From 1908 when their existence was first hypothesized and the name “Stem Cell” was coined, it was then 70 years before definitive proof of their existence was shown in 1978. In the decades since then, research employing Stem Cells as treatments and therapies has exploded off the charts with research being conducted on nearly all the continents. The staff at StemCell101.com is dedicated to combing the internet, trade journals, and medical publications to bring consumers the latest information and news about this exciting and promising field.

stemcell-research 

The following are just some examples of the Worldwide Research Effort:

AFRICA

South Africa
In March 2012 scientists at South Africa’s Council for Scientific and Industrial Research (CSIR) set up a facility for biomedical stem cell technology. Its gene expression and biophysics group generated the first induced pluripotent stem cells (iPSCs) in Africa, the CSIR announced.

ASIA

China
China holds unrestrictive policies in regard to embryonic stem cell research – one of the most unrestrictive in the world. With this atmosphere Chinese scientists who have been educated and been trained in the West have flocked back to set up stem cell research laboratories in their home country. Stem cell researchers in the West attest to the fact that stem cell research facilities and researchers in China are already world class.

India
In Bangalore, India, the Institute for Stem Cell Biology and Regenerative Medicine (inStem) has state-of-the-art research facilities. Research at inStem includes stem cell biology, looking into mechanism that control differentiation and renewal, and impact of stem cells on recovery from stroke. Also in India, the Chaitanya Stem Cell Centre gives information on neurology, kidney, liver and many untreatable diseases. It also pushes regenerative medicine..

Japan
The following report is derived from the editorial. “New horizon in stem cell research,” of The Japan Times, February 3,2014 issue. Dr. Haruko Obokata and her team have found that body cells taken from mice can be reprogrammed into stem cells by exposing them to low-PH acid liquids. This new way of reprogramming adult cells into pluripotent cells (embryonic stem cells) is called “stimulus-triggered acquisition of pluripotency” or STAP. The STAP method is easier than that used by Dr. Shinya Yamanaka of Kyoto University, co-recipient with Sir John Gurdon of the Nobel Prize in Physiology or Medicine in 2012. In 2006 Yamanaka produced embryonic stem cells out of mouse skin by introducing four genes as growth factors. The cells are called induced pluripotent stem cells (iPSC). Yamanaka and his team did the same on human skin cells in 2007. STAP cells can form placenta which iPSC cannot do. “It is hoped that more efforts will be made so that the discovery will lead to the advancement of regenerative medicine.”

South Korea
The Stem Cell Research Center (SCRC) is a government-funded organization that supports stem cell research.The SCRC acts is a funding agency with 52 projects throughout South Korea. A national network, the Korean Society for Stem Cell Research, has been set up to facilitate stem cell research. The Stem Cell Research Center is the biggest stem cell center supported by Ministry of Science and Technology. Several other centers are supported by ministries like the Ministry of Health and Welfare. Several non-government organizations support stem cell research.

stemcellresearch-australiaAUSTRALIA

Some stem cell research trials being conducted in Australia include…..

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  • Condition: Graft Versus Host Disease. Mesenchymal Stromal Cells for Acute Graft Versus Host Disease. The trial plans to enrol 66 patients by December 2015 and to be completed by December 2016.
  • Condition: Osteoarthritis. HiQCell Joint Registry in Patients with Osteoarthritis Following the HiQCell Procedure. The first patients underwent this procedure in July 2012.
  • Condition: Brain tumours. Gene Therapy and Chemotherapy for the Treatment of Childhood Brain Tumours. The trial commenced in July 2012.
  • Condition: Bone repair. Cranial Reconstruction Using Mesenchymal Stromal Cells and Resorbable Biomaterials. This trial is conducted at the Royal Perth Hospital in Western Australia from January 2013 to December 2015.
  • Condition: Leukaemia. Pilot Study of Partially Human Leucocyte Antigen-Mismatched Stem Cell Infusions after Chemotherapy for Acute Myeloid Leukaemia.
  • Condition: Osteoarthritis. The Osteoarthritis Stem Cell Advanced Research Study. This trial is conducted by the Rheumatology Department of the Royal North Shore Hospital St Leonards in New South Wales and Regeneus Pty Ltd. (Internet. March 10,2014)

[/lists]

EUROPE

Belgium
Belgian medical researchers succeeded in repairing bones using stem cells from fatty tissue.

The Saint Luc university clinic hospital in Brussels has a team that “has treated 11 patients, eight of them children, with fractures or bone defects that their bodies could not repair….” This was reported by the university on January 14, 2014. The breakthrough technique of Saint Luc’s centre for tissue and cellular therapy consists in removing a “sugar cube sized piece of fatty tissue from the patient, a less invasive process than pushing a needle into the pelvis and with a stem cell concentration they say is some 500 times higher.”

France
“The national assembly of France has voted to a lift a ban on embryonic stem cell research, which could pave the way for crucial scientific developments.” (France lifts its ban on embyonic stem cell reserch by Rebecca Taylor | Paris, France | LifeNews.com | 7/17/13)

I-Stem is the largest French laboratory for research and development devoted to embryonic origin obtained by reprogramming gene. It is a collaboration between Inserm – National Institute of Health and Medical Research – and AFM-Telethon – French Association against Myopathies.

Germany
Germany defines stem cell research as “the scientific study of embryonic, fetal, adult, as well as induced pluripotent stem cells of living organisms of all kinds. By definition, stem cells are cells that are not yet fully developed and therefore have the potential to differentiate into different cell types.” In the medical and biological fields findings in stem cell research are obtained and turned to benefit consumers. The ultimate goal is regenerating defective organs.

Spain
Spain has a comprehensive regulatory framework for stem cell research, consisting of laws and regulations on stem cell research. One partner in research is the Centre for Genomic Regulation. This is reported by “Regulation of stem cell research in Spain,” updated in August 2012.

United Kingdom
Stem cell researchers of the United Kingdom “fertilised (the) first animal and then human eggs outside the body; a discovery that led to the creation of embryos outside the body and the subsequent birth of the first ‘test-tube baby’ (in vitro fertilisation) in 1978.” (www.mrc-centre.cam.ac.uk)

A British researcher, Sir John Gurdon, opened the door for animal cloning with the reprogramming of frog egg nucleus. He is co-winner of Shinya Yamanaka of Nobel Prize in Medicine in 2012 for their stem cell research.

The UK had pioneered in setting up a stem cell bank. “Set up in 2002 and partly funded by the MRC, the bank reduces the requirement for surplus embryos for the development of stem cell lines by individual research groups” (Internet. March 10,2014).
Researchers will go into guided differentiation into desired adult cells like muscles of the heart.

The potential of stem cells in screening drugs will be looked into. This may reduce the need to go through animal testing.
The Research Councils and Technology Strategy Board have agreed to develop regenerative medicine.

NORTH AMERICA

Canada
In 1963, Canadian scientists James Till and Ernest McCulloch identified and named stem cells. Since then Canadians have been at the forefront of scientific research, according to CBC digital archives (Internet March 10,2014).

Dr. Andras Nagy and his colleagues at Toronto’s Mount Sinai Hospital developed a method of turning skin cell into stem cells.” The new reprogramming method replaces a process that until now was done using viruses and carried the risk of damaging cell DNA and causing cancer.”

Stem cell DNA are inserted into a skin cell and ”removed after the skin cell transforms into a stem cell.” The produced stem cells are safer; the use of embryonic stem cells is not needed. This was announced in 2009 (Internet. March 10, 2014)

United States

“US President Barack Obama has reversed some barriers to human embryonic stem cell research,” in March 2009. This reversed the ban by Pres. Bill Clinton in 1995 owing to the ethical controversy over the use of human embryonic stem cells, according to the editorial of the Nature Cell Biology in 2010. “On August 23, 2012, in a decision favorable to proponents of embryonic stem cell research, the U.S. Court of Appeals for the D.C. Circuit… (dismissed) a lawsuit that challenged the Obama administration’s expansion of federal funding for embryonic stem cell research” (Internet, March 10,2014).”…Much remains to be done to ensure that stem cell research flourishes in the US in the coming decades,” the editorial said.

With the advent of the use of induced pluripotent stem cells research in stem cell therapy has advanced. However, since this therapy is considered to fall under drugs by the Food and Drug Administration of the USA, it will take long before this therapy becomes available to US consumers.

stemcellresearch-central-americaCENTRAL AMERICA

Panama
The Stem Cell Institute “arose from the unmet need to provide stem cell therapies that have been shown by others to meet the bar of safety in Phase I trials, but are not yet widely available because efficacy has not been proven.” It was founded by Neil Riordan, Ph.D. who comes from an American biotechnology company. Since 2006 the Institute has treated over 1800 patients. Dr. Riordan is the inventor of a nutritional supplement for use in stem cell therapy – Stem-Kine. It increases the population of stem cells and endothelium progenitor cells (EPC) in the bone marrow. EPCs circulate the stem cells to home to damaged part of the body and promotes healing.

“We collaborate with doctors and scientists at major universities in the US, Canada, and Costa Rica; including the University of California, San Diego, University of Utah, University of Western Ontario, University of Florida, University of Massachusetts, and the University of Costa Rica. We are in the planning stages of performing clinical trials in collaboration with New York University and the University of Miami” according to the Stem Cell Institute (Internet. March 10,2014).

SOUTH AMERICA

Brazil
The Brazilian government has set up a national Review Board system to increase research activity and the prospect of treating chronic and degenerative diseases using cell therapy since 2010.

The Science and Technology Department of the Ministry of Health in collaboration with the National Research Council have funded more than 100 projects since 2005. Several groups constitute the Brazilian Cell Therapy Network to promote interaction among research laboratories. “Around US$50 million have been disbursed to the Network by the government between 2005 and 2010” (Internet. March 10,2014).

Global Stem Cell News

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Researchers target abnormal epigenetic mechanisms involved in childhood cancers
February 21, 2018 | rss feed
Several childhood cancer cell types show features of immature neural cells, and there is evidence suggesting that these tumors may arise from neural crest stem cells that underwent abnormal changes during embryonic... [read more]
Tiny ‘brains on chips’ reveal mechanisms underlying brain’s wrinkling process
February 21, 2018 | rss feed
Being born with a "tabula rasa" - a clean slate - in the case of the brain is something of a curse. Our brains are already wrinkled like walnuts by the time we are born. Babies born without these wrinkles - smooth brain syndrome - suffer from severe... [read more]
Lab-grown cerebellar cells may help explain how ASD develops at molecular level
February 19, 2018 | rss feed
Increasing evidence has linked autism spectrum disorder with dysfunction of the brain's cerebellum, but the details have been unclear. In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known... [read more]
Stem cell vaccine helps protect mice against numerous cancers, Study finds
February 16, 2018 | rss feed
Lab mice injected with inactivated induced pluripotent stem cells (iPSCs) displayed a significant immune response against lung, breast, and skin cancers. The vaccine also prevented relapses in animals with removed... [read more]
Therapeutic Neural Stem Cells Engineered During Different Stages of Reprogramming Reveal Varying Therapeutic Efficacies
February 16, 2018 | rss feed
Stem cells are emerging as promising treatment strategies for several brain disorders and pathologies including brain tumors. In this study, we explored the potential of creating induced pluripotent stem cell (iPSC) derived therapeutic NSCs (ipNSC) by using either unmodified or gene-modified... [read more]
An Indispensable Role of Androgen Receptor in Wnt Responsive Cells during Prostate Development, Maturation, and Regeneration
February 16, 2018 | rss feed
Androgen signaling is essential for prostate development, morphogenesis, and regeneration. Emerging evidence indicates that Wnt/β-catenin signaling also contributes to prostate development specifically through regulation of cell fate determination. Prostatic Axin2-expressing cells are able to... [read more]
Mesenchymal stem cells protect against hypoxia-ischemia brain damage by enhancing autophagy through BDNF/mTOR signaling pathway
February 16, 2018 | rss feed
Hypoxic-ischemic encephalopathy (HIE) is a serious disease for neonates. However, present therapeutic strategies are not effective enough for treating HIE. Previous study showed that mesenchymal stem cells (MSCs) can exert neuroprotective effects for brain damage, but its mechanism remains elusive.... [read more]
Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis
February 16, 2018 | rss feed
Endometriosis is ectopic growth of endometrial tissue traditionally thought to arise through retrograde menstruation. We aimed to determine if cells derived from endometriosis could enter vascular circulation and lead to hematogenous dissemination. Experimental endometriosis was established by... [read more]
Biomedical engineers grow living windpipe structures from self-assembled modules
February 15, 2018 | rss feed
Biomedical engineers at Case Western Reserve University are growing tracheas by coaxing cells to form three distinct tissue types after assembling them into a tube structure-;without relying on scaffolding strategies currently being investigated by... [read more]
New NK cell-based immunotherapy effective against several types of leukemia
February 15, 2018 | rss feed
Researchers at Karolinska Institutet in Sweden have explored NK cell-based immunotherapy on patients with treatment-resistant leukemia. The study, which is published in the scientific journal Clinical Cancer Research, shows that the new therapy is... [read more]
Scientists discover adult endothelial stem cells capable of generating fully functional blood vessels
February 15, 2018 | rss feed
The proper function of blood vessels is essential to life: blood vessels are responsible for transporting oxygen-rich red blood cells, nutrients, and immune cells throughout the body, to name just a few functions. Defects in blood vessels can... [read more]
Mice study raises hope to successfully treat Alzheimer’s disease
February 14, 2018 | rss feed
A team of researchers from the Cleveland Clinic Lerner Research Institute have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer's disease, thereby improving... [read more]
Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate
February 14, 2018 | rss feed
Aging severely limits myocardial repair and regeneration. Delineating the impact of age-associated factors such as short telomeres is critical to enhance the regenerative potential of cardiac progenitor cells (CPCs). We hypothesized that short telomeres activate p53 and induce autophagy to elicit... [read more]
Concise Review: Assessing the Genome Integrity of Human Induced Pluripotent Stem Cells: What Quality Control Metrics?
February 14, 2018 | rss feed
Human induced pluripotent stem cells (hiPSCs) have the potential to differentiate virtually into any cell type in unlimited quantities. Therefore, they are ideal for in vitro tissue modeling or to produce cells for clinical use. Importantly, and differently from immortalized and cancer cell lines,... [read more]
Replenishing a protein could improve healing properties of stem cell therapy after heart attack
February 13, 2018 | rss feed
Researchers may have found a way to reduce ongoing heart damage that occurs long after a severe heart attack by improving the longevity of stem cells injected into the... [read more]
Outcomes of Penetrating Keratoplasty following Autologous Cultivated Limbal Epithelial Stem Cell Transplantation
February 13, 2018 | rss feed
Purpose: To investigate the outcomes of penetrating keratoplasty (PKP) following autologous cultivated limbal epithelial stem cell transplantation (CLET). Methods: A prospective, single centre, interventional cohort study investigating patients with unilateral total limbal stem cell deficiency... [read more]
Intratumoral Delivery of Interferon γ-secreting MSCs Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo
February 12, 2018 | rss feed
Neuroblastoma, the most common extracranial solid tumor in childhood, remains a therapeutic challenge. However, one promising patient treatment strategy is the delivery of anti-tumor therapeutic agents via mesenchymal stromal cell (MSC) therapy. MSCs have been safely utilized to treat genetic bone... [read more]
Nfix Promotes Survival of Immature Hematopoietic Cells via Regulation of c-Mpl
February 12, 2018 | rss feed
Hematopoietic stem and progenitor cells (HSPC) are necessary for life-long blood production and replenishment of the hematopoietic system during stress. We recently reported that nuclear factor I/X (Nfix) promotes HSPC survival post-transplant. Here, we report that ectopic expression of Nfix in... [read more]
This protein fuels triple-negative breast cancer
February 10, 2018 | rss feed
Researchers report that they have identified a new stem cell pathway that drives the development of highly aggressive triple-negative breast... [read more]
This protein fuels triple-negative breast cancer
February 10, 2018 | rss feed
Researchers report that they have identified a new stem cell pathway that drives the development of highly aggressive triple-negative breast... [read more]
Chinese researchers report first clinical trial based on autologous lung stem cell transplantation
February 10, 2018 | rss feed
A research team from Tongji University in China have made a breakthrough in human lung regeneration technology. For the first time, researchers have regenerated patients' damaged lungs using autologous lung stem cell transplantation in a pilot... [read more]
Chinese researchers report first clinical trial based on autologous lung stem cell transplantation
February 10, 2018 | rss feed
A research team from Tongji University in China have made a breakthrough in human lung regeneration technology. For the first time, researchers have regenerated patients' damaged lungs using autologous lung stem cell transplantation in a pilot... [read more]
Study provides valuable insights to prevalence of burnout in neurosurgery residents
February 10, 2018 | rss feed
When it comes to workplace stress, even doctors aren't immune to its effects. For doctors training to become neurosurgeons, burnout is common, and certain workplace stressors -- like unrewarding mentor relationships, difficult coworkers and not... [read more]
Study provides valuable insights to prevalence of burnout in neurosurgery residents
February 10, 2018 | rss feed
When it comes to workplace stress, even doctors aren't immune to its effects. For doctors training to become neurosurgeons, burnout is common, and certain workplace stressors -- like unrewarding mentor relationships, difficult coworkers and not... [read more]
Scientists successfully produce functioning human kidney tissue
February 10, 2018 | rss feed
Scientists have successfully produced human kidney tissue within a living organism which is able to produce urine, a first for medical... [read more]
Scientists successfully produce functioning human kidney tissue
February 10, 2018 | rss feed
Scientists have successfully produced human kidney tissue within a living organism which is able to produce urine, a first for medical... [read more]
Using CRISPR To Produce Induced Pluripotent Stem Cells
February 9, 2018 | rss feed
An interview with Dr. Sheng Ding about using a modified version of the CRISPR-Cas9 system to produce induced pluripotent stem... [read more]
Using CRISPR To Produce Induced Pluripotent Stem Cells
February 9, 2018 | rss feed
An interview with Dr. Sheng Ding about using a modified version of the CRISPR-Cas9 system to produce induced pluripotent stem... [read more]
Scientists design new triple labeling technique to analyze stem cell division
February 9, 2018 | rss feed
A joint team of scientists from Russia and the United States designed a method for marking dividing stem cells with three different... [read more]
Scientists design new triple labeling technique to analyze stem cell division
February 9, 2018 | rss feed
A joint team of scientists from Russia and the United States designed a method for marking dividing stem cells with three different... [read more]
Human iPS cell-derived inner ear cells may improve hereditary hearing loss
February 9, 2018 | rss feed
A Japanese research group has successfully grafted human iPS cell-derived inner ear cells that express human-derived proteins into the inner ears of embryonic... [read more]
Human iPS cell-derived inner ear cells may improve hereditary hearing loss
February 9, 2018 | rss feed
A Japanese research group has successfully grafted human iPS cell-derived inner ear cells that express human-derived proteins into the inner ears of embryonic... [read more]
Study finds new stem cell pathway that allows triple-negative breast cancer to thrive
February 8, 2018 | rss feed
Cleveland Clinic researchers have published findings in Nature Communications on a new stem cell pathway that allows a highly aggressive form of breast cancer - triple-negative breast cancer - to... [read more]
Study finds new stem cell pathway that allows triple-negative breast cancer to thrive
February 8, 2018 | rss feed
Cleveland Clinic researchers have published findings in Nature Communications on a new stem cell pathway that allows a highly aggressive form of breast cancer - triple-negative breast cancer - to... [read more]
Researchers discover molecule that enhances cartilage regeneration and curbs inflammation
February 7, 2018 | rss feed
Will there come a time when a patient with arthritis can forgo joint replacement surgery in favor of a shot? Keck School of Medicine of USC scientist Denis Evseenko, MD, PhD, has reason to be... [read more]
Researchers discover molecule that enhances cartilage regeneration and curbs inflammation
February 7, 2018 | rss feed
Will there come a time when a patient with arthritis can forgo joint replacement surgery in favor of a shot? Keck School of Medicine of USC scientist Denis Evseenko, MD, PhD, has reason to be... [read more]
USC scientists uncover cellular mechanism responsible for ALS and frontotemporal dementia
February 7, 2018 | rss feed
Scientists have for the first time discovered a mechanism that limits the number of "cellular janitors" in the nervous system, leading to increased risk for two neurodegenerative diseases: amyotrophic lateral sclerosis and frontotemporal dementia,... [read more]
USC scientists uncover cellular mechanism responsible for ALS and frontotemporal dementia
February 7, 2018 | rss feed
Scientists have for the first time discovered a mechanism that limits the number of "cellular janitors" in the nervous system, leading to increased risk for two neurodegenerative diseases: amyotrophic lateral sclerosis and frontotemporal dementia,... [read more]
New CRISPR gene-editing technique can correct majority of mutations that cause DMD
February 7, 2018 | rss feed
Scientists have developed a CRISPR gene-editing technique that can potentially correct a majority of the 3,000 mutations that cause Duchenne muscular dystrophy (DMD) by making a single cut at strategic points along the patient's DNA, according to a... [read more]
New CRISPR gene-editing technique can correct majority of mutations that cause DMD
February 7, 2018 | rss feed
Scientists have developed a CRISPR gene-editing technique that can potentially correct a majority of the 3,000 mutations that cause Duchenne muscular dystrophy (DMD) by making a single cut at strategic points along the patient's DNA, according to a... [read more]
CHLA participates in clinical trial using stem cells to treat rare congenital heart defect
February 6, 2018 | rss feed
Children's Hospital Los Angeles is announcing participation in the first-ever clinical trial using stem cells from umbilical cord blood to delay or even prevent heart failure in children born with a rare congenital heart defect that leaves them with... [read more]
Researchers devise strategies to target glioma stem cells that could improve patient survival
February 6, 2018 | rss feed
Glioblastoma multiforme is the most common and aggressive primary brain tumor and has one of the worst survival rates of all... [read more]
Moffitt study identifies new drug target that may reduce GVHD risk
February 6, 2018 | rss feed
Stem cell transplants can cure patients with high-risk leukemia or lymphoma. Graft-versus-host disease is a potentially life-threatening side effect that occurs when the donor's immune cells attack the recipient's normal... [read more]
Differentiation of Mesenchymal Stem Cells from Human Induced Pluripotent Stem Cells Results in Downregulation of c-Myc and DNA Replication Pathways with Immunomodulation Toward CD4 and CD8 Cells
February 3, 2018 | rss feed
Multilineage tissue-source mesenchymal stem cells (MSCs) possess strong immunomodulatory properties and are excellent therapeutic agents, but require constant isolation from donors to combat replicative senescence. The differentiation of human induced pluripotent stem cells (iPSCs) into MSCs offers... [read more]
The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia
February 3, 2018 | rss feed
Bone marrow derived mesenchymal stromal cells have been shown to have significant therapeutic effects in experimental models of pneumonia and lung injury. The current study examined the roles of the toll like receptor 4 (TLR4) and protease activated receptor 1 (PAR1) pathways on mesenchymal... [read more]
Fine Tuning of Canonical Wnt Stimulation Enhances Differentiation of Pluripotent Stem Cells Independent of β-Catenin-Mediated T-Cell Factor Signaling
February 3, 2018 | rss feed
The canonical Wnt/β-catenin pathway is crucial for early embryonic patterning, tissue homeostasis, and regeneration. While canonical Wnt/β-catenin stimulation has been used extensively to modulate pluripotency and differentiation of pluripotent stem cells (PSCs), the mechanism of these two... [read more]
Researchers discover gene network that regulates the motor neuron development in growing embryo
February 2, 2018 | rss feed
UCLA researchers have discovered the inner workings of a gene network that regulates the development of spinal motor neurons in the growing chicken and mouse... [read more]
Higher susceptibility of some babies to Zika virus has a genetic origin, study shows
February 2, 2018 | rss feed
Microcephaly, brain calcification, skeletal alterations, auditory and visual deficits - these are examples of the damage that can be caused by Zika virus in babies born to mothers infected during... [read more]
Researchers identify cause of severe genetic disease
February 2, 2018 | rss feed
Mutations in the p63 protein lead to a number of disorders, but none is as severe as the AEC syndrome. Scientists at Goethe University Frankfurt in collaboration with a research group from the University of Naples Federico II have now discovered that... [read more]
Study unravels developmental splicing program that promotes neuronal maturation
February 2, 2018 | rss feed
Neurons, or nerve cells, in the brain communicate with each other by transmitting electric signals, or firing action potentials, through long processes named axons (which send out signals) and dendrites (which receive... [read more]
Neurons get stretches of orderly drumroll-like rumblings speckled with strong impulses
February 2, 2018 | rss feed
A neuron firing deep in the brain might sound a little like: Drumroll...cymbal crash! Drumroll...cymbal crash! Repeat. With emphasis on "repeat," according to a new... [read more]
Study identifies new potential target for treatment of blood disorders
February 1, 2018 | rss feed
UCLA researchers, in collaboration with the University of Iowa, discovered the contribution of a specific gene in the proper development of blood cells that give rise to hematopoietic stem... [read more]
Houston Methodist researchers have new explanation for why airways close during asthma attacks
February 1, 2018 | rss feed
Houston Methodist researchers have a new explanation for what causes the lungs' airways to close during asthma... [read more]
Scientists discover role of two specific HOX genes in colon cancer development
February 1, 2018 | rss feed
In breakthrough colon cancer research, scientists at Christiana Care Health System's Center for Translational Cancer Research of the Helen F. Graham Cancer Center & Research Institute have discovered that over-expression of HOXA4 and HOXA9 genes in... [read more]
Scientists gain better understanding of how the intestine repairs itself after injury
January 31, 2018 | rss feed
Researchers at Baylor College of Medicine, Johns Hopkins University School of Medicine and the University of California, San Francisco have gained new insights into how the small intestine, one of the fastest renewing tissues in the human body,... [read more]
The effects of Huntington’s disease can be seen as early as conception, finds new study
January 30, 2018 | rss feed
In a breakthrough study, scientists at the Rockefeller University have observed the effects of Huntington’s disease in neurons as early as... [read more]
Role of genetics behind immune disease risk could be missed, scientists suggest
January 30, 2018 | rss feed
The role of genetics in the risk of having an immune disease could be missed in research, scientists... [read more]
Rockefeller scientists develop system to model Huntington’s in human embryonic stem cells
January 29, 2018 | rss feed
With new findings, scientists may be poised to break a long impasse in research on Huntington's disease, a fatal hereditary disorder for which there is currently no... [read more]
Discovery may offer new therapeutic approach for kids with Prader-Willi syndrome
January 28, 2018 | rss feed
Stem cell researchers at UConn Health have reversed Prader-Willi syndrome in brain cells growing in the lab, findings they recently published in the Human Molecular... [read more]
Inhibition of Aldehyde Dehydrogenase-Activity Expands Multipotent Myeloid Progenitor Cells with Vascular Regenerative Function
January 27, 2018 | rss feed
Blood-derived progenitor cell transplantation holds potential for the treatment of severe vascular diseases. Human umbilical cord blood (UCB)-derived hematopoietic progenitor cells purified using high aldehyde dehydrogenase (ALDHhi) activity demonstrate pro-angiogenic functions following... [read more]
Reduced Cell Division Control Protein 42 Activity Compromises Hematopoiesis-Supportive Function of Fanconi Anemia Mesenchymal Stromal Cells
January 27, 2018 | rss feed
Hematopoietic stem cells preserve their ability to self-renew and differentiate to different lineages in the bone marrow (BM) niche, which is composed in large part by BM stromal cells. Studies have shown that altered signaling in the BM niche results in leukemia initiation or progression. Fanconi... [read more]
Biotechnology startup receives FDA clearance for synthetic bone graft substitute
January 27, 2018 | rss feed
A biotechnology startup enabled by UC Davis, Molecular Matrix Inc., has received Food and Drug Administration clearance for a carbohydrate-based polymer that can help injured bones heal and... [read more]
How does high cholesterol cause cancer? Study sheds light
January 26, 2018 | rss feed
Researchers have discovered a cell mechanism in which cholesterol influences the proliferation of stem cells and the growth of intestinal tumors in... [read more]
How does high cholesterol cause cancer? Study sheds light
January 26, 2018 | rss feed
Researchers have discovered a cell mechanism in which cholesterol influences the proliferation of stem cells and the growth of intestinal tumors in... [read more]
Research could explain link between high-cholesterol diet and increased colon cancer risk
January 26, 2018 | rss feed
New UCLA research could help explain the link between a high-cholesterol diet and an elevated risk for colon... [read more]
Researchers find new method to overcome major challenge of stem cell therapy
January 26, 2018 | rss feed
Researchers have discovered a new technique that overcomes one of the major challenges of stem cell... [read more]
Repurposed drug effectively protects against Zika virus in mouse models
January 26, 2018 | rss feed
In both cell cultures and mouse models, a drug used to treat Hepatitis C effectively protected and rescued neural cells infected by the Zika virus -- and blocked transmission of the virus to mouse... [read more]
Cover Image
January 25, 2018 | rss feed
Cover Art: Adipose tissue-derived stromal cells (ASC) induce endothelial cells vessel-like network formation in three-dimensional microenvironments. ASC (CM-Dil-labeled, red) and HUVEC (PECAM-1, green) were embedded in Matrigel. Nuclei were stained... [read more]
Researchers grow human trophoblast stem cells for the first time
January 25, 2018 | rss feed
In a milestone achievement for better understanding the development and function of the human placenta, scientists have derived and grown trophoblast stem cells for the first... [read more]
Discovery may advance stem cell therapies, gene-targeting treatments for neurological diseases
January 25, 2018 | rss feed
New research from Sanford Burnham Prebys Medical Discovery Institute is among the first to describe how an mRNA modification impacts the life of neural stem... [read more]
CD34 protein found to be much more than a stem cell marker
January 24, 2018 | rss feed
A protein used to identify blood-forming cells is much more than a mere surface marker. A KAUST study shows that this protein, known as CD34, also plays a key role in binding adhesion molecules in the bone... [read more]
TSRI scientists identify factors crucial to mesenchymal stem cell differentiation
January 24, 2018 | rss feed
Researchers at The Scripps Research Institute recently published a study in the journal Cell Death and Differentiation identifying factors crucial to mesenchymal stem cell differentiation, providing insight into how these cells should be studied for... [read more]
Scientists take tissue-engineering approach to improve healing related to skeletal system
January 23, 2018 | rss feed
"Take a knee." "On bended knee." A "knee-slapper." "The bee's knees." The knee certainly carries a lot of weight in the English language, just as it does in the body. As the largest and one of the most complicated joints, the knee is also one of the... [read more]
Wnt/β-Catenin/TCF Pathway Is a Phase-Dependent Promoter of Colony Formation and Mesendodermal Differentiation During Human Somatic Cell Reprogramming
January 23, 2018 | rss feed
Somatic cell reprogramming is a biphasic phenomenon that goes through a mesenchymal-to-epithelial transition, called initiation phase, followed by a maturation phase wherein reprogramming cells acquire pluripotency. Here, we show that these phases display a differential response to Wnt signaling... [read more]
Store-Operated Calcium Entries Control Neural Stem Cell Self-Renewal in the Adult Brain Subventricular Zone
January 23, 2018 | rss feed
The subventricular zone (SVZ) is the major stem cell niche in the brain of adult mammals. Within this region, neural stem cells (NSC) proliferate, self-renew and give birth to neurons and glial cells. Previous studies underlined enrichment in calcium signaling-related transcripts in adult NSC.... [read more]
Cotransplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair
January 20, 2018 | rss feed
Patients suffering from spinal cord injury (SCI) still have a dismal prognosis. Despite all the efforts developed in this area, currently there are no effective treatments. Therefore, cell therapies have been proposed as a viable alternative to the current treatments used. Adipose tissue-derived... [read more]
Concise Review: Resistance to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer: The Role of Cancer Stem Cells
January 20, 2018 | rss feed
Among the potential mechanisms involved in resistance to tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer, the manifestation of stem-like properties in cancer cells seems to have a crucial role. Alterations involved in the development of TKI resistance may be acquired in a very early... [read more]
AMSBIO offers isogenic panels of neuronal iPSC derivatives
January 19, 2018 | rss feed
For several years, neuroscience research using cell line and animal models of degenerative neurological disorders such as Parkinson’s and Alzheimer’s disease has been challenged to translate results into in vivo conditions, whether for basic... [read more]
Modular gene enhancers may be suitable target in treatment of blood cancer
January 18, 2018 | rss feed
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in... [read more]
Concise Review: Human Induced Pluripotent Stem Cell Models of Retinitis Pigmentosa
January 18, 2018 | rss feed
Hereditary retinal dystrophies, specifically retinitis pigmentosa (RP) are clinically and genetically heterogeneous diseases affecting primarily retinal cells and retinal pigment epithelial cells with blindness as a final outcome. Understanding the pathogenicity behind these diseases has been... [read more]
Three-dimensional organization of genome plays key role in gene expression, cell fate
January 17, 2018 | rss feed
Scientists have long been reading the code of life - the genome -, as a sequence of letters but now researchers have also started exploring its three-dimensional... [read more]
EXD2 enzyme facilitates protein production in mitochondria
January 17, 2018 | rss feed
Researchers from the Genomic Instability and Cancer Laboratory at Institute for Research in Biomedicine (IRB Barcelona) have identified a key role for EXD2 in protein production in the mitochondria, the cellular organelles responsible for the majority... [read more]
Immunomodulation By Therapeutic Mesenchymal Stromal Cells (MSC) Is Triggered Through Phagocytosis of MSC By Monocytic Cells
January 17, 2018 | rss feed
Mesenchymal stem or stromal cells (MSC) are under investigation as a potential immunotherapy. MSC are usually administered via intravenous infusion, after which they are trapped in the lungs and die and disappear within a day. The fate of MSC after their disappearance from the lungs is unknown and... [read more]
Cornea-Derived Mesenchymal Stromal Cells Therapeutically Modulate Macrophage Immunophenotype and Angiogenic Function
January 17, 2018 | rss feed
Macrophages are crucial drivers of inflammatory corneal neovascularization and thus are potential targets for immunomodulatory therapies. We hypothesized that therapeutic use of cornea-derived mesenchymal stromal cells (cMSCs) may alter the function of macrophages. We found that cMSCs can modulate... [read more]
Epigenetic Silencing of TAP1 in Aldefluor+ Breast Cancer Stem Cells Contributes to Their Enhanced Immune Evasion
January 17, 2018 | rss feed
Avoiding detection and destruction by immune cells is key for tumor initiation and progression. The important role of cancer stem cells (CSCs) in tumor initiation has been well established, yet their ability to evade immune detection and targeting is only partly understood. To investigate the... [read more]
AMSBIO’s new recombinant protein shows great promise for organoid culture
January 16, 2018 | rss feed
AMSBIO has introduced recombinant Wnt3a with a new Wnt stabilizer that significantly extends the activity of this protein in serum-free medium from a half-life of just 2 hours to around 30... [read more]
AMSBIO’s new recombinant protein shows great promise for organoid culture
January 16, 2018 | rss feed
AMSBIO has introduced recombinant Wnt3a with a new Wnt stabilizer that significantly extends the activity of this protein in serum-free medium from a half-life of just 2 hours to around 30... [read more]
Concise Review: Optimized Strategies for Stem Cell-Based Therapy in Myocardial Repair: Clinical Translatability and Potential Limitation
January 13, 2018 | rss feed
Ischemic heart diseases (IHDs) remain major public health problems with high rates of morbidity and mortality worldwide. Despite significant advances, current therapeutic approaches are unable to rescue the extensive and irreversible loss of cardiomyocytes caused by severe ischemia. Over the past... [read more]
Stem cell transplant can effectively treat patients with rare autoimmune disease, study shows
January 13, 2018 | rss feed
An unusual autoimmune disease that causes skin and lung damage can be treated effectively by stem cell transplant, a new study in the New England Journal of Medicine has... [read more]
Research provides insights into mechanisms governing healthy longevity
January 12, 2018 | rss feed
Keio University Global Research Institute, Tokyo publishes the January 2018 issue of KGRI Research Frontiers that includes researcher video profiles of Keio University researchers and research highlights from high impact publications including... [read more]
ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells
January 12, 2018 | rss feed
Developmental Pluripotency-Associated-4 (DPPA4) is one of the few core pluripotency genes lacking clearly defined molecular and cellular functions. Here, we used a proteomics screening approach of human embryonic stem cell (hESC) nuclear extract to determine DPPA4 molecular functions through... [read more]
Poly(Lactide-Co-Glycolide)-Monomethoxy-Poly-(Polyethylene Glycol) Nanoparticles Loaded with Melatonin Protect Adipose-Derived Stem Cells Transplanted in Infarcted Heart Tissue
January 12, 2018 | rss feed
Stem cell transplantation is a promising therapeutic strategy for myocardial infarction. However, transplanted cells face low survival rates due to oxidative stress and the inflammatory microenvironment in ischemic heart tissue. Melatonin has been used as a powerful endogenous antioxidant to... [read more]
Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-Derived Retinal Organoids and Fetal Retinae
January 12, 2018 | rss feed
Loss of photoreceptor cells due to retinal degeneration is one of the main causes of blindness in the developed world. Although there is currently no effective treatment, cell replacement therapy using stem-cell-derived photoreceptor cells may be a feasible future treatment option. In order to... [read more]
UCLA scientists coax human stem cells to become sensory interneurons
January 12, 2018 | rss feed
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons -- the cells that give us our sense of... [read more]