss feed
In the quest for a new and more effective treatment for rheumatoid arthritis, researchers from the Keck School of Medicine of USC looked to a primate that mostly roams the land in Asia, the Middle East and... [read more]
Drug used to prevent and treat malaria may also be effective for Zika virus
November 17, 2017 | rss feed
A new collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute and UC San Diego School of Medicine has found that a medication used to prevent and treat malaria may also be effective for Zika... [read more]
Type 1 diabetes: Could modified blood stem cells lead to a cure?
November 17, 2017 | rss feed
Researchers found that modifying blood stem cells to raise their levels of a T cell-blocking protein called PD-L1 reversed hyperglycemia in diabetic... [read more]
Brain astrocytes could play key role in pathogenesis of Alzheimer’s disease
November 17, 2017 | rss feed
Astrocytes, the supporting cells of the brain, could play a significant role in the pathogenesis of Alzheimer's disease (AD), according to a new study from the University of Eastern Finland. This is the first time researchers discovered a direct... [read more]
Breakthrough research brings new procedure closer to helping patients with blood cancer
November 17, 2017 | rss feed
A new procedure that can prevent the potentially lethal side effects of stem cell transplants is a step closer to helping more patients with blood cancers after a breakthrough in understanding of the key mechanism that makes it... [read more]
Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury
November 17, 2017 | rss feed
Production of an appropriate number of distinct cell types in precise locations during embryonic development is critical for proper tissue function. Homeostatic renewal or repair of damaged tissues in adults also requires cell expansion and transdifferentiation to replenish lost cells. However, the... [read more]
Stem cell treatment allows paraplegic rats to walk and regain sensory perception
November 17, 2017 | rss feed
Engineered tissue containing human stem cells has allowed paraplegic rats to walk independently and regain sensory... [read more]
Long Noncoding RNA RP11-380D23.2 Drives Distal-Proximal Patterning of the Lung by Regulating PITX2 Expression
November 16, 2017 | rss feed
Early lung development is a tightly orchestrated process encompassing (a) formation of definitive endoderm, (b) anteriorization of definitive endoderm, followed by (c) specification and maturation of both proximal and distal lung precursors. Several reports detailing the interaction of genes and... [read more]
Stem cell therapy fails to improve walking ability in people with PAD
November 16, 2017 | rss feed
A stem cell therapy did not improve walking ability in people with peripheral artery disease, although exercise did lead to significant improvements, according to the results of a new Northwestern Medicine clinical... [read more]
Scientists find key that allows neural differentiation of microRNA-deficient pluripotent stem cells
November 15, 2017 | rss feed
The more than 200 different types of human cells have the same DNA but express different ensembles of genes. Each cell type was derived from embryonic stem cells, which are called pluripotent stem cells because they can differentiate to all those... [read more]
Notch1 and Notch2 Coordinately Regulate Stem Cell Function in the Quiescent and Activated States of Muscle Satellite Cells
November 15, 2017 | rss feed
Satellite cells, the muscle tissue stem cells, express three Notch receptors (Notch1–3). The function of Notch1 and Notch2 in satellite cells has to date not been fully evaluated. We investigated the role of Notch1 and Notch2 in myogenic progression in adult skeletal muscle using... [read more]
Notch1 and Notch2 Coordinately Regulate Stem Cell Function in the Quiescent and Activated States of Muscle Satellite Cells
November 15, 2017 | rss feed
Satellite cells, the muscle tissue stem cells, express three Notch receptors (Notch1–3). The function of Notch1 and Notch2 in satellite cells has to date not been fully evaluated. We investigated the role of Notch1 and Notch2 in myogenic progression in adult skeletal muscle using... [read more]
Single cell resolution of human hemato-endothelial cells defines transcriptional signatures of hemogenic endothelium
November 15, 2017 | rss feed
Endothelial-to-hematopoietic transition (EHT) is an important stage in definitive hematopoietic development. However, the genetic mechanisms underlying human EHT remains poorly characterized. We performed single cell RNA-seq using 55 hemogenic endothelial cells (HE:... [read more]
Single cell resolution of human hemato-endothelial cells defines transcriptional signatures of hemogenic endothelium
November 15, 2017 | rss feed
Endothelial-to-hematopoietic transition (EHT) is an important stage in definitive hematopoietic development. However, the genetic mechanisms underlying human EHT remains poorly characterized. We performed single cell RNA-seq using 55 hemogenic endothelial cells (HE:... [read more]
HAX-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation
November 15, 2017 | rss feed
Endothelial precursor cells (EPCs) are involved in vasculogenesis of various physiological and pathological processes. The proliferation and survival mechanism of EPCs needs to be explored further for the purpose of developing an effective glioma treatment. Hematopoietic-substrate-1 associated... [read more]
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation
November 15, 2017 | rss feed
Endothelial precursor cells (EPCs) are involved in vasculogenesis of various physiological and pathological processes. The proliferation and survival mechanism of EPCs needs to be explored further for the purpose of developing an effective glioma treatment. Hematopoietic substrate-1-associated... [read more]
Study provides new insights into basis for responsiveness of testicular cancer to chemotherapy
November 15, 2017 | rss feed
Cornell researchers have taken a major step toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it... [read more]
Monoclonal antibody effectively blocks development of graft-versus-host disease, research shows
November 14, 2017 | rss feed
Newly published research provides preclinical proof-of-concept for the ability of PRO 140, a humanized anti-CCR5 monoclonal antibody under development by CytoDyn Inc., to effectively block the development of graft-versus-host disease (GvHD), a... [read more]
New drug shows promise in mouse model of autism disorder
November 14, 2017 | rss feed
Scientists have performed a successful test of a possible new drug in a mouse model of an autism disorder. The candidate drug, called NitroSynapsin, largely corrected electrical, behavioral and brain abnormalities in the... [read more]
Researchers find efficient way to produce neurons from pluripotent stem cells
November 13, 2017 | rss feed
Since their discovery in 2006, induced pluripotent stem cells are a glimmer of hope for many diseases. But further research of the complex regulation of pluripotent stem cell identity revealed unexpected... [read more]
Advances in genetic and stem cell techniques help identify therapeutic targets for neurological disorders
November 13, 2017 | rss feed
Research released today highlights advances in the use of CRISPR-Cas9 and human induced pluripotent stem cell technologies to identify novel therapeutic targets for neurological disorders such as schizophrenia and... [read more]
Advanced Cell Culture Models for Diamond Blackfan Anemia and other Erythroid Disorders
November 10, 2017 | rss feed
In vitro surrogate models of human erythropoiesis made many contributions to our understanding of the extrinsic and intrinsic regulation of this process in vivo and how they are altered in erythroid disorders. In the past, variability among the levels of hemoglobin F produced by adult erythroblasts... [read more]
Concise Review: Advanced Cell Culture Models for Diamond Blackfan Anemia and Other Erythroid Disorders
November 10, 2017 | rss feed
In vitro surrogate models of human erythropoiesis made many contributions to our understanding of the extrinsic and intrinsic regulation of this process in vivo and how they are altered in erythroid disorders. In the past, variability among the levels of hemoglobin F produced by adult erythroblasts... [read more]
Advanced Cell Culture Models for Diamond Blackfan Anemia and other Erythroid Disorders
November 10, 2017 | rss feed
In vitro surrogate models of human erythropoiesis made many contributions to our understanding of the extrinsic and intrinsic regulation of this process in vivo and how they are altered in erythroid disorders. In the past, variability among the levels of hemoglobin F produced by adult erythroblasts... [read more]
Advanced Cell Culture Models for Diamond Blackfan Anemia and other Erythroid Disorders
November 10, 2017 | rss feed
In vitro surrogate models of human erythropoiesis made many contributions to our understanding of the extrinsic and intrinsic regulation of this process in vivo and how they are altered in erythroid disorders. In the past, variability among the levels of hemoglobin F produced by adult erythroblasts... [read more]
Advanced Cell Culture Models for Diamond Blackfan Anemia and other Erythroid Disorders
November 10, 2017 | rss feed
In vitro surrogate models of human erythropoiesis made many contributions to our understanding of the extrinsic and intrinsic regulation of this process in vivo and how they are altered in erythroid disorders. In the past, variability among the levels of hemoglobin F produced by adult erythroblasts... [read more]
3D cultured spheroids could drive precision treatment for ovarian cancer
November 9, 2017 | rss feed
Honeycomb-like arrays of tiny, lab-grown cancers could one day help doctors zero in on individualized treatments for ovarian cancer, an unpredictable disease that kills more than 14,000 women each year in the United States... [read more]
Eukaryotic Initiation Factor 5A2 Contributes to the Maintenance of CD133(+) Hepatocellular Carcinoma Cells via the c-Myc/microRNA-29b Axis
November 9, 2017 | rss feed
Cancer stem cells (CSCs)/cancer-initiating cells (CICs) are suggested responsible for driving cancer resistance to conventional therapies and for cancer recurrence and/or metastasis. CD133 is served as a key biomarker to identify and characterize this subpopulation of cells in hepatocellular... [read more]
How gene therapy saved a little boy’s life
November 8, 2017 | rss feed
Epidermolysis bullosa gives rise to painful blisters and chronic wounds. Doctors were sure that one little boy was going to lose his life — but he... [read more]
IUD use linked to dramatic decrease in incidence of cervical cancer
November 8, 2017 | rss feed
Considered a safe and highly effective contraception method, intrauterine devices (IUDs) may also be quietly offering protection against the third-most common cancer in women... [read more]
Stem cells could help improve blood circulation in diabetic patients with peripheral artery disease
November 7, 2017 | rss feed
Stem cells taken from muscle tissue could promote better blood flow in patients with diabetes who develop peripheral artery disease, a painful complication that can require surgery or lead to... [read more]
Study shows promise and potential risk in reversing hearing loss using inner ear stem cells
November 7, 2017 | rss feed
Want to restore hearing by injecting stem cells into the inner ear? Well, that can be a double-edged... [read more]
Production of nitric oxide crucial for stem cell mobilization and differentiation
November 2, 2017 | rss feed
Nathan Bryan, PH.D., one of the nation's leading experts on critically important role of nitric oxide in health and disease prevention, told attendees of the Pacific Regenerative Medicine 2017 Conference this morning that, "Stem cells are the future... [read more]
FDA issues warning letters to companies illegally selling products that claim to cure cancer
November 2, 2017 | rss feed
As part of the U.S. Food and Drug Administration's ongoing efforts to protect consumers from health fraud, the agency today issued warning letters to four companies illegally selling products online that claim to prevent, diagnose, treat, or cure... [read more]
FDA warning on miracle marijuana cures for cancer
November 2, 2017 | rss feed
Yesterday, 1st November 2017, the U.S. Food and Drug Administration, FDA, released a statement warning the general public against fraudulent claims regarding marijuana based cancer cures. The FDA has also issued warnings in writing to four companies... [read more]
Livecyte™ Cell Imaging and Analysis system adopted by the Translational Research Institute, Australia
November 1, 2017 | rss feed
The Translational Research Institute (TRI), Brisbane has become the first centre in Australia and the Asia Pacific region to adopt the Livecyte™ Cell Imaging and Analysis... [read more]
Conference to focus on preventing and reversing consequences of sickle cell disease
November 1, 2017 | rss feed
Leading experts in the field of sickle cell disease (SCD) research will convene in Washington, D.C., for the Physiological and Pathophysiological Consequences of Sickle Cell Disease conference (November 6–8). The conference, organized by the American... [read more]
Cleveland Clinic researcher awarded $2.6 million grant to create innovative models of colorectal cancer
October 31, 2017 | rss feed
Cleveland Clinic researcher Emina Huang, M.D., a colorectal surgeon in the Digestive Disease and Surgery Institute and a staff member in the Lerner Research Institute's Department of Stem Cell Biology and Regenerative Medicine, has been awarded a... [read more]
Stem cells do not participate directly in cartilage regeneration but serve to ‘animate’ the process
October 31, 2017 | rss feed
Stem cell therapy has great potential for curing cartilage damage. However, it has remained unclear whether stem cells are responsible for regeneration or whether they trigger the... [read more]
Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling
October 31, 2017 | rss feed
Background: The ability to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes (CMs) makes them an attractive source for repairing injured myocardium, disease modeling, and drug testing. Although current differentiation protocols yield hPSC-CMs to >90% efficiency, hPSC-CMs... [read more]
Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling
October 31, 2017 | rss feed
The ability to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes (CMs) makes them an attractive source for repairing injured myocardium, disease modeling, and drug testing. Although current differentiation protocols yield hPSC-CMs to >90% efficiency, hPSC-CMs exhibit... [read more]
Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration
October 31, 2017 | rss feed
Hematopoietic regeneration following chemotherapy may be distinct from regeneration following radiation. While we have shown that epidermal growth factor (EGF) accelerates regeneration following radiation, its role following chemotherapy is currently unknown. We sought to identify EGF as a... [read more]
Cover Image
October 28, 2017 | rss feed
Cover Art: iPSC can be generated from patients with age-related macular degeneration with the Y402H single nucleotide polymorphism in complement factor H. When differentiated to retinal pigmented epithelial cells, molecular, structural, and... [read more]
Inflammation-Stimulated Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Inflammation
October 27, 2017 | rss feed
Extracellular vesicles (EVs) secreted by mesenchymal stromal cells (MSCs) have been proposed to be a key mechanistic link in the therapeutic efficacy of cells in response to cellular injuries through paracrine effects. We hypothesize that inflammatory stimulation of MSCs results in the release of... [read more]
Brief Report: Three-Dimensional Culture Reduces Cell Size by Increasing Vesicle Excretion
October 27, 2017 | rss feed
Our previous study has shown that three-dimensional (3D) culture decreases mesenchymal stem cell (MSC) size, leading to enhanced trafficking ability and reduced lung vascular obstructions. However, the underlying mechanisms are unclear. In this study, we proposed that 3D culture reduces MSC size by... [read more]
Researchers find link between disrupted energy production and late-onset Alzheimer’s disease
October 27, 2017 | rss feed
A team of investigators from McLean Hospital and Harvard Medical School, led by Kai C. Sonntag, MD, PhD, and Bruce M. Cohen, MD, PhD, has found a connection between disrupted energy production and the development of late-onset Alzheimer's disease... [read more]
‘Precision Medicine’ may not always be so precise when applied to diverse populations, study says
October 27, 2017 | rss feed
Precision Medicine in oncology, where genetic testing is used to determine the best drugs to treat cancer patients, is not always so precise when applied to some of the world's more diverse populations, according to a study led by the Translational... [read more]
AMSBIO launches new service for synthesis of custom-designed synthetic mRNAs
October 26, 2017 | rss feed
AMSBIO announces the launch of a new service for synthesis of custom-designed, highly modified mRNAs prepared by an advantageous in vitro transcription... [read more]
JGU researchers develop new technique to facilitate differentiation of stem cells into neurons
October 26, 2017 | rss feed
Very little is still known about how neurons can be generated from stem cells. Researchers at the University Medical Center of Johannes Gutenberg University Mainz have now developed a promising technique that will facilitate the differentiation of... [read more]
VICC selected to administer FDA-approved CAR T therapy for treatment of lymphoma patients
October 26, 2017 | rss feed
Vanderbilt-Ingram Cancer Center has been selected as one of the few authorized treatment centers in the United States approved to administer the first FDA- approved chimeric antigen receptor T cell (CAR T) therapy for treatment of adult patients with... [read more]