From 1908 when their existence was first hypothesized and the name “Stem Cell” was coined, it was then 70 years before definitive proof of their existence was shown in 1978. In the decades since then, research employing Stem Cells as treatments and therapies has exploded off the charts with research being conducted on nearly all the continents. The staff at StemCell101.com is dedicated to combing the internet, trade journals, and medical publications to bring consumers the latest information and news about this exciting and promising field.

stemcell-research 

The following are just some examples of the Worldwide Research Effort:

AFRICA

South Africa
In March 2012 scientists at South Africa’s Council for Scientific and Industrial Research (CSIR) set up a facility for biomedical stem cell technology. Its gene expression and biophysics group generated the first induced pluripotent stem cells (iPSCs) in Africa, the CSIR announced.

ASIA

China
China holds unrestrictive policies in regard to embryonic stem cell research – one of the most unrestrictive in the world. With this atmosphere Chinese scientists who have been educated and been trained in the West have flocked back to set up stem cell research laboratories in their home country. Stem cell researchers in the West attest to the fact that stem cell research facilities and researchers in China are already world class.

India
In Bangalore, India, the Institute for Stem Cell Biology and Regenerative Medicine (inStem) has state-of-the-art research facilities. Research at inStem includes stem cell biology, looking into mechanism that control differentiation and renewal, and impact of stem cells on recovery from stroke. Also in India, the Chaitanya Stem Cell Centre gives information on neurology, kidney, liver and many untreatable diseases. It also pushes regenerative medicine..

Japan
The following report is derived from the editorial. “New horizon in stem cell research,” of The Japan Times, February 3,2014 issue. Dr. Haruko Obokata and her team have found that body cells taken from mice can be reprogrammed into stem cells by exposing them to low-PH acid liquids. This new way of reprogramming adult cells into pluripotent cells (embryonic stem cells) is called “stimulus-triggered acquisition of pluripotency” or STAP. The STAP method is easier than that used by Dr. Shinya Yamanaka of Kyoto University, co-recipient with Sir John Gurdon of the Nobel Prize in Physiology or Medicine in 2012. In 2006 Yamanaka produced embryonic stem cells out of mouse skin by introducing four genes as growth factors. The cells are called induced pluripotent stem cells (iPSC). Yamanaka and his team did the same on human skin cells in 2007. STAP cells can form placenta which iPSC cannot do. “It is hoped that more efforts will be made so that the discovery will lead to the advancement of regenerative medicine.”

South Korea
The Stem Cell Research Center (SCRC) is a government-funded organization that supports stem cell research.The SCRC acts is a funding agency with 52 projects throughout South Korea. A national network, the Korean Society for Stem Cell Research, has been set up to facilitate stem cell research. The Stem Cell Research Center is the biggest stem cell center supported by Ministry of Science and Technology. Several other centers are supported by ministries like the Ministry of Health and Welfare. Several non-government organizations support stem cell research.

stemcellresearch-australiaAUSTRALIA

Some stem cell research trials being conducted in Australia include…..

[lists bullet=”square” type=”style1″]

  • Condition: Graft Versus Host Disease. Mesenchymal Stromal Cells for Acute Graft Versus Host Disease. The trial plans to enrol 66 patients by December 2015 and to be completed by December 2016.
  • Condition: Osteoarthritis. HiQCell Joint Registry in Patients with Osteoarthritis Following the HiQCell Procedure. The first patients underwent this procedure in July 2012.
  • Condition: Brain tumours. Gene Therapy and Chemotherapy for the Treatment of Childhood Brain Tumours. The trial commenced in July 2012.
  • Condition: Bone repair. Cranial Reconstruction Using Mesenchymal Stromal Cells and Resorbable Biomaterials. This trial is conducted at the Royal Perth Hospital in Western Australia from January 2013 to December 2015.
  • Condition: Leukaemia. Pilot Study of Partially Human Leucocyte Antigen-Mismatched Stem Cell Infusions after Chemotherapy for Acute Myeloid Leukaemia.
  • Condition: Osteoarthritis. The Osteoarthritis Stem Cell Advanced Research Study. This trial is conducted by the Rheumatology Department of the Royal North Shore Hospital St Leonards in New South Wales and Regeneus Pty Ltd. (Internet. March 10,2014)

[/lists]

EUROPE

Belgium
Belgian medical researchers succeeded in repairing bones using stem cells from fatty tissue.

The Saint Luc university clinic hospital in Brussels has a team that “has treated 11 patients, eight of them children, with fractures or bone defects that their bodies could not repair….” This was reported by the university on January 14, 2014. The breakthrough technique of Saint Luc’s centre for tissue and cellular therapy consists in removing a “sugar cube sized piece of fatty tissue from the patient, a less invasive process than pushing a needle into the pelvis and with a stem cell concentration they say is some 500 times higher.”

France
“The national assembly of France has voted to a lift a ban on embryonic stem cell research, which could pave the way for crucial scientific developments.” (France lifts its ban on embyonic stem cell reserch by Rebecca Taylor | Paris, France | LifeNews.com | 7/17/13)

I-Stem is the largest French laboratory for research and development devoted to embryonic origin obtained by reprogramming gene. It is a collaboration between Inserm – National Institute of Health and Medical Research – and AFM-Telethon – French Association against Myopathies.

Germany
Germany defines stem cell research as “the scientific study of embryonic, fetal, adult, as well as induced pluripotent stem cells of living organisms of all kinds. By definition, stem cells are cells that are not yet fully developed and therefore have the potential to differentiate into different cell types.” In the medical and biological fields findings in stem cell research are obtained and turned to benefit consumers. The ultimate goal is regenerating defective organs.

Spain
Spain has a comprehensive regulatory framework for stem cell research, consisting of laws and regulations on stem cell research. One partner in research is the Centre for Genomic Regulation. This is reported by “Regulation of stem cell research in Spain,” updated in August 2012.

United Kingdom
Stem cell researchers of the United Kingdom “fertilised (the) first animal and then human eggs outside the body; a discovery that led to the creation of embryos outside the body and the subsequent birth of the first ‘test-tube baby’ (in vitro fertilisation) in 1978.” (www.mrc-centre.cam.ac.uk)

A British researcher, Sir John Gurdon, opened the door for animal cloning with the reprogramming of frog egg nucleus. He is co-winner of Shinya Yamanaka of Nobel Prize in Medicine in 2012 for their stem cell research.

The UK had pioneered in setting up a stem cell bank. “Set up in 2002 and partly funded by the MRC, the bank reduces the requirement for surplus embryos for the development of stem cell lines by individual research groups” (Internet. March 10,2014).
Researchers will go into guided differentiation into desired adult cells like muscles of the heart.

The potential of stem cells in screening drugs will be looked into. This may reduce the need to go through animal testing.
The Research Councils and Technology Strategy Board have agreed to develop regenerative medicine.

NORTH AMERICA

Canada
In 1963, Canadian scientists James Till and Ernest McCulloch identified and named stem cells. Since then Canadians have been at the forefront of scientific research, according to CBC digital archives (Internet March 10,2014).

Dr. Andras Nagy and his colleagues at Toronto’s Mount Sinai Hospital developed a method of turning skin cell into stem cells.” The new reprogramming method replaces a process that until now was done using viruses and carried the risk of damaging cell DNA and causing cancer.”

Stem cell DNA are inserted into a skin cell and ”removed after the skin cell transforms into a stem cell.” The produced stem cells are safer; the use of embryonic stem cells is not needed. This was announced in 2009 (Internet. March 10, 2014)

United States

“US President Barack Obama has reversed some barriers to human embryonic stem cell research,” in March 2009. This reversed the ban by Pres. Bill Clinton in 1995 owing to the ethical controversy over the use of human embryonic stem cells, according to the editorial of the Nature Cell Biology in 2010. “On August 23, 2012, in a decision favorable to proponents of embryonic stem cell research, the U.S. Court of Appeals for the D.C. Circuit… (dismissed) a lawsuit that challenged the Obama administration’s expansion of federal funding for embryonic stem cell research” (Internet, March 10,2014).”…Much remains to be done to ensure that stem cell research flourishes in the US in the coming decades,” the editorial said.

With the advent of the use of induced pluripotent stem cells research in stem cell therapy has advanced. However, since this therapy is considered to fall under drugs by the Food and Drug Administration of the USA, it will take long before this therapy becomes available to US consumers.

stemcellresearch-central-americaCENTRAL AMERICA

Panama
The Stem Cell Institute “arose from the unmet need to provide stem cell therapies that have been shown by others to meet the bar of safety in Phase I trials, but are not yet widely available because efficacy has not been proven.” It was founded by Neil Riordan, Ph.D. who comes from an American biotechnology company. Since 2006 the Institute has treated over 1800 patients. Dr. Riordan is the inventor of a nutritional supplement for use in stem cell therapy – Stem-Kine. It increases the population of stem cells and endothelium progenitor cells (EPC) in the bone marrow. EPCs circulate the stem cells to home to damaged part of the body and promotes healing.

“We collaborate with doctors and scientists at major universities in the US, Canada, and Costa Rica; including the University of California, San Diego, University of Utah, University of Western Ontario, University of Florida, University of Massachusetts, and the University of Costa Rica. We are in the planning stages of performing clinical trials in collaboration with New York University and the University of Miami” according to the Stem Cell Institute (Internet. March 10,2014).

SOUTH AMERICA

Brazil
The Brazilian government has set up a national Review Board system to increase research activity and the prospect of treating chronic and degenerative diseases using cell therapy since 2010.

The Science and Technology Department of the Ministry of Health in collaboration with the National Research Council have funded more than 100 projects since 2005. Several groups constitute the Brazilian Cell Therapy Network to promote interaction among research laboratories. “Around US$50 million have been disbursed to the Network by the government between 2005 and 2010” (Internet. March 10,2014).

Global Stem Cell News

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Researchers use chemical array to find malignant cells within melanoma tumor
May 27, 2017 | rss feed
Melanoma is a particularly difficult cancer to treat once it has metastasized, spreading throughout the body. University of Illinois researchers are using chemistry to find the deadly, elusive malignant cells within a melanoma tumor that hold the... [read more]
Scientists discover receptor protein that promotes chronic heart failure
May 26, 2017 | rss feed
Researchers in Japan have identified a receptor protein on the surface of heart cells that promotes chronic heart... [read more]
Cover Image
May 26, 2017 | rss feed
Cover Art: Images of Control (left) and Cytochalasin D treatment (right). Cyto D treatment causes depolymerization of the actin cytoskeleton and transfer of actin monomers into the nucleus. See Sen et al. beginning on page... [read more]
Study finds two genetic variants linked to bicuspid aortic valve development
May 25, 2017 | rss feed
Researchers are working to determine why the aortic valve doesn't form correctly in patients with the most common congenital heart defect: bicuspid aortic... [read more]
Stem cell therapy using Helix transendocardial delivery system provides better results, study shows
May 25, 2017 | rss feed
BioCardia, Inc. today announced publication of a study in the International Heart Journal. According to the study, delivery of stem cell therapy to the heart using the Helix transendocardial delivery system results in superior cell delivery than... [read more]
FDA grants accelerated approval to cancer treatment based on common biomarker
May 24, 2017 | rss feed
The U.S. Food and Drug Administration today granted accelerated approval to a treatment for patients whose cancers have a specific genetic feature... [read more]
Study shows new promise in the fight against pancreatic cancer
May 23, 2017 | rss feed
New research from the Keck School of Medicine of the University of Southern California shows new promise in the fight against one of the most lethal forms of... [read more]
Researchers show how DPF2 protein controls blood cell production in leukemia
May 23, 2017 | rss feed
Many things go wrong in cells during the development of cancer. At the heart of the chaos are often genetic switches that control the production of new... [read more]
Researchers identify small RNA molecule that promotes deadly forms of breast cancer
May 23, 2017 | rss feed
Researchers from Princeton University's Department of Molecular Biology have identified a small RNA molecule that helps maintain the activity of stem cells in both healthy and cancerous breast... [read more]
Concise Review: Induced Pluripotent Stem Cell-Based Drug Discovery for Mitochondrial Disease
May 22, 2017 | rss feed
High attrition rates and loss of capital plague the drug discovery process. This is particularly evident for mitochondrial disease that typically involves neurological manifestations and is caused by nuclear or mitochondrial DNA defects. This group of heterogeneous disorders is difficult to target... [read more]
PRMT8 Controls the Pluripotency and Mesodermal Fate of Human Embryonic Stem Cells by Enhancing the PI3K/AKT/SOX2 axis
May 20, 2017 | rss feed
Basic fibroblast growth factor (bFGF) supplementation is critical to maintain the pluripotency of human pluripotent stem cells (hPSCs) through activation of PI3K/AKT, rather than MEK/ERK pathway. Thus, elaborate molecular mechanisms that preserve PI3K/AKT signaling upon bFGF stimulation may exist... [read more]
PRMT8 Controls the Pluripotency and Mesodermal Fate of Human Embryonic Stem Cells by Enhancing the PI3K/AKT/SOX2 axis
May 20, 2017 | rss feed
Basic fibroblast growth factor (bFGF) supplementation is critical to maintain the pluripotency of human pluripotent stem cells (hPSCs) through activation of PI3K/AKT, rather than MEK/ERK pathway. Thus, elaborate molecular mechanisms that preserve PI3K/AKT signaling upon bFGF stimulation may exist... [read more]
Injured bones reconstructed by gene and stem cell therapies
May 19, 2017 | rss feed
A Cedars-Sinai-led team of investigators has successfully repaired severe limb fractures in laboratory animals with an innovative technique that cues bone to regrow its own... [read more]
Researchers show how cancer therapy works in different way to destroy tumor cells
May 19, 2017 | rss feed
Antibodies to the proteins PD-1 and PD-L1 have been shown to fight cancer by unleashing the body's T cells, a type of immune... [read more]
Researchers discover innovative way to produce hematopoietic stem cells
May 18, 2017 | rss feed
A study published on May 17 in Nature, discovers an innovative method to produce infinite supply of healthy blood cells from the readily available cells that line blood vessels. This achievement by the researchers at Weill Cornell Medicine marks the... [read more]
Human iPSC-MSC-Derived Xenografts Modulate Immune Responses by Inhibiting the Cleavage of Caspases
May 18, 2017 | rss feed
Mesenchymal stem cells (MSCs) negatively modulate immune properties. Induced pluripotent stem cells (iPSCs)-derived MSCs are alternative source of MSCs. However, the effects of iPSC-MSCs on T cells phenotypes in vivo remain unclear. We established an iPSC-MSC-transplanted host versus graft reaction... [read more]
Researchers explore new treatment combination for pediatric patients with Hodgkin lymphoma
May 18, 2017 | rss feed
Pediatric and young adult patients whose Hodgkin lymphoma has recurred or is resistant to initial treatment can achieve remission and even cure with secondary... [read more]
Innovative technique could replace bone grafts to repair severe limb fractures
May 18, 2017 | rss feed
A Cedars-Sinai-led team of investigators has successfully repaired severe limb fractures in laboratory animals with an innovative technique that cues bone to regrow its own... [read more]
Human adipose-derived mesenchymal stem cell-secreted CXCL1 and CXCL8 facilitate breast tumor growth by promoting angiogenesis
May 17, 2017 | rss feed
Autologous adipose tissue or adipose tissue with additive adipose-derived mesenchymal stem cells (ADSCs) is used in the breast reconstruction of breast cancer patients who undergo mastectomy. ADSCs play an important role in the angiogenesis and adipogenesis, which make it much better than other... [read more]
‘Disease in a dish’ model pinpoints how defects in blood-brain barrier can cause psychomotor disorder
May 17, 2017 | rss feed
Scientists for the first time have assembled a "disease in a dish" model that pinpoints how a defect in the blood-brain barrier can produce an incurable psychomotor disorder, Allan-Herndon-Dudley... [read more]
Neurobiologists uncover reason for defects in the blood-brain barrier of Huntington’s disease patients
May 17, 2017 | rss feed
By using induced pluripotent stem cells to create endothelial cells that line blood vessels in the brain for the first time for a neurodegenerative disease, University of California, Irvine neurobiologists and colleagues have learned why Huntington's... [read more]
Scientists use AHDS patients’ cells to recreate disease and mimic blood-brain barrier
May 17, 2017 | rss feed
The blood-brain barrier is biology's proverbial double-edged sword. An impermeable shield of endothelial cells that protects our brains from toxins and other threats that may lurk in circulating blood, the barrier can also exclude therapeutic drugs... [read more]
Key stem cells for repairing knee joints identified
May 17, 2017 | rss feed
Stem cells that seem key for maintaining and repairing the body's knee joints have been identified by... [read more]
Scientists develop world’s first smartphone app to collect large data for people with MS
May 17, 2017 | rss feed
What if a single smartphone app could help solve the enigma of multiple sclerosis and move new treatments ahead at lightning speed? That was the bold idea that led Keck Medicine of USC neurologist Daniel Pelletier, MD, professor of neurology at the... [read more]
New lung ‘organoids’ in a dish mimic features of full-size lung
May 16, 2017 | rss feed
Mini organs' may aid in understanding, treating respiratory diseases.New lung "organoids" - tiny 3-D structures that mimic features of a full-sized lung - have been created from... [read more]
New clinical trial to evaluate efficacy of stem cell product in patients disabled with chronic stroke
May 16, 2017 | rss feed
A clinical trial to evaluate the safety and efficacy of a stem cell product injected directly into the brain to treat chronic motor deficits from ischemic stroke has begun at McGovern Medical School at The University of Texas Health Science Center at... [read more]
Stem cell treatment helps improve motor functions, nervous system conditions in mice with ALS
May 15, 2017 | rss feed
Researchers at the University of South Florida show in a new study that bone marrow stem cell transplants helped improve motor functions and nervous system conditions in mice with the disease Amyotrophic Lateral Sclerosis (ALS) by repairing damage to... [read more]
Scientists use new RNA sequencing and statistical techniques to track stem cells in the nose
May 12, 2017 | rss feed
Adult stem cells have the ability to transform into many types of cells, but tracing the path individual stem cells follow as they mature and identifying the molecules that trigger these fateful decisions are difficult in a living... [read more]
New organoid ‘fusion’ technique helps observe complex interactions between diverse brain regions
May 11, 2017 | rss feed
In 2013 researchers led by IMBA scientist Jürgen Knoblich flabbergasted the scientific community. Starting from human stem cells, researchers in his lab managed to grow living three dimensional models of basic units of human brain in a... [read more]
CNIO researchers optimize new system capable of generating cellular model of Ewing sarcoma
May 10, 2017 | rss feed
A team from the Spanish National Cancer Research Centre (CNIO) has optimized a system capable of generating a cellular model of Ewing... [read more]
UC researchers find stem cell vaccine to enhance immune responses against tumors in animal models
May 10, 2017 | rss feed
Researchers at the University of Cincinnati have found that a cancer stem cell vaccine, engineered to express a pro-inflammatory protein called interleukin-15 (IL-15) and its receptor (IL-15Ralpha), caused T cell production in animal models and... [read more]
With stem cells to new intervertebral discs
May 10, 2017 | rss feed
It is the "shock absorber" between the vertebrae of the spine, cushioning every step, bend and jump: the intervertebral... [read more]
Researchers discover that microRNA can prevent excessive intestinal inflammation
May 9, 2017 | rss feed
An international team of researchers has discovered that a microRNA produced by certain white blood cells can prevent excessive inflammation in the... [read more]
Study findings could help identify treatments for balding and hair graying
May 9, 2017 | rss feed
Researchers at the UT Southwestern Medical Center have discovered the cells that are directly responsible for hair growth and the mechanism that causes gray hair. The study results could help in identifying feasible treatments for balding and hair... [read more]
Treatment with the body’s own stem cells may help form new intervertebral disc cartilage
May 9, 2017 | rss feed
It is the "shock absorber" between the vertebrae of the spine, cushioning every step, bend and jump: the intervertebral disc. If the fibrocartilage tissue in the spine degenerates over time, an intervertebral disc can "slip" - pinching the medulla or... [read more]
UAB symposium highlights use of tissue engineering to repair broken hearts
May 9, 2017 | rss feed
The third annual Cardiovascular Tissue Engineering Symposium met at the University of Alabama at Birmingham last month, a gathering of noted physicians and scientists who share the goal of creating new tissues and new knowledge that can prevent or... [read more]
UVA research finding sheds light on cause of deadly heart condition
May 9, 2017 | rss feed
Kidney research at the University of Virginia School of Medicine has unexpectedly led to a discovery about the formation of the heart, including the identification of a gene responsible for a deadly cardiac... [read more]
UT Southwestern researchers uncover mechanism linked to balding and hair graying
May 9, 2017 | rss feed
UT Southwestern Medical Center researchers have identified the cells that directly give rise to hair as well as the mechanism that causes hair to turn gray - findings that could one day help identify possible treatments for balding and hair... [read more]
Adiponectin Enhances Quiescence Exit of Murine Hematopoietic Stem Cells and Hematopoietic Recovery Through mTORC1 Potentiation
May 8, 2017 | rss feed
Myelotoxic injury, such as chemotherapeutic agents and ionizing radiation, unlocks the vigorous power of hematopoietic stem cells (HSCs) to replenish the hematopoietic system, making quiescent HSCs enter the cell cycle. Considering that both HSC-intrinsic and -extrinsic mechanisms enforce... [read more]
Cell Therapy in Parkinson’s Disease: Host Brain Repair Machinery Gets a Boost From Stem Cell Grafts
May 8, 2017 | rss feed
This commentary highlights the major findings and future research directions arising from the recent publication by Zuo and colleagues in Stem Cells 2017 (in press). Here, we discuss the novel observations that transplanted human neural stem cells can induce endogenous brain repair by specifically... [read more]
The Endothelial Protein C Receptor is a Potential Stem Cell Marker for Epidermal Keratinocytes
May 8, 2017 | rss feed
Endothelial protein C receptor (EPCR) is a specific receptor for anticoagulant protein C and expressed by human epidermis and cultured keratinocytes. Here we investigated whether: (a) the level of EPCR in keratinocytes is associated with their growth potential; and (b) EPCR is a potential marker... [read more]
Slow-Myofiber Commitment by Semaphorin 3A Secreted from Myogenic Stem Cells
May 8, 2017 | rss feed
Recently, we found that resident myogenic stem satellite cells up-regulate a multi-functional secreted protein, semaphorin 3A (Sema3A), exclusively at the early- differentiation phase in response to muscle injury; however, its physiological significance is still unknown. Here we show that Sema3A... [read more]
Vitamin A deficiency leads to loss of blood stem cells
May 6, 2017 | rss feed
Many specialized cells, such as in the skin, gut or blood, have a lifespan of only a few days. Therefore, steady replenishment of these cells is indispensable. They arise from so-called "adult" stem cells that divide... [read more]
GW scientist awarded $1.7 million grant to understand mechanisms behind Hedgehog receptor
May 5, 2017 | rss feed
Among scientists specializing in the area, the mechanisms behind the signaling function of the Hedgehog (Hh) receptor pathway remain a mystery. Xiaoyen Zheng, Ph.D., assistant professor of anatomy and regenerative biology at the George Washington... [read more]
Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q10 Deficiency
May 4, 2017 | rss feed
Coenzyme Q10 (CoQ10) plays a crucial role in mitochondria as an electron carrier within the mitochondrial respiratory chain (MRC) and is an essential antioxidant. Mutations in genes responsible for CoQ10 biosynthesis (COQ genes) cause primary CoQ10 deficiency, a rare and heterogeneous mitochondrial... [read more]
Genetic rescue of Mitochondrial and Skeletal Muscle Impairment in an IPSCs Model of Coenzyme Q10 Deficiency
May 4, 2017 | rss feed
Coenzyme Q10 (CoQ10) plays a crucial role in mitochondria as an electron carrier within the mitochondrial respiratory chain (MRC), and is an essential antioxidant. Mutations in genes responsible for CoQ10 biosynthesis (COQ genes) cause primary CoQ10 deficiency, a rare and heterogeneous... [read more]
CD36 Is a Marker of Human Adipocyte Progenitors with Pronounced Adipogenic and Triglyceride Accumulation Potential
May 4, 2017 | rss feed
White adipose tissue (WAT) expands in part through adipogenesis, a process involving fat cell generation and fatty acid (FA) storage into triglycerides (TGs). Several findings suggest that inter-individual and regional variations in adipogenesis are linked to metabolic complications. We aimed to... [read more]
Parkinson’s in a dish: Researchers reproduce brain oscillations
May 4, 2017 | rss feed
Abnormal oscillations in neurons that control movement, which likely cause the tremors that characterize Parkinson's disease, have long been reported in patients with the... [read more]
Parkinson’s in a dish: Researchers reproduce brain oscillations
May 4, 2017 | rss feed
Abnormal oscillations in neurons that control movement, which likely cause the tremors that characterize Parkinson's disease, have long been reported in patients with the... [read more]
New study uses 10x Genomics’ Single Cell 3’ Solution to unravel stem cell self-renewal mechanism
May 4, 2017 | rss feed
10x Genomics, a company focused on enabling the mastery of biology by accelerating genomic discovery, today announced publication of an article in the journal Nature of a collaborative research study with researchers at the Stanford University School... [read more]
Scientists grow and purify earliest lung progenitors from human stem cells
May 3, 2017 | rss feed
Human lungs, like all organs, begin their existence as clumps of undifferentiated stem cells. But in a matter of months, the cells get organized. They gather together, branch and bud, some forming airways and others alveoli, the delicate sacs where... [read more]
ARVO 2017 to showcase latest advances in treatments for eye disease and blindness
May 3, 2017 | rss feed
The Annual Meeting of the Association for Research in Vision and Ophthalmology is the largest gathering of eye and vision researchers in the world, with over 11,000 attendees from more than 75... [read more]
Study shows thinning of gray matter in the brains of patients with bipolar disorder
May 2, 2017 | rss feed
A new study has found brain abnormalities in people with bipolar disorder. In the largest MRI study to date on patients with bipolar disorder, a global consortium published new research showing that people with the condition have differences in the... [read more]
Combination therapy may be effective option for treating some women with ovarian cancer
May 2, 2017 | rss feed
Researchers have been trying to understand why up to 85 percent of women experience recurrence of high-grade serous ovarian cancer -- the most common subtype of ovarian cancer -- after standard treatment with the chemotherapy drug... [read more]
Study signals need to screen genes for stem cell transplants
May 2, 2017 | rss feed
Regenerative medicine using human pluripotent stem cells to grow transplantable tissue outside the body carries the promise to treat a range of intractable disorders, such as diabetes... [read more]
New study shows that gene editing technology can shut down HIV-1 replication in animals
May 2, 2017 | rss feed
A permanent cure for HIV infection remains elusive due to the virus's ability to hide away in latent reservoirs. But now, in new research published in print May 3 in the journal Molecular Therapy, scientists at the Lewis Katz School of Medicine at... [read more]
Stem cells edited to fight arthritis
May 1, 2017 | rss feed
Using new gene-editing technology, researchers have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic... [read more]
Stem cells edited to fight arthritis
May 1, 2017 | rss feed
Using new gene-editing technology, researchers have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic... [read more]
Scientists launch new virtual platform to aid global search for treatment of leukemia
April 29, 2017 | rss feed
Finding a cure for a rare type of blood cancer could be accelerated by a new virtual platform that allows researchers easy access to data from patient samples generated by laboratories around the... [read more]
Gene critical for tumor growth also encourages growth of intestinal stem cells, study shows
April 28, 2017 | rss feed
A gene previously identified as critical for tumor growth in many human cancers also maintains intestinal stem cells and encourages the growth of cells that support them, according to results of a study led by Johns Hopkins... [read more]
Researchers succeed in generating 3D bioprinted cartilage tissue
April 28, 2017 | rss feed
A team of researchers at Sahlgrenska Academy has managed to generate cartilage tissue by printing stem cells using a... [read more]
New insights on triggering muscle formation
April 28, 2017 | rss feed
Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a previously unrecognized step in stem cell-mediated muscle... [read more]
Scientists rewire mouse stem cells to fight inflammation caused by arthritis
April 28, 2017 | rss feed
Using new gene-editing technology, researchers have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic... [read more]
Growing mouse tooth provides new understanding of tissue renewal processes
April 28, 2017 | rss feed
Researchers hope to one day use stem cells to heal burns, patch damaged heart tissue, even grow kidneys and other transplantable organs from... [read more]
NETRF announces $4 million in collaborative grants to study neuroendocrine tumors
April 28, 2017 | rss feed
The Neuroendocrine Tumor Research Foundation today announced its largest research commitment ever -- $4 million in collaborative grants -- most from its new Accelerator Grants program to study neuroendocrine tumors, a widely misunderstood, commonly... [read more]
Study underscores need for genetic screening to improve safety of experimental stem cell treatments
April 27, 2017 | rss feed
Regenerative medicine using human pluripotent stem cells to grow transplantable tissue outside the body carries the promise to treat a range of intractable disorders, such as diabetes and Parkinson's... [read more]
Study provides new insights on molecular mechanisms that impair muscle stem cells during aging
April 26, 2017 | rss feed
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a previously unrecognized step in stem cell-mediated muscle... [read more]
New chlamydia drug targets discovered using CRISPR and stem cells
April 26, 2017 | rss feed
Scientists at the Wellcome Trust Sanger Institute and their collaborators at the University of British Columbia have created an innovative technique for studying how chlamydia interacts with... [read more]
Discovery offers new hope to repair spinal cord injuries
April 26, 2017 | rss feed
Scientists at the Gladstone Institutes created a special type of neuron from human stem cells that could potentially repair spinal cord... [read more]
Scientists create new technique for studying how chlamydia interacts with immune system
April 25, 2017 | rss feed
Scientists at the Wellcome Trust Sanger Institute and their collaborators at the University of British Columbia have created an innovative technique for studying how chlamydia interacts with the human immune... [read more]
Scientists use stem cells to identify underlying cellular defects that cause Angelman syndrome
April 25, 2017 | rss feed
Researchers at UConn Health used stem cells derived from patients with Angelman syndrome to identify the underlying cellular defects that cause the rare neurogenetic disorder, an important step in the ongoing search for potential treatments for... [read more]
Cover Image
April 25, 2017 | rss feed
Cover Art: Low dose radiation causes basal cell carcinoma (BCC) with full penetrance in Ptch1 heterozygous mice. Image shows BCC in the back skin of an epidermis-specific Ptch1 heterozygous mouse 1 year after receiving 50 mGy irradiation. See Revenco... [read more]
Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells
April 24, 2017 | rss feed
ERG, an ETS family transcription factor frequently overexpressed in human leukemia, has been implicated as a key regulator of hematopoietic stem cells. However, how ERG controls normal hematopoiesis, particularly at the stem and progenitor cell level, and how it contributes to leukemogenesis remain... [read more]
Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2-Mediated Degradation of p53
April 24, 2017 | rss feed
Bre is a conserved cellular protein expressed in various tissues. Its major function includes DNA damage repair and anti-apoptosis. Recent studies indicate that Bre is potentially involved in stem cell differentiation although pathophysiological significance along with the molecular mechanisms is... [read more]
Unacylated Ghrelin Enhances Satellite Cell Function and Relieves the Dystrophic Phenotype in Duchenne Muscular Dystrophy mdx Model
April 24, 2017 | rss feed
Muscle regeneration depends on satellite cells (SCs), quiescent precursors that, in consequence of injury or in pathological states such as muscular dystrophies, activate, proliferate, and differentiate to repair the damaged tissue. A subset of SCs undergoes self-renewal, thus preserving the SC... [read more]
Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2
April 24, 2017 | rss feed
HIV-1 Tat-interacting protein of 110 kDa, Tip110, plays important roles in multiple biological processes. In this study, we aimed to characterize the function of Tip110 in embryonic development. Transgenic mice lacking expression of a functional Tip110 gene (Tip110–/–) died post-implantation,... [read more]
UCLA research overturns paradigm about how axons grow during embryonic development
April 21, 2017 | rss feed
New research by scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA overturns a long-standing paradigm about how axons -- thread-like projections that connect cells in the nervous system -- grow during... [read more]
Researchers develop new approach to protect stem cell recipients from graft-versus-host disease
April 21, 2017 | rss feed
Stem cell transplants can save lives, for example in patients with leukemia. However, these treatments are not free of risks. One complication that may occur is graft-versus-host disease (GVHD), basically donor-derived immune cells attacking the recipient’s... [read more]
Research shows potential way to limit damage to the brain caused by seizure disorder
April 21, 2017 | rss feed
Tiny vesicles isolated from adult mesenchymal stem cells and administered intranasally can limit the damage to the brain of animal models caused by a seizure disorder called status epilepticus, according to research published this week in the... [read more]
New model may provide vital insights into life-saving treatment for CMV infection
April 21, 2017 | rss feed
At-risk patients, such as those with HIV or transplant recipients, could benefit from potentially life-saving study carried out by a University of Surrey led group of international... [read more]
Protein primes mouse stem cells to quickly repair injury, Stanford study finds
April 20, 2017 | rss feed
Like drag car racers revving their engines at the starting line, stem cells respond more quickly to injury when they've been previously primed with one dose of a single protein, according to... [read more]
Penn researchers pinpoint underlying cause of Best disease
April 20, 2017 | rss feed
Named for Friedrich Best, who characterized the disease in 1905, Best disease, also known as vitelliform macular dystrophy, affects children and young adults and can cause severe declines in central vision as patients... [read more]
Researchers develop ultrasensitive method to detect protein involved in autoimmune diseases
April 19, 2017 | rss feed
Researchers in France have developed a new method that will allow doctors to detect minute amounts of a protein called interferon-a in patient... [read more]
Researchers find new way to prevent graft-versus-host disease after stem cell transplants
April 18, 2017 | rss feed
Through experimental work, an international team of researchers led by City of Hope's Defu Zeng, professor of diabetes immunology and hematopoietic cell transplantation, believe they may have found a way to prevent graft-versus-host disease after stem... [read more]
MIT researchers develop new technique to make high-resolution images of tissues
April 18, 2017 | rss feed
MIT researchers have developed a way to make extremely high-resolution images of tissue samples, at a fraction of the cost of other techniques that offer similar... [read more]
Cell cultures in petri dishes open new doors to brain research
April 14, 2017 | rss feed
The most complex organ in humans is the brain. Due to its complexity and, of course, for ethical reasons, it is extremely difficult to do scientific experiments on it - ones that could help us to understand neurodegenerative diseases like Parkinson's,... [read more]
Researchers correct Duchenne muscular dystrophy using gene-editing alternative
April 13, 2017 | rss feed
Using the new gene-editing enzyme CRISPR-Cpf1, researchers at UT Southwestern Medical Center have successfully corrected Duchenne muscular dystrophy in human cells and mice in the... [read more]
New approach makes cells resistant to HIV
April 13, 2017 | rss feed
Scientists at The Scripps Research Institute (TSRI) have found a way to tether HIV-fighting antibodies to immune cells, creating a cell population resistant to the... [read more]
Brief Report: Robo1 Regulates the Migration of Human Subventricular Zone Neural Progenitor Cells during Development
April 13, 2017 | rss feed
Human neural progenitor cell (NPC) migration within the subventricular zone (SVZ) of the lateral ganglionic eminence is an active process throughout early brain development. The migration of human NPCs from the SVZ to the olfactory bulb during fetal stages resembles what occurs in adult rodents. As... [read more]
TSRI scientists find new way to make cell population resistant to HIV
April 12, 2017 | rss feed
Scientists at The Scripps Research Institute have found a way to tether HIV-fighting antibodies to immune cells, creating a cell population resistant to the... [read more]
Researchers uncover mechanism that leads to disorders in pancreatic development, infant diabetes
April 12, 2017 | rss feed
Researchers at the University of Helsinki, Finland, have uncovered a mechanism through which a mutation in the STAT3 gene leads to a disorder in the development of the pancreas and to infant... [read more]
New nanowire technology may serve as platform to screen drugs for neurological diseases
April 12, 2017 | rss feed
A team led by engineers at the University of California San Diego has developed nanowires that can record the electrical activity of neurons in fine... [read more]
Alpha-Ketoglutarate Curbs Differentiation and Induces Cell Death in Mesenchymal Stromal Precursors with Mitochondrial Dysfunction
April 11, 2017 | rss feed
Increased concentrations of reactive oxygen species (ROS) originating from dysfunctional mitochondria contribute to diverse aging-related degenerative disorders. But so far little is known about the impact of distinct ROS on metabolism and fate of stromal precursor cells. Here, we demonstrate that... [read more]
Peptide acts as mediator for learning
April 11, 2017 | rss feed
The ability of the brain to respond and adapt to changes is scientifically called brain plasticity. This ability is the basis of all learning... [read more]