From 1908 when their existence was first hypothesized and the name “Stem Cell” was coined, it was then 70 years before definitive proof of their existence was shown in 1978. In the decades since then, research employing Stem Cells as treatments and therapies has exploded off the charts with research being conducted on nearly all the continents. The staff at StemCell101.com is dedicated to combing the internet, trade journals, and medical publications to bring consumers the latest information and news about this exciting and promising field.

stemcell-research 

The following are just some examples of the Worldwide Research Effort:

AFRICA

South Africa
In March 2012 scientists at South Africa’s Council for Scientific and Industrial Research (CSIR) set up a facility for biomedical stem cell technology. Its gene expression and biophysics group generated the first induced pluripotent stem cells (iPSCs) in Africa, the CSIR announced.

ASIA

China
China holds unrestrictive policies in regard to embryonic stem cell research – one of the most unrestrictive in the world. With this atmosphere Chinese scientists who have been educated and been trained in the West have flocked back to set up stem cell research laboratories in their home country. Stem cell researchers in the West attest to the fact that stem cell research facilities and researchers in China are already world class.

India
In Bangalore, India, the Institute for Stem Cell Biology and Regenerative Medicine (inStem) has state-of-the-art research facilities. Research at inStem includes stem cell biology, looking into mechanism that control differentiation and renewal, and impact of stem cells on recovery from stroke. Also in India, the Chaitanya Stem Cell Centre gives information on neurology, kidney, liver and many untreatable diseases. It also pushes regenerative medicine..

Japan
The following report is derived from the editorial. “New horizon in stem cell research,” of The Japan Times, February 3,2014 issue. Dr. Haruko Obokata and her team have found that body cells taken from mice can be reprogrammed into stem cells by exposing them to low-PH acid liquids. This new way of reprogramming adult cells into pluripotent cells (embryonic stem cells) is called “stimulus-triggered acquisition of pluripotency” or STAP. The STAP method is easier than that used by Dr. Shinya Yamanaka of Kyoto University, co-recipient with Sir John Gurdon of the Nobel Prize in Physiology or Medicine in 2012. In 2006 Yamanaka produced embryonic stem cells out of mouse skin by introducing four genes as growth factors. The cells are called induced pluripotent stem cells (iPSC). Yamanaka and his team did the same on human skin cells in 2007. STAP cells can form placenta which iPSC cannot do. “It is hoped that more efforts will be made so that the discovery will lead to the advancement of regenerative medicine.”

South Korea
The Stem Cell Research Center (SCRC) is a government-funded organization that supports stem cell research.The SCRC acts is a funding agency with 52 projects throughout South Korea. A national network, the Korean Society for Stem Cell Research, has been set up to facilitate stem cell research. The Stem Cell Research Center is the biggest stem cell center supported by Ministry of Science and Technology. Several other centers are supported by ministries like the Ministry of Health and Welfare. Several non-government organizations support stem cell research.

stemcellresearch-australiaAUSTRALIA

Some stem cell research trials being conducted in Australia include…..

[lists bullet=”square” type=”style1″]

  • Condition: Graft Versus Host Disease. Mesenchymal Stromal Cells for Acute Graft Versus Host Disease. The trial plans to enrol 66 patients by December 2015 and to be completed by December 2016.
  • Condition: Osteoarthritis. HiQCell Joint Registry in Patients with Osteoarthritis Following the HiQCell Procedure. The first patients underwent this procedure in July 2012.
  • Condition: Brain tumours. Gene Therapy and Chemotherapy for the Treatment of Childhood Brain Tumours. The trial commenced in July 2012.
  • Condition: Bone repair. Cranial Reconstruction Using Mesenchymal Stromal Cells and Resorbable Biomaterials. This trial is conducted at the Royal Perth Hospital in Western Australia from January 2013 to December 2015.
  • Condition: Leukaemia. Pilot Study of Partially Human Leucocyte Antigen-Mismatched Stem Cell Infusions after Chemotherapy for Acute Myeloid Leukaemia.
  • Condition: Osteoarthritis. The Osteoarthritis Stem Cell Advanced Research Study. This trial is conducted by the Rheumatology Department of the Royal North Shore Hospital St Leonards in New South Wales and Regeneus Pty Ltd. (Internet. March 10,2014)

[/lists]

EUROPE

Belgium
Belgian medical researchers succeeded in repairing bones using stem cells from fatty tissue.

The Saint Luc university clinic hospital in Brussels has a team that “has treated 11 patients, eight of them children, with fractures or bone defects that their bodies could not repair….” This was reported by the university on January 14, 2014. The breakthrough technique of Saint Luc’s centre for tissue and cellular therapy consists in removing a “sugar cube sized piece of fatty tissue from the patient, a less invasive process than pushing a needle into the pelvis and with a stem cell concentration they say is some 500 times higher.”

France
“The national assembly of France has voted to a lift a ban on embryonic stem cell research, which could pave the way for crucial scientific developments.” (France lifts its ban on embyonic stem cell reserch by Rebecca Taylor | Paris, France | LifeNews.com | 7/17/13)

I-Stem is the largest French laboratory for research and development devoted to embryonic origin obtained by reprogramming gene. It is a collaboration between Inserm – National Institute of Health and Medical Research – and AFM-Telethon – French Association against Myopathies.

Germany
Germany defines stem cell research as “the scientific study of embryonic, fetal, adult, as well as induced pluripotent stem cells of living organisms of all kinds. By definition, stem cells are cells that are not yet fully developed and therefore have the potential to differentiate into different cell types.” In the medical and biological fields findings in stem cell research are obtained and turned to benefit consumers. The ultimate goal is regenerating defective organs.

Spain
Spain has a comprehensive regulatory framework for stem cell research, consisting of laws and regulations on stem cell research. One partner in research is the Centre for Genomic Regulation. This is reported by “Regulation of stem cell research in Spain,” updated in August 2012.

United Kingdom
Stem cell researchers of the United Kingdom “fertilised (the) first animal and then human eggs outside the body; a discovery that led to the creation of embryos outside the body and the subsequent birth of the first ‘test-tube baby’ (in vitro fertilisation) in 1978.” (www.mrc-centre.cam.ac.uk)

A British researcher, Sir John Gurdon, opened the door for animal cloning with the reprogramming of frog egg nucleus. He is co-winner of Shinya Yamanaka of Nobel Prize in Medicine in 2012 for their stem cell research.

The UK had pioneered in setting up a stem cell bank. “Set up in 2002 and partly funded by the MRC, the bank reduces the requirement for surplus embryos for the development of stem cell lines by individual research groups” (Internet. March 10,2014).
Researchers will go into guided differentiation into desired adult cells like muscles of the heart.

The potential of stem cells in screening drugs will be looked into. This may reduce the need to go through animal testing.
The Research Councils and Technology Strategy Board have agreed to develop regenerative medicine.

NORTH AMERICA

Canada
In 1963, Canadian scientists James Till and Ernest McCulloch identified and named stem cells. Since then Canadians have been at the forefront of scientific research, according to CBC digital archives (Internet March 10,2014).

Dr. Andras Nagy and his colleagues at Toronto’s Mount Sinai Hospital developed a method of turning skin cell into stem cells.” The new reprogramming method replaces a process that until now was done using viruses and carried the risk of damaging cell DNA and causing cancer.”

Stem cell DNA are inserted into a skin cell and ”removed after the skin cell transforms into a stem cell.” The produced stem cells are safer; the use of embryonic stem cells is not needed. This was announced in 2009 (Internet. March 10, 2014)

United States

“US President Barack Obama has reversed some barriers to human embryonic stem cell research,” in March 2009. This reversed the ban by Pres. Bill Clinton in 1995 owing to the ethical controversy over the use of human embryonic stem cells, according to the editorial of the Nature Cell Biology in 2010. “On August 23, 2012, in a decision favorable to proponents of embryonic stem cell research, the U.S. Court of Appeals for the D.C. Circuit… (dismissed) a lawsuit that challenged the Obama administration’s expansion of federal funding for embryonic stem cell research” (Internet, March 10,2014).”…Much remains to be done to ensure that stem cell research flourishes in the US in the coming decades,” the editorial said.

With the advent of the use of induced pluripotent stem cells research in stem cell therapy has advanced. However, since this therapy is considered to fall under drugs by the Food and Drug Administration of the USA, it will take long before this therapy becomes available to US consumers.

stemcellresearch-central-americaCENTRAL AMERICA

Panama
The Stem Cell Institute “arose from the unmet need to provide stem cell therapies that have been shown by others to meet the bar of safety in Phase I trials, but are not yet widely available because efficacy has not been proven.” It was founded by Neil Riordan, Ph.D. who comes from an American biotechnology company. Since 2006 the Institute has treated over 1800 patients. Dr. Riordan is the inventor of a nutritional supplement for use in stem cell therapy – Stem-Kine. It increases the population of stem cells and endothelium progenitor cells (EPC) in the bone marrow. EPCs circulate the stem cells to home to damaged part of the body and promotes healing.

“We collaborate with doctors and scientists at major universities in the US, Canada, and Costa Rica; including the University of California, San Diego, University of Utah, University of Western Ontario, University of Florida, University of Massachusetts, and the University of Costa Rica. We are in the planning stages of performing clinical trials in collaboration with New York University and the University of Miami” according to the Stem Cell Institute (Internet. March 10,2014).

SOUTH AMERICA

Brazil
The Brazilian government has set up a national Review Board system to increase research activity and the prospect of treating chronic and degenerative diseases using cell therapy since 2010.

The Science and Technology Department of the Ministry of Health in collaboration with the National Research Council have funded more than 100 projects since 2005. Several groups constitute the Brazilian Cell Therapy Network to promote interaction among research laboratories. “Around US$50 million have been disbursed to the Network by the government between 2005 and 2010” (Internet. March 10,2014).

Global Stem Cell News

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New pig model for stroke could accelerate drug discovery process
September 26, 2017 | rss feed
It is well-known in the medical field that the pig brain shares certain physiological and anatomical similarities with the human brain. So similar are the two that researchers at the University of Georgia's Regenerative Bioscience Center have... [read more]
Conceptualizing Paralogous Stem-Cell Niches and Unfolding Bone Marrow Progenitor Cell Identities
September 26, 2017 | rss feed
Lineage commitment and differentiation of skeletal stem cells/bone marrow stromal cells (SSCs/BMSCs, often called bone marrow-derived “mesenchymal stem/stromal” cells) offer an important opportunity to study skeletal and hematopoietic diseases, and for tissue engineering and regenerative... [read more]
Conceptualizing Paralogous Stem-Cell Niches and Unfolding Bone Marrow Progenitor Cell Identities
September 26, 2017 | rss feed
Lineage commitment and differentiation of skeletal stem cells/bone marrow stromal cells (SSCs/BMSCs, often called bone marrow-derived “mesenchymal stem/stromal” cells) offer an important opportunity to study skeletal and hematopoietic diseases, and for tissue engineering and regenerative... [read more]
Cover Image
September 23, 2017 | rss feed
Cover Art: Skeletal preparation of WT (left), Runx2/(knockout [KO], right), and embryonic stem cell-injected KO blastocyst (KO+ESC) E18.5 embryos (middle). See Chubb et al. beginning on page... [read more]
‘Labyrinth’ chip may be new way to monitor cancer patients in clinical trials
September 22, 2017 | rss feed
Inspired by the Labyrinth of Greek mythology, a new chip etched with fluid channels sends blood samples through a hydrodynamic maze to separate out rare circulating cancer cells into a relatively clean stream for analysis. It is already in use in a... [read more]
Research sheds light on how to improve production of key diabetes cells
September 21, 2017 | rss feed
Beta cells release insulin in your blood, but when you suffer from Type 1 diabetes, you hardly have any of them left in your body. This is because the immune system attacks the beta... [read more]
Scientists use genome editing to understand role of a gene key to human embryonic development
September 21, 2017 | rss feed
Researchers have used a genome-editing technique to elucidate the role of a gene that is key to human embryonic... [read more]
Encapsulating stem cells in nanogel could help repair damage to the heart
September 20, 2017 | rss feed
Heart disease and heart-related illnesses are a leading cause of death around the world, but treatment options are limited. Now, one group reports in ACS Nano that encapsulating stem cells in a nanogel could help repair damage to the... [read more]
Researchers identify role of tumor-infiltrating B-cells in melanoma progression, resistance to therapy
September 20, 2017 | rss feed
In a multi-institutional collaborative study, scientists at The Wistar Institute and the Medical University of Vienna, Austria, have identified the role of tumor-infiltrating or tumor-associated B-cells ("TABs") in melanoma progression and resistance... [read more]
Study overturns common belief about how proteins regulate formation of sensory interneurons
September 20, 2017 | rss feed
A recent study led by Samantha Butler at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA has overturned a common belief about how a certain class of proteins in the spinal cord regulate the formation of nervous... [read more]
Research provides insight into how imbalance in neural precursor cells may contribute to brain diseases
September 15, 2017 | rss feed
Salk Institute scientists have discovered that an interaction between two key proteins helps regulate and maintain the cells that produce... [read more]
Bone Marrow Stem Cells do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models
September 15, 2017 | rss feed
Studies from five independent laboratories conclude that bone marrow stem cells transdifferentiate into endometrial stroma, epithelium and endothelium. We investigated the nature of bone marrow-derived cells in the mouse endometrium by reconstituting irradiated wild type recipients with bone marrow... [read more]
An iPSC Patient Specific Model of CFH (Y402H) Polymorphism Displays Characteristic Features of AMD and Indicates a Beneficial Role for UV Light Exposure
September 15, 2017 | rss feed
Age related macular degeneration (AMD) is the most common cause of blindness, accounting for 8.7% of all blindness globally. Vision loss is caused ultimately by apoptosis of the retinal pigment epithelium (RPE) and overlying photoreceptors. Treatments are evolving for the wet form of the disease,... [read more]
MSC transplantation can be safe, effective approach to treat Crohn’s disease-related fistula
September 14, 2017 | rss feed
A growing body of clinical evidence shows that transplantation of a patient's own mesenchymal stem cells (MSCs) to achieve a cure and prevent recurrent of Crohn's disease-related fistula can be a safe and effective addition to... [read more]
Leeds Teaching Hospitals to introduce private stem cell collection and storage option for patients
September 14, 2017 | rss feed
The Leeds Teaching Hospitals NHS Trust is continually striving to provide high quality, patient centred care to each and every patient. Smart Cells International, in association with the trust, will be introducing the option for patients to privately store stem cells from the umbilical cord across... [read more]
Gene-edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development
September 14, 2017 | rss feed
A critical event during kidney organogenesis is the differentiation of podocytes, specialized epithelial cells that filter blood plasma to form urine. Podocytes derived from human pluripotent stem cells (hPSC-podocytes) have recently been generated in nephron-like kidney organoids, but the... [read more]
Gene-edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development
September 14, 2017 | rss feed
A critical event during kidney organogenesis is the differentiation of podocytes, specialized epithelial cells that filter blood plasma to form urine. Podocytes derived from human pluripotent stem cells (hPSC-podocytes) have recently been generated in nephron-like kidney organoids, but the... [read more]
MZF1 and GABP Cooperate with Sox2 in Regulating the Expression of YAP1 in Cancer Cells
September 14, 2017 | rss feed
The transcription factor YAP1 is a major effector of the tumor suppressive Hippo signaling pathway and is also necessary to maintain pluripotency in embryonic stem cells. Elevated levels of YAP1 expression antagonize the tumor suppressive effects of the Hippo pathway, that normally represses YAP1... [read more]
MZF1 and GABP Cooperate with Sox2 in Regulating the Expression of YAP1 in Cancer Cells
September 14, 2017 | rss feed
The transcription factor YAP1 is a major effector of the tumor suppressive Hippo signaling pathway and is also necessary to maintain pluripotency in embryonic stem cells. Elevated levels of YAP1 expression antagonize the tumor suppressive effects of the Hippo pathway, that normally represses YAP1... [read more]
NSF grant to support development of brain-machine interface to restore walking in people with paraplegia
September 14, 2017 | rss feed
People with paraplegia due to spinal cord injury may eventually get a chance to suit up, walk out the door and feel the ground beneath their feet, thanks to a five-year, $8 million Cyber-Physical Systems Frontier grant from the National Science... [read more]
Disrupting DNA loops could be potential strategy to reduce tumor proliferation
September 13, 2017 | rss feed
The discovery of a mechanism by which normal brain cells regulate the expression of the NFIA gene, which is important for both normal brain development and brain tumor growth, might one day help improve therapies to treat brain tumors. The study... [read more]
NIH grant supports temple researchers’ exploration of stem cell-based treatments for heart repair
September 13, 2017 | rss feed
The incidence of heart disease is on the rise, and new therapeutic strategies are needed. Approaches based on stem cells, which can potentially preserve or even regenerate heart muscle cells damaged by ischemia - a hallmark of heart disease - are... [read more]
New testing regime could speed up diagnosis and treatment of SCID in infants
September 13, 2017 | rss feed
Babies born with Severe Combined Immune Deficiency (SCID) syndrome are defenceless against bacterial and viral infections that would be virtually harmless to most healthy people. If untreated, SCID is often fatal within a baby's first year of... [read more]
Research uncovers new target for therapy, diagnosis, and prognosis of colon cancer
September 13, 2017 | rss feed
Genetic research conducted at LSU Health New Orleans School of Medicine and Stanley S. Scott Cancer Center demonstrated for the first time that a novel protein can cause normal cells in the lining of the colon to become malignant, grow and spread, as... [read more]
TSRI scientists find new approach to reprogram ordinary adult cells into IPSCs
September 12, 2017 | rss feed
Scientists at The Scripps Research Institute have found a new approach to the "reprogramming" of ordinary adult cells into stem... [read more]
UBR2 Enriched in P53-/-mBMMSC-Exosome Promoted Gastric Cancer Progression via Wnt/β-catenin Pathway
September 12, 2017 | rss feed
The deficiency or mutation of p53 has been known to be linked to several types of cancers. Mesenchymal stem cell (MSC) is an important component in tumor microenvironment and exosomes secreted by MSCs can transfer bioactive molecules including proteins and nucleic acid to another cells in tumor... [read more]
RUNX2 Induction during Differentiation of Wharton’s Jelly Mesenchymal Stem Cells to Osteoblasts is Regulated by JARID1B Histone Demethylase
September 12, 2017 | rss feed
Novel bone regeneration approaches aim to obtain immature osteoblasts from somatic stem cells. Umbilical cord Wharton's jelly mesenchymal stem cells (WJ-MSC) are an ideal source for cell therapy. Hence, the study of mechanisms involved in WJ-MSC osteoblastic differentiation is crucial to exploit... [read more]
Genetic Evolution of Glioblastoma Stem-Like Cells from Primary to Recurrent Tumor
September 12, 2017 | rss feed
Glioblastoma (GBM) is a lethal tumor that displays remarkable genetic heterogeneity. It is also known that GBM contains a cell hierarchy driven by stem-like cells (GSCs), responsible for tumor generation, therapeutic resistance and relapse. An important and still open issue is whether... [read more]
Penn researchers find abnormally shortened telomeres in young DMD patients’ muscle stem cells
September 7, 2017 | rss feed
Researchers from the Perelman School of Medicine at the University of Pennsylvania have made a discovery about muscular dystrophy disorders that suggest new possibilities for... [read more]
Scientists directly convert skin cells from healthy adults into motor neurons
September 7, 2017 | rss feed
Scientists working to develop new treatments for neurodegenerative diseases have been stymied by the inability to grow human motor neurons in the lab. Motor neurons drive muscle contractions, and their damage underlies devastating diseases such as... [read more]
New human stem cell model could pave way for macular degeneration research
September 7, 2017 | rss feed
Macular degeneration is the leading cause of vision loss in older adults, but scientists have long struggled to study and replicate key elements of the disease in the... [read more]
Researcher develops bone marrow models to study hematological and musculoskeletal diseases
September 6, 2017 | rss feed
For her research on the development of hematological and musculoskeletal disorders, Dr. Cornelia Lee-Thedieck, scientist at Karlsruhe Institute of Technology, is awarded an ERC Starting Grant: The European Research Council decided to fund her project... [read more]
Monkeys with Parkinson’s disease benefit from human stem cells
September 5, 2017 | rss feed
One of the last steps before treating patients with an experimental cell therapy for the brain is confirmation that the therapy works in... [read more]
Monkeys with Parkinson’s disease benefit from human stem cells
September 5, 2017 | rss feed
One of the last steps before treating patients with an experimental cell therapy for the brain is confirmation that the therapy works in... [read more]
Monkeys with Parkinson’s disease benefit from human stem cells
September 5, 2017 | rss feed
One of the last steps before treating patients with an experimental cell therapy for the brain is confirmation that the therapy works in... [read more]
Monkeys with Parkinson’s disease benefit from human stem cells
September 5, 2017 | rss feed
One of the last steps before treating patients with an experimental cell therapy for the brain is confirmation that the therapy works in... [read more]
Concise Reviews: Kidney Generation with Human Pluripotent Stem Cells
September 4, 2017 | rss feed
Chronic kidney disease (CKD) is a world-wide healthcare problem, resulting in increased cardiovascular mortality and often leading to end-stage kidney disease (ESKD) where patients require kidney replacement therapies such as hemodialysis or kidney transplantation. Loss of functional nephrons... [read more]
Bone Morphogenetic Protein Promotes Lewis X Stage-Specific Embryonic Antigen 1 Expression Thereby Interfering with Neural Precursor and Stem Cell Proliferation
September 4, 2017 | rss feed
The glycoprotein Prominin-1 and the carbohydrate Lewis X stage-specific embryonic antigen 1 (LeX-SSEA1) both have been extensively used as cell surface markers to purify neural stem cells (NSCs). While Prominin-1 labels a specialized membrane region in NSCs and ependymal cells, the specificity of... [read more]
RUNX1c Regulates Hematopoietic Differentiation of Human Pluripotent Stem Cells Possibly in Cooperation with Proinflammatory Signaling
September 4, 2017 | rss feed
Runt-related transcription factor 1 (Runx1) is a master hematopoietic transcription factor essential for hematopoietic stem cell (HSC) emergence. Runx1-deficient mice die during early embryogenesis due to the inability to establish definitive hematopoiesis. Here, we have used human pluripotent stem... [read more]
Parkinson’s: Asthma drugs may cut risk by a third
September 1, 2017 | rss feed
A study including cell cultures, experiments in mice, and an overview of more than 100 million prescriptions shows asthma drugs lower Parkinson's risk.... [read more]
Parkinson’s: Asthma drugs may cut risk by a third
September 1, 2017 | rss feed
A study including cell cultures, experiments in mice, and an overview of more than 100 million prescriptions shows asthma drugs lower Parkinson's risk.... [read more]
St. Kitts launches probe of herpes vaccine tests on U.S. patients
August 31, 2017 | rss feed
The government of St. Kitts and Nevis has launched an investigation into the clinical trial for a herpes vaccine by an American company because it said its officials were not notified about the... [read more]
UChicago Medicine working with Novartis to offer breakthrough gene therapy for pediatric ALL patients
August 31, 2017 | rss feed
The University of Chicago Medicine is one of a limited number of U.S. sites working to offer a breakthrough gene therapy for pediatric acute lymphoblastic leukemia (ALL), which was just approved by the U.S. Food and Drug... [read more]
Feeder-free stem cell culture media now available from AMSBIO
August 31, 2017 | rss feed
AMSBIO announces the availability of StemFit® Basic02 feeder-free stem cell culture... [read more]
Parkinson’s: Stem cells restore nerve function in monkeys
August 31, 2017 | rss feed
Scientists have created dopaminergic neurons from human stem cells and implanted them in monkeys with Parkinson's, restoring their nerve function.... [read more]
Parkinson’s: Stem cells restore nerve function in monkeys
August 31, 2017 | rss feed
Scientists have created dopaminergic neurons from human stem cells and implanted them in monkeys with Parkinson's, restoring their nerve function.... [read more]
Olfactory tissue regeneration requires inflammatory processes that create loss of smell
August 31, 2017 | rss feed
In a mouse study designed to understand how chronic inflammation in sinusitis damages the sense of smell, scientists at Johns Hopkins say they were surprised to learn that the regeneration of olfactory tissue requires some of the same inflammatory... [read more]
Reprogrammed stem cell therapy shows promise in Parkinson’s
August 31, 2017 | rss feed
Japanese investigators have found that their experimental stem cell therapy for Parkinson’s disease actually works. In their experimental therapy, the team of researchers “reprogrammed” stem cells to make them neurons and implanted them into the brain of monkeys with a version of... [read more]
Novartis gets FDA approval for novel immunocellular therapy to treat relapsed or refractory B-cell ALL
August 31, 2017 | rss feed
Novartis announced today that the US Food and Drug Administration has approved Kymriah (tisagenlecleucel) suspension for intravenous infusion, formerly CTL019, the first chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of patients... [read more]
MIT engineers devise automated approach to monitor neurons
August 30, 2017 | rss feed
Recording electrical signals from inside a neuron in the living brain can reveal a great deal of information about that neuron's function and how it coordinates with other cells in the... [read more]
New review explores potential of fetal membranes for regenerative medicine
August 30, 2017 | rss feed
A new review looks at the potential of fetal membranes, which make up the amniotic sac surrounding the fetus during pregnancy, for regenerative... [read more]
Human ancestors responsible for transmitting ancient strains of herpesvirus, study finds
August 30, 2017 | rss feed
An international study of integrated HHV-6 has discovered that a small number of human ancestors, one from about 24,000 years ago, have been responsible for transmitting ancient strains of the virus to individuals today - affecting about a million... [read more]
Human ancestors responsible for transmitting ancient strains of herpesvirus, study finds
August 30, 2017 | rss feed
An international study of integrated HHV-6 has discovered that a small number of human ancestors, one from about 24,000 years ago, have been responsible for transmitting ancient strains of the virus to individuals today - affecting about a million... [read more]
Concise Review: Mechanisms of Quiescent Hair Follicle Stem Cell Regulation
August 30, 2017 | rss feed
Maintaining a pool of adult stem cells is essential for tissue homeostasis and wound repair. In mammalian tissues, notably hair follicles, blood, and muscle, stem cells acquire quiescence and infrequently divide for self-renewal. Mechanistic understanding of stem cell quiescence is critical for... [read more]
Mesenchymal Stromal/Stem Cells: A New Treatment for Sepsis and Septic Shock?
August 30, 2017 | rss feed
Sepsis and septic shock are the leading cause of admission and mortality in non-coronary intensive care units. Currently, however, no specific treatments are available for this syndrome. Due to the failure of conventional treatments, in recent years, research is focussing on innovative therapeutic... [read more]
Scientists identify novel role for retrotransposons in shaping embryonic chromatin landscape
August 30, 2017 | rss feed
Retrotransposons are repetitive elements that form almost half of the mammalian genome. Even though they are so common, they have previously been considered to be fairly... [read more]
Extensive analysis reveals immune system dynamics after stem cell transplantation in leukemia patients
August 29, 2017 | rss feed
By combining new system-biological analyses and advanced data analysis, researchers at Karolinska Institutet have been able to monitor the maturation process of the immune system of leukemia patients who have undergone stem cell... [read more]
Targeting bone marrow protein could be effective way to improve stem cell transplants
August 29, 2017 | rss feed
Bone marrow contains hematopoetic stem cells, the precursors to every blood cell type. These cells spring into action following bone marrow transplants, bone marrow injury and during systemic infection, creating new blood cells, including immune... [read more]
FDA issues warning letter to US Stem Cell Clinic for significant deviations
August 28, 2017 | rss feed
The U.S. Food and Drug Administration today posted a warning letter issued to US Stem Cell Clinic of Sunrise, Florida, and its Chief Scientific Officer Kristin Comella for marketing stem cell products without FDA approval and for significant... [read more]
Biomedical engineering researchers aim to attack two banes of cardiovascular disease
August 27, 2017 | rss feed
Biomedical engineering researchers will attack two banes of cardiovascular disease -; heart failure after heart attacks and the scourge of resistant high blood pressure -; with $4.8 million in National Institutes of Health grants that begin this... [read more]
UC San Diego researchers receive $18.2 million grant for B cell cancer clinical trial
August 27, 2017 | rss feed
The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine today unanimously approved an $18.29 million grant to University of California San Diego School of Medicine researchers to fund a phase Ib/IIa clinical... [read more]
Cover Image
August 26, 2017 | rss feed
Cover Art: Conditioned medium from hADSCs promote the migration and tube formation of HUVECs, neutralization of CXCL1 and CXCL8 in conditioned medium alleviate the facilitation of hADSCs. See Wang et al. beginning on page... [read more]
New research program receives DKK 100 million in funding from Novo Nordisk Foundation
August 25, 2017 | rss feed
The newly established research program, 'Program for Translational Hematology', has just received DKK 100 million in funding from the Novo Nordisk... [read more]
First FDA-approved stem cell trial for shoulder injuries reaches full enrollment
August 25, 2017 | rss feed
The trial is the first in the United States to offer an FDA-approved adipose-derived stem cell trial for shoulder... [read more]
Study may lead to new therapy options for treatment resistant, relapsed endometrial cancer
August 24, 2017 | rss feed
A team of Cleveland Clinic researchers have discovered a key pathway that leads to recurrence and treatment resistance in endometrial cancer, providing the potential for much needed new therapies for women with limited... [read more]
Bacterial infections may trigger dysregulation of blood formation
August 24, 2017 | rss feed
It has been thought that only immune cells would act as the line of defense during bacterial infection. However, recent research has revealed that hematopoietic stem cells, cells that create all other blood cells throughout an individual's lifetime,... [read more]
Scientists uncover stem cell response to prolonged irradiation
August 24, 2017 | rss feed
Researchers from several Russian institutes, including MIPT, have found out how prolonged exposure to ionizing radiation affects human stem... [read more]
USC scientist finds new approach to prevent HIV infection
August 23, 2017 | rss feed
Medical treatment that targets human proteins rather than ever-mutating viruses may one day help HIV-positive people whose bodies have built a resistance to "cocktails" currently used to keep them healthy, according to a Keck School of Medicine of USC... [read more]
Are stem cells the link between bacteria and cancer?
August 23, 2017 | rss feed
Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the... [read more]
Are stem cells the link between bacteria and cancer?
August 23, 2017 | rss feed
Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the... [read more]
Are stem cells the link between bacteria and cancer?
August 23, 2017 | rss feed
Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the... [read more]
Single Cell Phenotyping Reveals Heterogeneity Among Hematopoietic Stem Cells Following Infection
August 22, 2017 | rss feed
The hematopoietic stem cell (HSC) niche provides essential microenvironmental cues for the production and maintenance of HSCs within the bone marrow. During inflammation, hematopoietic dynamics are perturbed, but it is not known whether changes to the HSC–niche interaction occur as a result. We... [read more]
Researchers discover potential way to trigger regeneration, repair of damaged heart cells
August 21, 2017 | rss feed
New research has discovered a potential means to trigger damaged heart cells to self-heal. The discovery could lead to groundbreaking forms of treatment for heart... [read more]
The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation
August 21, 2017 | rss feed
Multipotent mesenchymal stem cells (MSCs) have enormous potential in tissue engineering and regenerative medicine. However, until now, their development for clinical use has been severely limited as they are a mixed population of cells with varying capacities for lineage differentiation and tissue... [read more]
Cyclin-Dependent Kinase 4 Regulates Adult Neural Stem Cell Proliferation and Differentiation in Response to Insulin
August 21, 2017 | rss feed
Insulin is one of the standard components used to culture primary neurospheres. Although it stimulates growth of different types of cells, the effects of insulin on adult neural stem cells (NSCs) have not been well characterized. Here, we reveal that insulin stimulates proliferation, but not... [read more]
New research suggests cell immortalization as more complicated process than originally thought
August 18, 2017 | rss feed
A mutation that helps make cells immortal is critical to the development of a tumor, but new research at the University of California, Berkeley suggests that becoming immortal is a more complicated process than originally... [read more]
Research identifies new gene fusions and mutations linked to GIST tumors
August 18, 2017 | rss feed
Researchers at UC San Diego Moores Cancer Center, with colleagues from Memorial Sloan Kettering Cancer Center and Fox Chase Cancer Center, have determined that a specific region of the small bowel, called the duodenal-jejunal flexure or DJF, shows a... [read more]
FDA approves Besponsa – Pfizer’s new drug for rare form of acute lymphoblastic leukemia
August 18, 2017 | rss feed
The U.S. Food and Drug Administration (FDA) today approved Besponsa (inotuzumab ozogamicin) in the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL) - a rare form of... [read more]
FDA approval provides new, targeted treatment option for adults with relapsed or refractory B-cell ALL
August 17, 2017 | rss feed
The U.S. Food and Drug Administration today approved Besponsa (inotuzumab ozogamicin) for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia... [read more]
Research provides clues to how infectious bacteria may increase risk of cancer
August 17, 2017 | rss feed
Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the... [read more]
Scientists discover novel lineage-restricted stem cell in the mammary gland
August 16, 2017 | rss feed
One of the key questions in stem cell and cancer biology is to understand the cellular hierarchy governing tissue development and maintenance and the cancer cell of... [read more]
Study offers novel insights into how genetic variants play key role in human immune system
August 16, 2017 | rss feed
It is widely recognized that people respond differently to infections. This can partially be explained by genetics, shows a new study published today in Nature Communications by an international collaboration of researchers from Germany and the United... [read more]
Cardiac stem cells from young hearts can make older hearts young, study says
August 16, 2017 | rss feed
A new study from the Cedars-Sinai Heart Institute, Los Angeles, published by the European Heart Journal, forecasts the use of infusions of cardiac stem cells obtained from young hearts in reversing the process of aging in the human... [read more]
Lab-grown miniature blood vessels mimic rare Hutchinson-Gilford Progeria Syndrome
August 16, 2017 | rss feed
Biomedical engineers have grown miniature human blood vessels that exhibit many of the symptoms and drug reactions associated with Hutchinson-Gilford Progeria Syndrome -- an extremely rare genetic disease that causes symptoms resembling accelerated... [read more]
How do broken bones heal?
August 15, 2017 | rss feed
Find out what gives our bones their remarkable ability to heal breaks in a finely tuned process that involves stem cells, cartilage, and bone.... [read more]
How do broken bones heal?
August 15, 2017 | rss feed
Find out what gives our bones their remarkable ability to heal breaks in a finely tuned process that involves stem cells, cartilage, and bone.... [read more]
Novel stem cell-derived model created of inflammatory neurological disorder
August 15, 2017 | rss feed
Brain-in-a-dish approach also showed two existing HIV drugs may be effective in rescuing mutated... [read more]
Novel stem cell-derived model created of inflammatory neurological disorder
August 15, 2017 | rss feed
Brain-in-a-dish approach also showed two existing HIV drugs may be effective in rescuing mutated... [read more]
Cardiac stem cell infusions could help reverse aging process in the heart, study shows
August 14, 2017 | rss feed
Cardiac stem cell infusions could someday help reverse the aging process in the human heart, making older ones behave younger, according to a new study from the Cedars-Sinai Heart... [read more]
Cardiac stem cell infusions could help reverse aging process in the heart, study shows
August 14, 2017 | rss feed
Cardiac stem cell infusions could someday help reverse the aging process in the human heart, making older ones behave younger, according to a new study from the Cedars-Sinai Heart... [read more]
Hair growth stimulated using stem cells
August 14, 2017 | rss feed
Using 3-D organoids made from stem cells, scientists managed to uncover a six-step process by which hair grows and stimulated hair growth.... [read more]
Hair growth stimulated using stem cells
August 14, 2017 | rss feed
Using 3-D organoids made from stem cells, scientists managed to uncover a six-step process by which hair grows and stimulated hair growth.... [read more]
Specialized stem cells may rejuvenate aged hearts
August 14, 2017 | rss feed
Injecting cardiosphere-derived cells from newborn rats into aged rats' hearts rejuvenated heart function, exercise capacity, and other markers of... [read more]
Specialized stem cells may rejuvenate aged hearts
August 14, 2017 | rss feed
Injecting cardiosphere-derived cells from newborn rats into aged rats' hearts rejuvenated heart function, exercise capacity, and other markers of... [read more]
Immunomodulatory Effects of Adipose Stromal Vascular Fraction Cells Promote Alternative Activation Macrophages to Repair Tissue Damage
August 12, 2017 | rss feed
The pathogenesis of many diseases is driven by the interactions between helper T (TH) cells and macrophages. The phenotypes of these cells are functional dichotomies that are persuaded according to the surrounding milieu. In both multiple sclerosis and the experimental autoimmune encephalomyelitis... [read more]
Immunomodulatory Effects of Adipose Stromal Vascular Fraction Cells Promote Alternative Activation Macrophages to Repair Tissue Damage
August 12, 2017 | rss feed
The pathogenesis of many diseases is driven by the interactions between helper T (TH) cells and macrophages. The phenotypes of these cells are a functional dichotomy that are persuaded according to the surrounding milieu. In both multiple sclerosis (MS) and the experimental autoimmune... [read more]
Immunomodulatory Effects of Adipose Stromal Vascular Fraction Cells Promote Alternative Activation Macrophages to Repair Tissue Damage
August 12, 2017 | rss feed
The pathogenesis of many diseases is driven by the interactions between helper T (TH) cells and macrophages. The phenotypes of these cells are a functional dichotomy that are persuaded according to the surrounding milieu. In both multiple sclerosis (MS) and the experimental autoimmune... [read more]