From 1908 when their existence was first hypothesized and the name “Stem Cell” was coined, it was then 70 years before definitive proof of their existence was shown in 1978. In the decades since then, research employing Stem Cells as treatments and therapies has exploded off the charts with research being conducted on nearly all the continents. The staff at StemCell101.com is dedicated to combing the internet, trade journals, and medical publications to bring consumers the latest information and news about this exciting and promising field.

stemcell-research 

The following are just some examples of the Worldwide Research Effort:

AFRICA

South Africa
In March 2012 scientists at South Africa’s Council for Scientific and Industrial Research (CSIR) set up a facility for biomedical stem cell technology. Its gene expression and biophysics group generated the first induced pluripotent stem cells (iPSCs) in Africa, the CSIR announced.

ASIA

China
China holds unrestrictive policies in regard to embryonic stem cell research – one of the most unrestrictive in the world. With this atmosphere Chinese scientists who have been educated and been trained in the West have flocked back to set up stem cell research laboratories in their home country. Stem cell researchers in the West attest to the fact that stem cell research facilities and researchers in China are already world class.

India
In Bangalore, India, the Institute for Stem Cell Biology and Regenerative Medicine (inStem) has state-of-the-art research facilities. Research at inStem includes stem cell biology, looking into mechanism that control differentiation and renewal, and impact of stem cells on recovery from stroke. Also in India, the Chaitanya Stem Cell Centre gives information on neurology, kidney, liver and many untreatable diseases. It also pushes regenerative medicine..

Japan
The following report is derived from the editorial. “New horizon in stem cell research,” of The Japan Times, February 3,2014 issue. Dr. Haruko Obokata and her team have found that body cells taken from mice can be reprogrammed into stem cells by exposing them to low-PH acid liquids. This new way of reprogramming adult cells into pluripotent cells (embryonic stem cells) is called “stimulus-triggered acquisition of pluripotency” or STAP. The STAP method is easier than that used by Dr. Shinya Yamanaka of Kyoto University, co-recipient with Sir John Gurdon of the Nobel Prize in Physiology or Medicine in 2012. In 2006 Yamanaka produced embryonic stem cells out of mouse skin by introducing four genes as growth factors. The cells are called induced pluripotent stem cells (iPSC). Yamanaka and his team did the same on human skin cells in 2007. STAP cells can form placenta which iPSC cannot do. “It is hoped that more efforts will be made so that the discovery will lead to the advancement of regenerative medicine.”

South Korea
The Stem Cell Research Center (SCRC) is a government-funded organization that supports stem cell research.The SCRC acts is a funding agency with 52 projects throughout South Korea. A national network, the Korean Society for Stem Cell Research, has been set up to facilitate stem cell research. The Stem Cell Research Center is the biggest stem cell center supported by Ministry of Science and Technology. Several other centers are supported by ministries like the Ministry of Health and Welfare. Several non-government organizations support stem cell research.

stemcellresearch-australiaAUSTRALIA

Some stem cell research trials being conducted in Australia include…..

[lists bullet=”square” type=”style1″]

  • Condition: Graft Versus Host Disease. Mesenchymal Stromal Cells for Acute Graft Versus Host Disease. The trial plans to enrol 66 patients by December 2015 and to be completed by December 2016.
  • Condition: Osteoarthritis. HiQCell Joint Registry in Patients with Osteoarthritis Following the HiQCell Procedure. The first patients underwent this procedure in July 2012.
  • Condition: Brain tumours. Gene Therapy and Chemotherapy for the Treatment of Childhood Brain Tumours. The trial commenced in July 2012.
  • Condition: Bone repair. Cranial Reconstruction Using Mesenchymal Stromal Cells and Resorbable Biomaterials. This trial is conducted at the Royal Perth Hospital in Western Australia from January 2013 to December 2015.
  • Condition: Leukaemia. Pilot Study of Partially Human Leucocyte Antigen-Mismatched Stem Cell Infusions after Chemotherapy for Acute Myeloid Leukaemia.
  • Condition: Osteoarthritis. The Osteoarthritis Stem Cell Advanced Research Study. This trial is conducted by the Rheumatology Department of the Royal North Shore Hospital St Leonards in New South Wales and Regeneus Pty Ltd. (Internet. March 10,2014)

[/lists]

EUROPE

Belgium
Belgian medical researchers succeeded in repairing bones using stem cells from fatty tissue.

The Saint Luc university clinic hospital in Brussels has a team that “has treated 11 patients, eight of them children, with fractures or bone defects that their bodies could not repair….” This was reported by the university on January 14, 2014. The breakthrough technique of Saint Luc’s centre for tissue and cellular therapy consists in removing a “sugar cube sized piece of fatty tissue from the patient, a less invasive process than pushing a needle into the pelvis and with a stem cell concentration they say is some 500 times higher.”

France
“The national assembly of France has voted to a lift a ban on embryonic stem cell research, which could pave the way for crucial scientific developments.” (France lifts its ban on embyonic stem cell reserch by Rebecca Taylor | Paris, France | LifeNews.com | 7/17/13)

I-Stem is the largest French laboratory for research and development devoted to embryonic origin obtained by reprogramming gene. It is a collaboration between Inserm – National Institute of Health and Medical Research – and AFM-Telethon – French Association against Myopathies.

Germany
Germany defines stem cell research as “the scientific study of embryonic, fetal, adult, as well as induced pluripotent stem cells of living organisms of all kinds. By definition, stem cells are cells that are not yet fully developed and therefore have the potential to differentiate into different cell types.” In the medical and biological fields findings in stem cell research are obtained and turned to benefit consumers. The ultimate goal is regenerating defective organs.

Spain
Spain has a comprehensive regulatory framework for stem cell research, consisting of laws and regulations on stem cell research. One partner in research is the Centre for Genomic Regulation. This is reported by “Regulation of stem cell research in Spain,” updated in August 2012.

United Kingdom
Stem cell researchers of the United Kingdom “fertilised (the) first animal and then human eggs outside the body; a discovery that led to the creation of embryos outside the body and the subsequent birth of the first ‘test-tube baby’ (in vitro fertilisation) in 1978.” (www.mrc-centre.cam.ac.uk)

A British researcher, Sir John Gurdon, opened the door for animal cloning with the reprogramming of frog egg nucleus. He is co-winner of Shinya Yamanaka of Nobel Prize in Medicine in 2012 for their stem cell research.

The UK had pioneered in setting up a stem cell bank. “Set up in 2002 and partly funded by the MRC, the bank reduces the requirement for surplus embryos for the development of stem cell lines by individual research groups” (Internet. March 10,2014).
Researchers will go into guided differentiation into desired adult cells like muscles of the heart.

The potential of stem cells in screening drugs will be looked into. This may reduce the need to go through animal testing.
The Research Councils and Technology Strategy Board have agreed to develop regenerative medicine.

NORTH AMERICA

Canada
In 1963, Canadian scientists James Till and Ernest McCulloch identified and named stem cells. Since then Canadians have been at the forefront of scientific research, according to CBC digital archives (Internet March 10,2014).

Dr. Andras Nagy and his colleagues at Toronto’s Mount Sinai Hospital developed a method of turning skin cell into stem cells.” The new reprogramming method replaces a process that until now was done using viruses and carried the risk of damaging cell DNA and causing cancer.”

Stem cell DNA are inserted into a skin cell and ”removed after the skin cell transforms into a stem cell.” The produced stem cells are safer; the use of embryonic stem cells is not needed. This was announced in 2009 (Internet. March 10, 2014)

United States

“US President Barack Obama has reversed some barriers to human embryonic stem cell research,” in March 2009. This reversed the ban by Pres. Bill Clinton in 1995 owing to the ethical controversy over the use of human embryonic stem cells, according to the editorial of the Nature Cell Biology in 2010. “On August 23, 2012, in a decision favorable to proponents of embryonic stem cell research, the U.S. Court of Appeals for the D.C. Circuit… (dismissed) a lawsuit that challenged the Obama administration’s expansion of federal funding for embryonic stem cell research” (Internet, March 10,2014).”…Much remains to be done to ensure that stem cell research flourishes in the US in the coming decades,” the editorial said.

With the advent of the use of induced pluripotent stem cells research in stem cell therapy has advanced. However, since this therapy is considered to fall under drugs by the Food and Drug Administration of the USA, it will take long before this therapy becomes available to US consumers.

stemcellresearch-central-americaCENTRAL AMERICA

Panama
The Stem Cell Institute “arose from the unmet need to provide stem cell therapies that have been shown by others to meet the bar of safety in Phase I trials, but are not yet widely available because efficacy has not been proven.” It was founded by Neil Riordan, Ph.D. who comes from an American biotechnology company. Since 2006 the Institute has treated over 1800 patients. Dr. Riordan is the inventor of a nutritional supplement for use in stem cell therapy – Stem-Kine. It increases the population of stem cells and endothelium progenitor cells (EPC) in the bone marrow. EPCs circulate the stem cells to home to damaged part of the body and promotes healing.

“We collaborate with doctors and scientists at major universities in the US, Canada, and Costa Rica; including the University of California, San Diego, University of Utah, University of Western Ontario, University of Florida, University of Massachusetts, and the University of Costa Rica. We are in the planning stages of performing clinical trials in collaboration with New York University and the University of Miami” according to the Stem Cell Institute (Internet. March 10,2014).

SOUTH AMERICA

Brazil
The Brazilian government has set up a national Review Board system to increase research activity and the prospect of treating chronic and degenerative diseases using cell therapy since 2010.

The Science and Technology Department of the Ministry of Health in collaboration with the National Research Council have funded more than 100 projects since 2005. Several groups constitute the Brazilian Cell Therapy Network to promote interaction among research laboratories. “Around US$50 million have been disbursed to the Network by the government between 2005 and 2010” (Internet. March 10,2014).

Global Stem Cell News

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Could stem cells reverse the aging process?
July 28, 2017 | rss feed
Stem cells found in the hypothalamus are responsible for the aging process, new research shows. Supplementary stem cells might reverse aging,... [read more]
Gene editing technology shines light on rare dyskeratosis congenita
July 27, 2017 | rss feed
Using the gene editing technology CRISPR, scientists have shed light on a rare, sometimes fatal syndrome that causes children to gradually lose the ability to manufacture vital blood... [read more]
Heart attack: Blood vessel growth may improve treatment
July 27, 2017 | rss feed
The discovery of how a signaling pathway and the hormone leptin stimulate new blood vessel growth could help to improve cancer and heart attack treatment.... [read more]
Research shows key role of diffusion dynamics in stem cell differentiation and tissue development
July 27, 2017 | rss feed
Gradients of molecular signaling factors play an essential role in numerous events in embryonic development, from patterning limb and organ formation to the intricate shaping of the brain and neuroanatomical... [read more]
Stem cell-based method selectively targets cancerous tissue while preventing toxic side effects
July 27, 2017 | rss feed
A stem cell-based method created by University of California, Irvine scientists can selectively target and kill cancerous tissue while preventing some of the toxic side effects of chemotherapy by treating the disease in a more localized... [read more]
Cover Image
July 27, 2017 | rss feed
Cover Art: Mesenchymal stem cells (MSCs) enhance autophagymediated α-synuclein clearance via microtubule (MT)- dependent trafficking. Electron microscopy analysis showing autophagic vacuoles in α-synuclein-WT cells (first image) or... [read more]
Concise Review: Stem Cells for Corneal Wound Healing
July 27, 2017 | rss feed
Corneal wound healing is a complex process that occurs in response to various injuries and commonly used refractive surgery. It is a significant clinical problem, which may lead to serious complications due to either incomplete (epithelial) or excessive (stromal) healing. Epithelial stem cells... [read more]
Concise Review: Stem Cells for Corneal Wound Healing
July 27, 2017 | rss feed
Corneal wound healing is a complex process that occurs in response to various injuries and commonly used refractive surgery. It is a significant clinical problem, which may lead to serious complications due to either incomplete (epithelial) or excessive (stromal) healing. Epithelial stem cells... [read more]
Anti-cancer chemotherapeutic agent inhibits glioblastoma growth and radiation resistance
July 26, 2017 | rss feed
Glioblastoma is a primary brain tumor with dismal survival rates, even after treatment with surgery, chemotherapy and... [read more]
Neuro-oncology scientists discover unique molecular mechanism that maintains glioma stem cells
July 25, 2017 | rss feed
Glioblastoma is a primary brain tumor with dismal survival rates, even after treatment with surgery, chemotherapy, and... [read more]
In vivo rescue of the hematopoietic niche by pluripotent stem cell complementation of defective osteoblast compartments
July 25, 2017 | rss feed
Bone-forming osteoblasts play critical roles in supporting bone marrow hematopoiesis. Pluripotent stem cells (PSCs), including embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, are capable of differentiating into osteoblasts. To determine the capacity of stem cells needed to... [read more]
New map may be first step to developing treatments for complex brain disorders
July 25, 2017 | rss feed
Just as parents are not the root of all their children's problems, a single gene mutation can't be blamed for complex brain disorders like autism, according to a Keck School of Medicine of USC... [read more]
Stem cell centers claim to offer effective heart failure therapy despite lack of FDA approval
July 25, 2017 | rss feed
Stem cell centers claim to offer effective treatment to patients with heart failure, despite the fact that the treatment is not approved for such use by the U.S. Food and Drug Administration, says the author of research letter in the current issue of... [read more]
Quiescent Oct4+ Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein+ NSCs in the Adult Mouse Brain
July 22, 2017 | rss feed
Adult primitive neural stem cells (pNSCs) are a rare population of glial fibrillary acidic protein (GFAP)– Oct4+ cells in the mouse forebrain subependymal zone bordering the lateral ventricles that give rise to clonal neurospheres in leukemia inhibitory factor in vitro. pNSC neurospheres can be... [read more]
Quiescent Oct4+ Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein+ NSCs in the Adult Mouse Brain
July 22, 2017 | rss feed
Adult primitive neural stem cells (pNSCs) are a rare population of glial fibrillary acidic protein (GFAP)– Oct4+ cells in the mouse forebrain subependymal zone bordering the lateral ventricles that give rise to clonal neurospheres in leukemia inhibitory factor in vitro. pNSC neurospheres can be... [read more]
Testing treatments using pig model may help minimize drug failure rates for chronic conditions
July 21, 2017 | rss feed
Scientists may be able to minimize the failure rate of drugs for diseases linked to high-calorie diets, such as colon cancer and type 2 diabetes, if they test treatments using a pig model, according to an international team of... [read more]
Researchers show how hematopoietic stem cells detect and react to infections
July 20, 2017 | rss feed
Researchers at the University of Zurich have shown for the first time that hematopoietic stem cells detect infectious agents themselves and begin to divide - that is, without signals from growth... [read more]
Researchers find new way to protect stem cells from inflammation during wound repair
July 20, 2017 | rss feed
Scientists have found a new way to protect stem cells from harsh inflammation during wound repair. In a study recently published in the journal Cytotherapy, researchers in India discovered that treating mice with a common anti-inflammatory drug called... [read more]
New report highlights beneficial effects of nonmedical interventions for people with dementia
July 20, 2017 | rss feed
Managing lifestyle factors such as hearing loss, smoking, hypertension and depression could prevent one-third of the world's dementia cases, according to a report by the first Lancet Commission on Dementia Prevention and... [read more]
Researchers identify striking contrasts in how groups of neurons function during decision making
July 20, 2017 | rss feed
By training mice to perform a sound identification task in a virtual reality maze, researchers at Harvard Medical School and the Istituto Italiano di Tecnologia (IIT) have identified striking contrasts in how groups of neurons in different cortex... [read more]
Lunatic fringe gene plays role in regulating fate of neural stem cells
July 19, 2017 | rss feed
The discovery that the brain can generate new cells - about 700 new neurons each day - has triggered investigations to uncover how this process is... [read more]
New technique physically expands tissues to improve breast cancer diagnosis
July 18, 2017 | rss feed
A Ludwig Cancer Research study offers pathologists a quick, cheap and reliable tool to diagnose diseases such as early breast cancer with a conventional optical... [read more]
Immune system controls eye tissue regeneration in zebrafish, research finds
July 17, 2017 | rss feed
Researchers at Johns Hopkins Medicine report evidence that zebrafishes' natural ability to regenerate their eyes' retinal tissue can be accelerated by controlling the fishes' immune... [read more]
Infographic displays facts and information about stem cells, cord blood
July 17, 2017 | rss feed
Over 40,000 people have successfully stored stem cells with Smart Cells, however the industry is still relatively unknown and often subject to misinformation. In a bid to increase awareness and understanding of stem cell collection at birth, Smart... [read more]
Comparison of Non-Coding RNAs in Exosomes and Functional Efficacy of Human Embryonic Stem Cell- Versus Induced Pluripotent Stem Cell-Derived Cardiomyocytes
July 15, 2017 | rss feed
Background: Both human embryonic stem cell-derived cardiomyocytes (ESC-CMs) and human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) can serve as unlimited cell sources for cardiac regenerative therapy. However, the functional equivalency between human ESC-CMs and iPSC-CMs for... [read more]
UW-Madison researchers jump major hurdle on path toward wider use of stem cells
July 15, 2017 | rss feed
Since highly versatile human stem cells were discovered at the University of Wisconsin-Madison nearly 20 years ago, their path to the market and clinic has been slowed by a range of... [read more]
Ground-breaking new breast cancer drugs have manageable toxicity profile for most patients
July 13, 2017 | rss feed
A ground-breaking new class of oral drugs for treating breast cancer, known as cyclin-dependent kinase (CDK) inhibitors, are generally well-tolerated, with a manageable toxicity profile for most... [read more]
Skeletal Muscle Differentiation kit evaluated by leading French laboratory, I-Stem
July 13, 2017 | rss feed
AMSBIO reports on an independent evaluation and use by I-Stem (Corbeil-Essonnes, France) of the Skeletal Muscle Differentiation kit - a cell culture media system to differentiate human stem cells into functional... [read more]
Study assesses success and efficacy of ovarian tissue freezing
July 13, 2017 | rss feed
Many women are turning to egg freezing to promote fertility, but what happens when it isn't an option because of special medical or other conditions? And, what option is there for women who want to preserve hormonal function, not just... [read more]
Cord-blood-derived natural killer cells can be modified to destroy B-cell cancers
July 13, 2017 | rss feed
Immune cells with a general knack for recognizing and killing many types of infected or abnormal cells also can be engineered to hunt down cells with specific targets on them to treat cancer, researchers at The University of Texas MD Anderson Cancer... [read more]
Study reveals cells can be reprogrammed to repair severe liver injury
July 13, 2017 | rss feed
A new study has revealed that bile duct cells can switch to become normal liver cells to help repair the liver after severe... [read more]
New technology to manipulate cells could help treat Parkinson’s, arthritis, other diseases
July 12, 2017 | rss feed
DNA strands in materials act like traffic signals to start, stop cell activity or regenerate... [read more]
Research opens possibilities for effectively guiding stem cells to repair brain damage
July 12, 2017 | rss feed
Electric fields can be used to guide neural stem cells transplanted into the brain towards a specific location. The research, published July 11 in the journal Stem Cell Reports, opens possibilities for effectively guiding stem cells to repair brain... [read more]
Mesenchymal Stromal Cell-derived IL-6 Promotes Epithelial-mesenchymal Transition and Acquisition of Epithelial Stem-like Cell Properties in Ameloblastoma Epithelial Cells
July 12, 2017 | rss feed
Epithelial-mesenchymal transition (EMT), a biological process associated with cancer stem-like or cancer-initiating cell (CSC) formation, contributes to the invasiveness, metastasis, drug resistance, and recurrence of the malignant tumors; it remains to be determined whether similar processes... [read more]
Colorectal Cancer Stem Cells Acquire Chemoresistance through the Upregulation of FBXW7 and the Consequent Degradation of c-Myc
July 12, 2017 | rss feed
The cancer stem cell (CSC) paradigm suggests that tumors are organized hierarchically. We previously established an LGR5+ human colorectal cancer stem-cell-enriched cell line (colorectal CSCs) that expresses well-accepted colorectal CSC markers and that can dynamically switch between proliferative... [read more]
Acetylated STAT3 Functions as Molecular Adaptor Independent of Transcriptional Activity during Human Cardiogenesis
July 12, 2017 | rss feed
Activation of signal transducer and activator of transcription 3 (STAT3) is imperative for mammalian development, specifically cardiogenesis. STAT3 phosphorylation and acetylation are key post-translational modifications that regulate its transcriptional activity. Significance of such modifications... [read more]
Study shows potential of whole genome sequencing and AI to help clinicians scale precision oncology
July 12, 2017 | rss feed
In a study published today in the July 11, 2017 issue of Neurology Genetics, an official journal of the American Academy of Neurology, researchers at the New York Genome Center, The Rockefeller University and other NYGC member institutions, and IBM... [read more]
Graft-versus-host disease: Types, treatment, and outlook
July 11, 2017 | rss feed
Graft-versus-host disease, or GVHD, is a serious condition that can be fatal. In this article, learn about the types of GVHD, and how it is... [read more]
New technology could help patients requiring stem cell therapies for Parkinson’s, stroke, other diseases
July 11, 2017 | rss feed
A groundbreaking advancement in materials from Northwestern University could potentially help patients requiring stem cell therapies for spinal cord injuries, stroke, Parkinson's disease, Alzheimer's disease, arthritic joints or any other condition... [read more]
Scientists develop potential new therapy for targeting skin cancer metastases in the brain
July 11, 2017 | rss feed
Investigators from Brigham and Women's Hospital (BWH) and the Harvard Stem Cell Institute have a potential solution for how to kill tumor cells that have metastasized to the... [read more]
Stem Cell Educator therapy found to be safe and effective for treating diabetes
July 8, 2017 | rss feed
New research reveals that a treatment called Stem Cell Educator therapy is safe and effective for treating type 1 and type 2 diabetes. The therapy cultures the patient's immune cells with cord blood stem cells and returns only the "educated" immune... [read more]
Researchers make significant progress in engineering digestive system tissues
July 7, 2017 | rss feed
Researchers at Wake Forest Institute for Regenerative Medicine have reached important milestones in their quest to engineer replacement tissue in the lab to treat digestive system conditions -... [read more]
Some terminal cancer patients show unwillingness to face poor prognosis, study finds
July 6, 2017 | rss feed
In a recent study, published in The Oncologist, just under 10% of patients diagnosed with terminal cancer did not know their prognosis and had no interest in finding... [read more]
Loss of smell linked to weight loss in mice despite same food intake, study reveals
July 6, 2017 | rss feed
Experiments conducted at the University of California, Berkeley, suggest that the odor of food has a direct link with how the body processes the calories. The new study conducted on mice published in the first week of July in the journal Cell... [read more]
Gene mutation can cause brain malformation in children
July 6, 2017 | rss feed
Link between Dmrta2 gene and rare nervous system disorder.Researchers from Cardiff University and Université Libre de Bruxelles have identified how the function of a key gene... [read more]
Dmrta2 gene mutation can lead to abnormal brain development in unborn babies
July 6, 2017 | rss feed
Researchers from Cardiff University and Université Libre de Bruxelles have identified how the function of a key gene significantly impacts nerve stem cell growth, and how it can lead to abnormal brain development in unborn babies if the system goes... [read more]
Keck School of Medicine of USC awarded seven-year NIH grant for research on lung cell regeneration
July 6, 2017 | rss feed
The Keck School of Medicine of the University of Southern California is one of four institutions in California to receive a multimillion R35 grant from the National Institutes of Health's National Heart, Lung, and Blood Institute in... [read more]
Sense of smell may play key role in how the body deals with calories
July 6, 2017 | rss feed
Our sense of smell is key to the enjoyment of food, so it may be no surprise that in experiments at the University of California, Berkeley, obese mice who lost their sense of smell also lost... [read more]
High-throughput screening technique reveals new brain cancer drug targets
July 6, 2017 | rss feed
Researchers from Case Western Reserve University School of Medicine and The Cleveland Clinic designed a way to screen brain tumor cells and identify potential drug targets missed by other... [read more]
Cambridge scientists develop new method for growing and transplanting artificial bile ducts
July 4, 2017 | rss feed
Cambridge scientists have developed a new method for growing and transplanting artificial bile ducts that could in future be used to help treat liver disease in children, reducing the need for liver... [read more]
Research yields first successful isolation, maintenance of haploid embryonic stem cells in humans
June 29, 2017 | rss feed
Stem cell research holds huge potential for medicine and human health. In particular, human embryonic stem cells (ESCs), with their ability to turn into any cell in the human body, are essential to the future prevention and treatment of... [read more]
Why does hair turn gray?
June 29, 2017 | rss feed
When the inevitable first gray hair turns up, you might be wondering what biology is at play. Damaged stem cells in the hair follicle are to blame.... [read more]
Researchers trace origins of AML relapse to rare therapy-resistant stem cells
June 29, 2017 | rss feed
Leukemia researchers led by Dr. John Dick have traced the origins of relapse in acute myeloid leukemia (AML) to rare therapy-resistant leukemia stem cells that are already present at diagnosis and before chemotherapy... [read more]
Researchers discover protein that makes stem cells into perfect allrounders
June 29, 2017 | rss feed
Researchers from the University of Zurich and the University Hospital Zurich have discovered the protein that enables natural embryonic stem cells to form all body... [read more]
3D printing in medicine
June 27, 2017 | rss feed
We would normally divide the additive manufacturing technology into seven different groups. Whilst they all focus on building layer by layer, the way in which those layers are constructed varies according to the different type of additive... [read more]
What is hematopoietic stem cell transplantation?
June 26, 2017 | rss feed
Hematopoietic stem cell transplantation is approved for use in treating some types of cancer and is an experimental treatment for autoimmune... [read more]
Cover Image
June 26, 2017 | rss feed
Cover Art: Neuronal maturation: A representative image of immunostaining (×40) and magnification for TUJ1+ cells at day 33–44 of iPSC development. See Romero-Moya beginning on page... [read more]
Chicken models may shed light on how humans develop sensitive daytime vision
June 24, 2017 | rss feed
Humans belong to a select club of species that enjoy crisp color vision in daylight, thanks to a small spot in the center of the retina at the back of the... [read more]
Tiny biological nanoparticles offer enormous potential for diagnostic and therapeutic applications
June 23, 2017 | rss feed
Exosomes - tiny biological nanoparticles which transfer information between cells - offer significant potential in detecting and treating disease, the most comprehensive overview so far of research in the field has... [read more]
Researchers identify new way to effectively kill cancer stem cells using existing drugs
June 23, 2017 | rss feed
A team of researchers at McMaster University has identified a unique feature of cancer stem cells that can be exploited to kill the deadly cells thought to be the reason that cancer comes back after... [read more]
Human colon organoids fill gap in effectively modeling common GI diseases
June 23, 2017 | rss feed
Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice, according to research published June 22 in Cell Stem... [read more]
Could the mTOR pathway be used to protect against cancer?
June 22, 2017 | rss feed
The mTOR pathway is probably the main pathway in humans and other animals that drives growth. That is, the accumulation of mass and adding mass to make an organism bigger by both making more cells, and making cells grow and become... [read more]
Concise Review: Challenges in Regenerating the Diabetic Heart: A Comprehensive Review
June 22, 2017 | rss feed
Stem cell therapy is one of the promising regenerative strategies developed to improve cardiac function in patients with ischemic heart diseases (IHD). However, this approach is limited in IHD patients with diabetes due to a progressive decline in the regenerative capacity of stem cells. This... [read more]
Finnish researchers find accumulation of gene mutations in some patients with rheumatoid arthritis
June 21, 2017 | rss feed
Gene mutations accumulating in cells are typical of the development of cancer. Finnish researchers found that a similar accumulation of mutations occurs also in some patients with rheumatoid... [read more]
Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion
June 20, 2017 | rss feed
Human pluripotent stem cells (hPSC) require signaling provided by fibroblast growth factor (FGF) receptors. This can be initiated by the recombinant FGF2 ligand supplied exogenously, but hPSC further support their niche by secretion of endogenous FGF2. In this study, we describe a role of tyrosine... [read more]
Research findings lay groundwork for developing more targeted treatments for deadly neuroblastomas
June 20, 2017 | rss feed
Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine. The findings lay the groundwork for developing more targeted treatments for... [read more]
Grape-based compounds could pave way for new treatments to prevent colon cancer
June 19, 2017 | rss feed
Compounds from grapes may kill colon cancer stem cells both in a petri dish and in mice, according to a team of... [read more]
Researchers working towards developing novel stem cell approaches for glaucoma
June 16, 2017 | rss feed
There is great interest among glaucoma patients, scientists and doctors alike, in discovering regenerative therapies for the optic nerve and translating them from the laboratory to the clinic -; and stem cell therapy is one of several promising... [read more]
Long-distance brain connections can target, stimulate discrete pools of stem cells
June 16, 2017 | rss feed
Stem cells persist in the adult mammalian brain and generate new neurons throughout life. A research group at the Biozentrum of the University of Basel reports in the current issue of "Science" that long-distance brain connections can target discrete... [read more]
Heart failure: Stem cell therapy may worsen heart damage
June 16, 2017 | rss feed
For heart failure patients, research suggests that using cardiac stem cells for autologous stem cell therapy may exacerbate heart tissue... [read more]
Study reveals the body’s systemic stem cell response to ACL injury
June 16, 2017 | rss feed
You might think stem cells only exist inside a fetus, but your adult body has a stockpile of stem cells, armed and ready to respond. These remarkable cells can develop into any other type of cell, like muscle or bone or nerve... [read more]
Bioengineered human livers mimic natural development
June 16, 2017 | rss feed
An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes -... [read more]
Stem cell therapy may harm heart disease patients, study finds
June 15, 2017 | rss feed
Patients with severe and end-stage heart failure have few treatment options available to them apart from transplants and "miraculous" stem cell... [read more]
Researchers bioengineer human liver tissues that mimic natural development
June 15, 2017 | rss feed
An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes – greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent... [read more]
New research could help mitigate effects of radiation therapy
June 15, 2017 | rss feed
New research conducted at the University of Kansas Medical Center could make treatment for gastrointestinal cancers safer- while also helping to mitigate the dangers of nuclear accidents and terrorist... [read more]
TempTraq can detect rise in body temperature earlier than current SOC method, study shows
June 14, 2017 | rss feed
A University Hospitals Seidman Cancer Center study shows TempTraq, a patented, wearable, Bluetooth continuous temperature monitor in the form of a soft, comfortable patch, can detect a rise in body temperature up to 180 minutes earlier, in a majority... [read more]
USC scientists illuminate impact of early brain-clogging plaques on Alzheimer’s disease
June 14, 2017 | rss feed
Older adults with elevated levels of brain-clogging plaques -- but otherwise normal cognition -- experience faster mental decline suggestive of Alzheimer's disease, according to a new study led by the Keck School of Medicine of USC that looked at 10... [read more]
Combining vitamin C with antibiotics destroys cancer stem cells
June 13, 2017 | rss feed
When it comes to killing cancer stem cells - key drivers of cancer metastasis and recurrence - vitamin C and antibiotics can form a lethal... [read more]
Brief Report: External Beam Radiation Therapy for the Treatment of Human Pluripotent Stem Cell-Derived Teratomas
June 10, 2017 | rss feed
Human pluripotent stem cells, including human embryonic stem cells (hESCs) and human induced PSCs (hiPSCs), have great potential as an unlimited donor source for cell-based therapeutics. The risk of teratoma formation from residual undifferentiated cells, however, remains a critical barrier to the... [read more]
Allogeneic MSCs and Recycled Autologous Chondrons Mixed in a One-Stage Cartilage Cell Transplantion: A first-in-man trial in 35 patients
June 10, 2017 | rss feed
MSCs are known as multipotent mesenchymal stem cells that have been found capable of differentiating into various lineages including cartilage. However, recent studies suggest MSCs are pericytes that stimulate tissue repair through trophic signaling. Aimed at articular cartilage repair in a... [read more]
Interleukin-17A-Dependent Asymmetric Stem Cell Divisions Are Increased in Human Psoriasis: A Mechanism Underlying Benign Hyperproliferation
June 10, 2017 | rss feed
The balance between asymmetric and symmetric stem cell (SC) divisions is key to tissue homeostasis, and dysregulation of this balance has been shown in cancers. We hypothesized that the balance between asymmetric cell divisions (ACDs) and symmetric cell divisions (SCDs) would be dysregulated in the... [read more]
Elucidation of Altered Pathways in Tumor-Initiating Cells of Triple-Negative Breast Cancer: A Useful Cell Model System for Drug Screening
June 10, 2017 | rss feed
A limited number of cancer cells within a tumor are thought to have self-renewing and tumor-initiating capabilities that produce the remaining cancer cells in a heterogeneous tumor mass. Elucidation of central pathways preferentially used by tumor-initiating cells/cancer stem cells (CSCs) may allow... [read more]
Joslin Diabetes Center researchers establish CCTD to develop and translate cell-based interventions
June 10, 2017 | rss feed
Researchers and clinicians at Joslin Diabetes Center have established a Center for Cell-Based Therapy for Diabetes, the goal of which is to lead the development and translation of cell-based interventions to treat and cure diabetes and its... [read more]
Stem cells may be the key to staying strong in old age
June 8, 2017 | rss feed
University of Rochester Medical Center researchers have discovered that loss of muscle stem cells is the main driving force behind muscle decline in old age in... [read more]
Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function
June 7, 2017 | rss feed
Hippo pathway downstream effectors Yap and Taz play key roles in cell proliferation and regeneration, regulating gene expression especially via Tead transcription factors. To investigate their role in skeletal muscle stem cells, we analyzed Taz in vivo and ex vivo in comparison with Yap. Small... [read more]
Concise Review: Mesenchymal Stem Cells in Neurodegenerative Diseases
June 7, 2017 | rss feed
Stem cell-based therapies for neurodegenerative diseases aim at halting clinical deterioration by regeneration and by providing local support for damaged tissue. Mesenchymal stem cells (MSCs) hold great potential for cell therapy as they can be efficiently derived from adult tissue, ex vivo... [read more]
Scientists identify microtubule-based therapy to alleviate Gulf War Illness symptoms
June 7, 2017 | rss feed
At least 100,000 military veterans who served in the 1990-1991 Gulf War were exposed to chemical weapons, released into the air after the United States bombed an ammunition depot in Khamisiyah,... [read more]
New protocol offers faster and more effective way to obtain astrocytes from stem cells
June 7, 2017 | rss feed
Neurons have long enjoyed the spotlight in neuroscience--and for good reason: they are incredibly important cellular actors. But, increasingly, star-shaped support cells called astrocytes are being seen as more than bit players in the brain's rich... [read more]
Researchers uncover novel and non-invasive way to track dengue infection
June 7, 2017 | rss feed
Commonly used to detect solid tumors, positron emission tomography (PET) paired with the glucose metabolism probe, fluorodeoxyglucose (FDG), is considered 'old' technology in the field of... [read more]
UIC to open new center dedicated for stem cell and regenerative medicine
June 7, 2017 | rss feed
The University of Illinois at Chicago College of Medicine will launch a new center that will focus on understanding tissue regeneration and pioneering future developments in stem cell biology as a means to repair diseased organs and... [read more]
New discovery could have major impact on therapies to prevent spread of cancer
June 6, 2017 | rss feed
A research study led by University of Minnesota engineers gives new insight into how cancer cells move based on their ability to sense their environment. The discovery could have a major impact on therapies to prevent the spread of... [read more]
Stowers scientists provide evidence of cross-talk between Nanog and Hox genes
June 6, 2017 | rss feed
Competing regulatory genes "talk" to each other to maintain balance of cell state, according to new research from the Stowers Institute for Medical... [read more]
Mesenchymal Stem Cells Stabilize Axonal Transports for Autophagic Clearance of α-Synuclein in Parkinsonian Models
June 5, 2017 | rss feed
Genome-wide association studies have identified two loci, SNCA and the microtubule (MT)-associated protein tau, as common risk factors for Parkinson's disease (PD). Specifically, α-synuclein directly destabilizes MT via tau phosphorylation and induces axonal transport deficits that are the primary... [read more]
YY1 Expression Is Sufficient for the Maintenance of Cardiac Progenitor Cell State
June 5, 2017 | rss feed
During cardiac development, DNA binding transcription factors and epigenetic modifiers regulate gene expression in cardiac progenitor cells (CPCs). We have previously shown that Yin Yang 1 (YY1) is essential for the commitment of mesodermal precursors into CPCs. However, the role of YY1 in the... [read more]
A protein that stem cells require could be a target in killing breast cancer cells
June 5, 2017 | rss feed
For years, cancer experts have realized that cancerous cells behave in certain ways like stem cells, unspecialized cells that when exposed to certain signals, can... [read more]
Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a
June 3, 2017 | rss feed
The hematopoietically expressed homeobox transcription factor (Hhex) is important for the maturation of definitive hematopoietic progenitors and B-cells during development. We have recently shown that in adult hematopoiesis, Hhex is dispensable for maintenance of hematopoietic stem cells (HSCs) and... [read more]
Concise Reviews: Criteria for Chamber-Specific Categorization of Human Cardiac Myocytes Derived from Pluripotent Stem Cells
June 3, 2017 | rss feed
Human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have great potential application in almost all areas of cardiovascular research. A current major goal of the field is to build on the past success of differentiation strategies to produce CMs with the properties of those originating from... [read more]
Disrupting Interactions Between β-Catenin and Activating TCFs Reconstitutes Ground State Pluripotency in Mouse Embryonic Stem Cells
June 3, 2017 | rss feed
The 2i-media, composed of two small molecule inhibitors (PD0325901 and CHIR99021) against MEK and GSK3-kinases, respectively, is known to establish naïve ground state pluripotency in mouse embryonic stem cells (mESCs). These inhibitors block MEK-mediated differentiation, while driving β-catenin... [read more]