Stem Cell Applications

The following blurbs only serve to highlight the vast amount of Stem Cell Applications being researched with positive results. It should be obvious to even the most casual observer that it is optimal to have one’s body produce as many stem cells as possible….something that is truly possible with proper nutrition and a Stem Cell enhancement supplementation (i.e. Stem-Kine).

Stem cell researchers at Korea’s leading university and the RNL BioStem Cell Technology Institute were able to coax brains afflicted with Alzheimer’s disease to regenerate. They also found that stem cells can be used to prevent this disease. This was done using adult stem cells from fats of humans (National University and RNL Bio Stem Cell Technology Institute. Seoul, South Korea, Sept. 26,2012).

The Stem Cell Institute uses adult stem cells called allogeneic mesenchymal stem cells to treat rheumatoid arthritis. These cells are harvested from human umbilical cords donated after normal, healthy births. Allogeneic means “cells come from a matched related or unrelated donor.” Mesenchymal stem cells come from the surface of arteries. Therefore, the stem cells from the donor are accepted by the patient. Report was published by Stem Cell Institute in 2008.

The treatment of cancer with the use of stem cells involves stem cells from the bone marrow, peripheral blood and cord blood. These are taken from the patient before treatment with chemotherapy that destroy cancer cell. The reason is that chemotherapy would destroy them as well. Stem cells are grown and made to proliferate then injected back to the patient after chemotherapy. Stem cells that come from the patient himself/herself is called autologous; those from another matched related person is called allogeneic; those from a twin brother or sister is called syngeneic cells. Over time the grafted stem cells will grow and multiply in the bone marrow and supply blood to the patient (Bellomo, M. Stem Cell Divide. 2006).

Scientists at Gladstone Institute in San Francisco, USA, believe they are close to be able to replace damaged cells in the pancreas that leads to diabetes type I. They found this in laboratory mice. They took skin cells, reprogrammed them then coaxed them into pancreatic cells that secrete insulin. One week after the injection of reprogrammed stem cells, the sugar level of the mice approached normal level. Report was published in HealthDay on February 6,2014.

Heart failure occurs when the heart fails to pump enough blood to organs of the body. Causes can be cardiomyopathy, hypertension, heart valve problems and coronary artery disease.
The adult stem cells used to treat heart failure at the Stem Cell Institute come from human umbilical cord tissue (allogeneic mesenchymal). Allogeneic means “cells come from a matched related or unrelated donor.” Mesenchymal means stem cells from surface of artery. These stem cells stimulate dormant stem cells of the heart or become part of the heart to heal heart failure. They are expanded at Medistem Panama’s state-of-the-art laboratory. Results of study were released in 2010.

There are two general paths in treating heart disease with stem cell therapy. One path involves nutritional supplement that increases the population of stem cells in the bone marrow and endothelium pregenitor cells (EPC). EPCs circulate stem cells to home on the damaged heart and repair it. The product that is now in the market is Stem-Kine. Reports on this path are published in The Journal of Translational Medicine. The other path is the use of autologous cells (donor is the same person as the recipient) and allogeneic cells (donor is a matched person related to the recipient). Stem cells are taken from the heart or bone marrow. Stem cells for use in treatment are injected directly to the heart. Such procedures were done by the Harvard Medical School, USA in March 2013.

This disease is also called amyotrophic lateral sclerosis or motor neuron disease. During phase I trial, to ensure safety of treatment, “human fetal neural stem cells, cultivated by Neuralstem, have substantially slowed muscle degeneration” in patients. In the second phase of the trial, for efficacy, “the trial’s most impressive responder, Atlanta resident Ted Harada, who couldn’t walk without a cane before receiving one million cells, 500,000 on either side of his lower spine. Within months, in March 2011, he had abandoned the cane and participated in a 2.5 mile walkathon….” Results of study were reported by the ALS Clinic at the University of Michigan Health System in May 2013.

There are three regions in the lungs that produce stem cells that can be used in stem cell therapy. Stem cells can home and heal damaged parts of the lungs. One progeny stem cell is enough to multiply into a large population to replace the damaged lungs cells. This was reported in the ATS Journal, Volume 34, Issue 5 (May, 2006).

Parkinson’s disease results from the gradual loss of dopaminergic neurons. These produce dopamine, the lack of which makes moving freely, holding posture, writing and talking on the part of the patient difficult. One kind of cell has been identified with Parkinson’s disease. Therefore a remedy would be to replace such cell with those that can be obtained from embryonic stem cells or fetal brain tissue. In trials with fetal brain tissues were successfully transplanted resulting in improvement of patient. In another trial, the disease afflicted the transplanted cells. It appears that more dopaminergic neurons must be transplanted (eurostemcell. Neurological disorders. April 12,2011) While, more research must be done. The fact that doparminergic cells can be produced by means of reprogramming adult cells holds promise for treatment of Parkinson’s disease.

stemcell-application-2SICKLE CELL ANEMIA
A gene mutation results in “sickle cell disease (SCD), a painful, disabling inherited blood disorder that affects mostly African-Americans” according to researchers at Johns Hopkins Hospital. Such mutation can be corrected with the use of stem cells from the patient. “We’re now one step closer to developing a combination cell and gene therapy method that will allow us to use patients’ own cells to treat them,” according to Linzhao Cheng, Ph.D. of Johns Hopskins Institute for Cell Engineering. Results of study are published online in Blood, on August 28,2011.
Induced pluripotent stem cells were produced from bone marrow cells by reprogramming of patient’s bone marrow cells. One normal copy of hemoglobin gene (HbA) was inserted into the chromosome of the patient to replace the defective gene (Hba). Replacement is done by means of biotechnology called recombinant DNA (Cummings, N. Human Heredity. 2009).

Cesar Sebastiao was admitted to Beijing Puhua International Hospital on October 30th 2011 due to limb movement disorder. Sebastiao is 36 years old, male, from Brazil. Among other treatments, he underwent advance spinal cord reconstruction.
He also underwent an innovative and advanced spinal cord reconstruction. Cesar’s condition improved dramatically after the treatment. “Before he was discharged, wearing orthotics, he managed to stand up and walk forward with his hands holding a walker. This was impossible before the therapy, and will allow him to return to a relatively normal personal and professional life as a dentist in Brazil.”

Autologous mysenchymal stem cells were transplanted by infusion through an artery to patients of stroke. (Autologous means donor and recipient are the same person; mysenchymal means stem cells found in the surface of arteries). There was no side effect of transplants. “Outcomes improved in MSC-treated patients compared with the control patients….”
“In patients with severe cerebral infarcts (stroke), the intravenous infusion of autologous MSCs appears to be a feasible and safe therapy that may improve functional recovery.” Results of study were published in Annals of Neurology, volume 57, issue 6, June 2005, pages 874-882.

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