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What is a Stem Cell?

The most extraordinary cells in the human body are STEM CELLS. Stem cells are different from specialized cells in that they have the unique ability to convert into a multitude of different sorts of cells. Stem Cells can actually regenerate and replace damaged cells in the body. This has opened the doors for medical research that otherwise would not be possible. [read more]

BENEFITS OF STEM CELL RESEARCH

Out of all cells known to science, Stem Cells have the widest range of possible benefits for humans and other members of the Animal Kingdom. From illness and injury to vitality and cosmetic applications, Stem Cells are most probably the #1 key to improving comprehensive quality of life for all Earthlings.

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-Stem Cell Applications
-Health and Beauty

What is Stem-Kine?

Every moment of every day, your body is in a state of pre-disease, pre-illness, and depreciation due to ageing and environmental factors. Stem-Kine is a revolutionary product that ramps up the the production of Stem Cells by your body to promote a state of health and wellness that is out of reach for most people. [read more]

Healthcare Directory

From Massage Therapists to Medical Doctors and from Chiropractors to Nutrition Consultants --- Health Care Professionals agree that Stem Cell research and the practical applications are improving the quality of life for all. Please browse our database of those professionals who are dedicated to helping their clients achieve optimal health and wellness. [read more]

Latest Global Stem Cell News

Take me there

A Stem Cell Story

Dr. Neil Riordan talks about Stem Cell

EuroStemCell.org

Stem Cell Research

From 1908 when their existence was first hypothesized and the name “Stem Cell” was coined, it was then 70 years before definitive proof of their existence was shown in 1978.  In the decades since then, research employing Stem Cells as treatments and therapies has exploded off the charts with research being conducted on nearly all the continents.  The staff at StemCell101.com is dedicated to combing the internet, trade journals, and medical publications to bring consumers the latest information and news about this exciting and promising field.  [read more]

Stem Cell Applications

Without a doubt, the greatest development in the history of Stem Cell research has been the discovery that stem cell therapy can treat, reduce, and/or cure disease.  Moreover, whilst traditional methods of disease treatment may include invasive surgeries or prescription chemicals with harmful side effects, Stem Cell therapies are generally uncomplicated and straightforward and can be even as easy and painless as taking a daily pill. Overall, Stem Cell therapy is legal, ethical, effective, and safe. [read more]

Health and Beauty

Can aging be reversed or delayed?
The age-old quest for the fountain of youth has been pointing in the direction of stem cells for almost a decade now. Originally, stem cell research focused on stem cells harvested from embryonic sources. Fortunately, in the decades since their discovery, scientists have identified Adult Stem Cells which all humans possess in their bodies. These cells are being touted as the new waters of Bimini to regain youthfulness.   [read more]

Pets/Animals

The HSUS reported in 2012 that 62% of all American households included at least one furry child…either dog or cat. Specifically, about 84 million people have at least one dog and about 96 million have at least one cat.  As anyone with a furry companion knows, these little creatures entwine themselves into our lives and become part of the family.  As with humans, companion animals can also suffer from injuries, illness, and disease. Therefore, it is most advantageous that researches are also investigating and developing Stem Cell therapies for use in canines and felines.  [read more]

Stem Cell News

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Selectively deleting stem cell factor promotes recovery after TBI in mice
November 18, 2017 | rss feed
UT Southwestern molecular biologists today report the unexpected finding that selectively deleting a stem cell transcription factor in adult mice promotes recovery after traumatic brain injury... [read more]
Researchers uncover mechanism that contributes to patterns of degeneration in AD
November 17, 2017 | rss feed
Alzheimer's disease (AD) is known to cause memory loss and cognitive decline, but other functions of the brain can remain... [read more]
Old World monkeys could hold key to stop progression of rheumatoid arthritis
November 17, 2017 | rss feed
In the quest for a new and more effective treatment for rheumatoid arthritis, researchers from the Keck School of Medicine of USC looked to a primate that mostly roams the land in Asia, the Middle East and... [read more]
Drug used to prevent and treat malaria may also be effective for Zika virus
November 17, 2017 | rss feed
A new collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute and UC San Diego School of Medicine has found that a medication used to prevent and treat malaria may also be effective for Zika... [read more]
Type 1 diabetes: Could modified blood stem cells lead to a cure?
November 17, 2017 | rss feed
Researchers found that modifying blood stem cells to raise their levels of a T cell-blocking protein called PD-L1 reversed hyperglycemia in diabetic... [read more]
Brain astrocytes could play key role in pathogenesis of Alzheimer’s disease
November 17, 2017 | rss feed
Astrocytes, the supporting cells of the brain, could play a significant role in the pathogenesis of Alzheimer's disease (AD), according to a new study from the University of Eastern Finland. This is the first time researchers discovered a direct... [read more]
Breakthrough research brings new procedure closer to helping patients with blood cancer
November 17, 2017 | rss feed
A new procedure that can prevent the potentially lethal side effects of stem cell transplants is a step closer to helping more patients with blood cancers after a breakthrough in understanding of the key mechanism that makes it... [read more]
Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury
November 17, 2017 | rss feed
Production of an appropriate number of distinct cell types in precise locations during embryonic development is critical for proper tissue function. Homeostatic renewal or repair of damaged tissues in adults also requires cell expansion and transdifferentiation to replenish lost cells. However, the... [read more]
Stem cell treatment allows paraplegic rats to walk and regain sensory perception
November 17, 2017 | rss feed
Engineered tissue containing human stem cells has allowed paraplegic rats to walk independently and regain sensory... [read more]
Long non-coding RNA RP11-380D23.2 drives distal-proximal patterning of the lung by regulating PITX2 expression
November 16, 2017 | rss feed
Early lung development is a tightly orchestrated process encompassing (a) formation of definitive endoderm, (b) anteriorization of definitive endoderm followed by (c) specification and maturation of both proximal and distal lung precursors. Several reports detailing the interaction of genes and... [read more]
Stem cell therapy fails to improve walking ability in people with PAD
November 16, 2017 | rss feed
A stem cell therapy did not improve walking ability in people with peripheral artery disease, although exercise did lead to significant improvements, according to the results of a new Northwestern Medicine clinical... [read more]
Scientists find key that allows neural differentiation of microRNA-deficient pluripotent stem cells
November 15, 2017 | rss feed
The more than 200 different types of human cells have the same DNA but express different ensembles of genes. Each cell type was derived from embryonic stem cells, which are called pluripotent stem cells because they can differentiate to all those... [read more]
Notch1 and Notch2 Coordinately Regulate Stem Cell Function in the Quiescent and Activated States of Muscle Satellite Cells
November 15, 2017 | rss feed
Satellite cells, the muscle tissue stem cells, express three Notch receptors (Notch1–3). The function of Notch1 and Notch2 in satellite cells has to date not been fully evaluated. We investigated the role of Notch1 and Notch2 in myogenic progression in adult skeletal muscle using... [read more]
Notch1 and Notch2 Coordinately Regulate Stem Cell Function in the Quiescent and Activated States of Muscle Satellite Cells
November 15, 2017 | rss feed
Satellite cells, the muscle tissue stem cells, express three Notch receptors (Notch1–3). The function of Notch1 and Notch2 in satellite cells has to date not been fully evaluated. We investigated the role of Notch1 and Notch2 in myogenic progression in adult skeletal muscle using... [read more]
Single cell resolution of human hemato-endothelial cells defines transcriptional signatures of hemogenic endothelium
November 15, 2017 | rss feed
Endothelial-to-hematopoietic transition (EHT) is an important stage in definitive hematopoietic development. However, the genetic mechanisms underlying human EHT remains poorly characterized. We performed single cell RNA-seq using 55 hemogenic endothelial cells (HE:... [read more]
Single cell resolution of human hemato-endothelial cells defines transcriptional signatures of hemogenic endothelium
November 15, 2017 | rss feed
Endothelial-to-hematopoietic transition (EHT) is an important stage in definitive hematopoietic development. However, the genetic mechanisms underlying human EHT remains poorly characterized. We performed single cell RNA-seq using 55 hemogenic endothelial cells (HE:... [read more]
HAX-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation
November 15, 2017 | rss feed
Endothelial precursor cells (EPCs) are involved in vasculogenesis of various physiological and pathological processes. The proliferation and survival mechanism of EPCs needs to be explored further for the purpose of developing an effective glioma treatment. Hematopoietic-substrate-1 associated... [read more]
HAX-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation
November 15, 2017 | rss feed
Endothelial precursor cells (EPCs) are involved in vasculogenesis of various physiological and pathological processes. The proliferation and survival mechanism of EPCs needs to be explored further for the purpose of developing an effective glioma treatment. Hematopoietic-substrate-1 associated... [read more]
Study provides new insights into basis for responsiveness of testicular cancer to chemotherapy
November 15, 2017 | rss feed
Cornell researchers have taken a major step toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it... [read more]
Monoclonal antibody effectively blocks development of graft-versus-host disease, research shows
November 14, 2017 | rss feed
Newly published research provides preclinical proof-of-concept for the ability of PRO 140, a humanized anti-CCR5 monoclonal antibody under development by CytoDyn Inc., to effectively block the development of graft-versus-host disease (GvHD), a... [read more]
New drug shows promise in mouse model of autism disorder
November 14, 2017 | rss feed
Scientists have performed a successful test of a possible new drug in a mouse model of an autism disorder. The candidate drug, called NitroSynapsin, largely corrected electrical, behavioral and brain abnormalities in the... [read more]
Researchers find efficient way to produce neurons from pluripotent stem cells
November 13, 2017 | rss feed
Since their discovery in 2006, induced pluripotent stem cells are a glimmer of hope for many diseases. But further research of the complex regulation of pluripotent stem cell identity revealed unexpected... [read more]
Advances in genetic and stem cell techniques help identify therapeutic targets for neurological disorders
November 13, 2017 | rss feed
Research released today highlights advances in the use of CRISPR-Cas9 and human induced pluripotent stem cell technologies to identify novel therapeutic targets for neurological disorders such as schizophrenia and... [read more]
Advanced Cell Culture Models for Diamond Blackfan Anemia and other Erythroid Disorders
November 10, 2017 | rss feed
In vitro surrogate models of human erythropoiesis made many contributions to our understanding of the extrinsic and intrinsic regulation of this process in vivo and how they are altered in erythroid disorders. In the past, variability among the levels of hemoglobin F produced by adult erythroblasts... [read more]
Advanced Cell Culture Models for Diamond Blackfan Anemia and other Erythroid Disorders
November 10, 2017 | rss feed
In vitro surrogate models of human erythropoiesis made many contributions to our understanding of the extrinsic and intrinsic regulation of this process in vivo and how they are altered in erythroid disorders. In the past, variability among the levels of hemoglobin F produced by adult erythroblasts... [read more]
Advanced Cell Culture Models for Diamond Blackfan Anemia and other Erythroid Disorders
November 10, 2017 | rss feed
In vitro surrogate models of human erythropoiesis made many contributions to our understanding of the extrinsic and intrinsic regulation of this process in vivo and how they are altered in erythroid disorders. In the past, variability among the levels of hemoglobin F produced by adult erythroblasts... [read more]
Advanced Cell Culture Models for Diamond Blackfan Anemia and other Erythroid Disorders
November 10, 2017 | rss feed
In vitro surrogate models of human erythropoiesis made many contributions to our understanding of the extrinsic and intrinsic regulation of this process in vivo and how they are altered in erythroid disorders. In the past, variability among the levels of hemoglobin F produced by adult erythroblasts... [read more]
Advanced Cell Culture Models for Diamond Blackfan Anemia and other Erythroid Disorders
November 10, 2017 | rss feed
In vitro surrogate models of human erythropoiesis made many contributions to our understanding of the extrinsic and intrinsic regulation of this process in vivo and how they are altered in erythroid disorders. In the past, variability among the levels of hemoglobin F produced by adult erythroblasts... [read more]
3D cultured spheroids could drive precision treatment for ovarian cancer
November 9, 2017 | rss feed
Honeycomb-like arrays of tiny, lab-grown cancers could one day help doctors zero in on individualized treatments for ovarian cancer, an unpredictable disease that kills more than 14,000 women each year in the United States... [read more]
EIF5A2 Contributes to the Maintenance of CD133(+) Hepatocellular Carcinoma Cells via the c-Myc/microRNA-29b Axis
November 9, 2017 | rss feed
Cancer stem cells (CSCs)/cancer-initiating cells (CICs) are suggested responsible for driving cancer resistance to conventional therapies and for cancer recurrence and/or metastasis. CD133 is served as a key biomarker to identify and characterize this subpopulation of cells in hepatocellular... [read more]
How gene therapy saved a little boy’s life
November 8, 2017 | rss feed
Epidermolysis bullosa gives rise to painful blisters and chronic wounds. Doctors were sure that one little boy was going to lose his life — but he... [read more]
IUD use linked to dramatic decrease in incidence of cervical cancer
November 8, 2017 | rss feed
Considered a safe and highly effective contraception method, intrauterine devices (IUDs) may also be quietly offering protection against the third-most common cancer in women... [read more]
Stem cells could help improve blood circulation in diabetic patients with peripheral artery disease
November 7, 2017 | rss feed
Stem cells taken from muscle tissue could promote better blood flow in patients with diabetes who develop peripheral artery disease, a painful complication that can require surgery or lead to... [read more]
Study shows promise and potential risk in reversing hearing loss using inner ear stem cells
November 7, 2017 | rss feed
Want to restore hearing by injecting stem cells into the inner ear? Well, that can be a double-edged... [read more]
Production of nitric oxide crucial for stem cell mobilization and differentiation
November 2, 2017 | rss feed
Nathan Bryan, PH.D., one of the nation's leading experts on critically important role of nitric oxide in health and disease prevention, told attendees of the Pacific Regenerative Medicine 2017 Conference this morning that, "Stem cells are the future... [read more]
FDA issues warning letters to companies illegally selling products that claim to cure cancer
November 2, 2017 | rss feed
As part of the U.S. Food and Drug Administration's ongoing efforts to protect consumers from health fraud, the agency today issued warning letters to four companies illegally selling products online that claim to prevent, diagnose, treat, or cure... [read more]
FDA warning on miracle marijuana cures for cancer
November 2, 2017 | rss feed
Yesterday, 1st November 2017, the U.S. Food and Drug Administration, FDA, released a statement warning the general public against fraudulent claims regarding marijuana based cancer cures. The FDA has also issued warnings in writing to four companies... [read more]
Livecyte™ Cell Imaging and Analysis system adopted by the Translational Research Institute, Australia
November 1, 2017 | rss feed
The Translational Research Institute (TRI), Brisbane has become the first centre in Australia and the Asia Pacific region to adopt the Livecyte™ Cell Imaging and Analysis... [read more]
Conference to focus on preventing and reversing consequences of sickle cell disease
November 1, 2017 | rss feed
Leading experts in the field of sickle cell disease (SCD) research will convene in Washington, D.C., for the Physiological and Pathophysiological Consequences of Sickle Cell Disease conference (November 6–8). The conference, organized by the American... [read more]
Cleveland Clinic researcher awarded $2.6 million grant to create innovative models of colorectal cancer
October 31, 2017 | rss feed
Cleveland Clinic researcher Emina Huang, M.D., a colorectal surgeon in the Digestive Disease and Surgery Institute and a staff member in the Lerner Research Institute's Department of Stem Cell Biology and Regenerative Medicine, has been awarded a... [read more]
Stem cells do not participate directly in cartilage regeneration but serve to ‘animate’ the process
October 31, 2017 | rss feed
Stem cell therapy has great potential for curing cartilage damage. However, it has remained unclear whether stem cells are responsible for regeneration or whether they trigger the... [read more]
Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling
October 31, 2017 | rss feed
The ability to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes (CMs) makes them an attractive source for repairing injured myocardium, disease modeling, and drug testing. Although current differentiation protocols yield hPSC-CMs to >90% efficiency, hPSC-CMs exhibit... [read more]
Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling
October 31, 2017 | rss feed
Background: The ability to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes (CMs) makes them an attractive source for repairing injured myocardium, disease modeling, and drug testing. Although current differentiation protocols yield hPSC-CMs to >90% efficiency, hPSC-CMs... [read more]
Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration
October 31, 2017 | rss feed
Hematopoietic regeneration following chemotherapy may be distinct from regeneration following radiation. While we have shown that epidermal growth factor (EGF) accelerates regeneration following radiation, its role following chemotherapy is currently unknown. We sought to identify EGF as a... [read more]
Cover Image
October 28, 2017 | rss feed
Cover Art: iPSC can be generated from patients with age-related macular degeneration with the Y402H single nucleotide polymorphism in complement factor H. When differentiated to retinal pigmented epithelial cells, molecular, structural, and... [read more]
Inflammation-Stimulated Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Inflammation
October 27, 2017 | rss feed
Extracellular vesicles (EVs) secreted by mesenchymal stromal cells (MSCs) have been proposed to be a key mechanistic link in the therapeutic efficacy of cells in response to cellular injuries through paracrine effects. We hypothesize that inflammatory stimulation of MSCs results in the release of... [read more]
Brief Report: Three-Dimensional Culture Reduces Cell Size by Increasing Vesicle Excretion
October 27, 2017 | rss feed
Our previous study has shown that three-dimensional (3D) culture decreases mesenchymal stem cell (MSC) size, leading to enhanced trafficking ability and reduced lung vascular obstructions. However, the underlying mechanisms are unclear. In this study, we proposed that 3D culture reduces MSC size by... [read more]
Researchers find link between disrupted energy production and late-onset Alzheimer’s disease
October 27, 2017 | rss feed
A team of investigators from McLean Hospital and Harvard Medical School, led by Kai C. Sonntag, MD, PhD, and Bruce M. Cohen, MD, PhD, has found a connection between disrupted energy production and the development of late-onset Alzheimer's disease... [read more]
‘Precision Medicine’ may not always be so precise when applied to diverse populations, study says
October 27, 2017 | rss feed
Precision Medicine in oncology, where genetic testing is used to determine the best drugs to treat cancer patients, is not always so precise when applied to some of the world's more diverse populations, according to a study led by the Translational... [read more]
AMSBIO launches new service for synthesis of custom-designed synthetic mRNAs
October 26, 2017 | rss feed
AMSBIO announces the launch of a new service for synthesis of custom-designed, highly modified mRNAs prepared by an advantageous in vitro transcription... [read more]
JGU researchers develop new technique to facilitate differentiation of stem cells into neurons
October 26, 2017 | rss feed
Very little is still known about how neurons can be generated from stem cells. Researchers at the University Medical Center of Johannes Gutenberg University Mainz have now developed a promising technique that will facilitate the differentiation of... [read more]
VICC selected to administer FDA-approved CAR T therapy for treatment of lymphoma patients
October 26, 2017 | rss feed
Vanderbilt-Ingram Cancer Center has been selected as one of the few authorized treatment centers in the United States approved to administer the first FDA- approved chimeric antigen receptor T cell (CAR T) therapy for treatment of adult patients with... [read more]
Researchers develop new way to genetically engineer T cells for treating leukemia relapse
October 25, 2017 | rss feed
Researchers at Fred Hutchinson Cancer Research Center and the University of Washington have developed a novel way to genetically engineer T cells that may be effective for treating and preventing leukemia... [read more]
A Novel Construction of Lentiviral Vectors for Eliminating Tumorigenic Cells from Pluripotent Stem Cells
October 25, 2017 | rss feed
The risk of tumor formation poses a challenge for human pluripotent stem cell (hPSC)-based transplantation therapy. Specific and total elimination of tumorigenic hPSCs by suicide genes (SGs) has not been achieved because no methodology currently exists for testing multiple candidate transgene... [read more]
Brief Report: Survivin Is Required for Mouse and Human Bone Marrow Mesenchymal Stromal Cell Function
October 25, 2017 | rss feed
Although mesenchymal stromal cells (MSCs) have significant potential in cell-based therapies, little is known about the factors that regulate their functions. While exploring regulatory molecules potentially involved in MSC activities, we found that the endogenous multifunctional factor Survivin is... [read more]
The Pericytic Phenotype of Adipose Tissue-Derived Stromal Cells Is Promoted by NOTCH2
October 25, 2017 | rss feed
Long-term diabetes leads to macrovascular and microvascular complication. In diabetic retinopathy (DR), persistent hyperglycemia causes permanent loss of retinal pericytes and aberrant proliferation of microvascular endothelial cells (EC). Adipose tissue-derived stromal cells (ASC) may serve to... [read more]
Scientists develop unique CRISPR-based method for more precise, systematic gene tagging
October 25, 2017 | rss feed
The genome editing tool known as CRISPR/Cas9 has opened many doors for biomedical research by allowing scientists to precisely edit DNA sequences and alter function. The technology offers hope for correcting genetic defects and preventing... [read more]
Scientists develop unique CRISPR-based method for more precise, systematic gene tagging
October 25, 2017 | rss feed
The genome editing tool known as CRISPR/Cas9 has opened many doors for biomedical research by allowing scientists to precisely edit DNA sequences and alter function. The technology offers hope for correcting genetic defects and preventing... [read more]
Researchers evaluate potential of stem cells, therapeutic agents in neurodegenerative diseases
October 25, 2017 | rss feed
As the brain has limited capability for self-repair or regeneration, stem cells may represent the best therapeutic approach for counteracting damage to or degeneration of brain tissue caused by injury, aging, or... [read more]
Stem cell researchers make advance toward long-lasting blood vessel repair
October 24, 2017 | rss feed
Stem cell researchers at Emory University School of Medicine have made an advance toward having a long-lasting "repair caulk" for blood vessels. The research could form the basis of a treatment for peripheral artery disease, derived from a patient's... [read more]
Scientists develop physiological approach to restore gut’s ecosystem in various diseases
October 24, 2017 | rss feed
The trillions of microbes living in a mammal's intestine play an important role in the host's metabolism and immunity. The composition of microbiota is maintained by antimicrobial proteins secreted from intestinal... [read more]
Adipose-derived stem cell clinical trial focuses on non-healing leg wounds
October 20, 2017 | rss feed
Sanford Health is launching its second adipose-derived stem cell clinical trial - this one to focus on non-healing leg... [read more]
Adipose-derived stem cell clinical trial focuses on non-healing leg wounds
October 20, 2017 | rss feed
Sanford Health is launching its second adipose-derived stem cell clinical trial - this one to focus on non-healing leg... [read more]
Researchers reveal how certain nerves sustain prostate cancer growth
October 20, 2017 | rss feed
In a study in today's issue of Science, researchers at Albert Einstein College of Medicine, part of Montefiore Medicine, report that certain nerves sustain prostate cancer growth by triggering a switch that causes tumor vessels to... [read more]
Pluripotent Stem Cell Derived Haematopoietic Progenitors Are Unable To Downregulate Key EMT-Associated miRNAs
October 19, 2017 | rss feed
Haematopoietic stem cells derived from pluripotent stem cells could be used as an alternative to bone marrow transplants. Deriving these has been a long-term goal for researchers. However, the success of these efforts has been limited, with the cells produced able to engraft in the bone marrow of... [read more]
Brief Report: Pluripotent Stem Cell-Derived Hematopoietic Progenitors Are Unable to Downregulate Key Epithelial-Mesenchymal Transition-Associated miRNAs
October 19, 2017 | rss feed
Hematopoietic stem cells derived from pluripotent stem cells could be used as an alternative to bone marrow transplants. Deriving these has been a long-term goal for researchers. However, the success of these efforts has been limited with the cells produced able to engraft in the bone marrow of... [read more]
Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells
October 19, 2017 | rss feed
Mammalian skin and its appendages constitute the integumentary system forming a barrier between the organism and its environment. During development, skin epidermal cells divide rapidly and stratify into a multilayered epithelium, as well as invaginate downward in the underlying mesenchyme to form... [read more]
Cornell study reveals how UV radiation triggers melanoma
October 18, 2017 | rss feed
Melanoma, a cancer of skin pigment cells called melanocytes, will strike an estimated 87,110 people in the U.S. in 2017, according to the Centers for Disease Control and Prevention. A fraction of those melanomas come from pre-existing moles, but the... [read more]
UAB researchers report major advance in efforts to repair damaged heart after heart attack
October 17, 2017 | rss feed
University of Alabama at Birmingham biomedical engineers report a significant advance in efforts to repair a damaged heart after a heart attack, using grafted heart-muscle cells to create a repair... [read more]
Researchers identify strategies to mitigate disturbed axonal transport in ALS patients
October 17, 2017 | rss feed
A team of researchers at VIB and KU Leuven used stem cell technology to generate motor neurons from ALS patients carrying mutations in FUS. They found disturbed axonal transport in these motor neurons, but also identified genetic and pharmacological... [read more]
Using AFM to study cell mechanics and function
October 17, 2017 | rss feed
My lab, broadly speaking, is interested in trying to understand interactions between cells and materials. Those could be materials that are present within living tissue or materials that we use for engineering purposes to try to do something of... [read more]
Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet-Derived Growth Factor on Human Retinal Ganglion Cells
October 17, 2017 | rss feed
Optic neuropathies such as glaucoma occur when retinal ganglion cells (RGCs) in the eye are injured. Strong evidence suggests mesenchymal stem cells (MSCs) could be a potential therapy to protect RGCs, however little is known regarding their effect on the human retina. We, therefore, investigated... [read more]
Columbia scientists receive grant from CZI to construct atlas of cells in human spinal cord
October 17, 2017 | rss feed
Scientists at Columbia's Zuckerman Institute today received a grant from the Chan Zuckerberg Initiative donor advised fund, an advised fund of the Silicon Valley Community Foundation, to construct an atlas of gene activity of all cells in the human... [read more]
Mouse Parthenogenetic Embryonic Stem Cells with Biparental-Like Expression of Imprinted Genes Generate Cortical-Like Neurons That Integrate into the Injured Adult Cerebral Cortex
October 17, 2017 | rss feed
One strategy for stem cell-based therapy of the cerebral cortex involves the generation and transplantation of functional, histocompatible cortical-like neurons from embryonic stem cells (ESCs). Diploid parthenogenetic Pg-ESCs have recently emerged as a promising source of histocompatible ESC... [read more]
Sox2 Communicates With Tregs Through CCL1 To Promote The Stemness Property Of Breast Cancer Cells
October 17, 2017 | rss feed
As an important component of tumor microenvrionment, CD4+CD25+ Tregs reduce antitumor immunity, promote angiogenesis and metastasis in breast cancer. However, their function in regulating the "stemness" of tumor cells and the communication between Tregs and cancer stem cells (CSCs) remain... [read more]
Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature
October 17, 2017 | rss feed
A long-standing question in biology is whether multipotent somatic stem and progenitor cells (SSPCs) feature molecular properties that could guide their system-independent identification. Population-based transcriptomic studies have so far not been able to provide a definite answer, given the... [read more]
Powering up fat cells could help acute myeloid leukemia patients
October 16, 2017 | rss feed
Killing cancer cells indirectly by powering up fat cells in the bone marrow could help acute myeloid leukemia patients, according to a new study from McMaster... [read more]
Researchers to investigate cellular changes leading to development of glioblastoma
October 16, 2017 | rss feed
Glioblastoma is the most common of malign brain tumors in adults, and it currently has no cure. Now a research team led by Dr Claudia Barros, from the Plymouth University Peninsula Schools of Medicine and Dentistry and its Brain Tumour Research-funded... [read more]
Specific regions of silenced DNA help define cell’s identity, study suggests
October 13, 2017 | rss feed
The fundamental mechanisms governing how cells form an identity such as becoming a muscle cell or a nerve cell are not fully understood. Multiple diseases, including cancer, have been linked to cells going down the wrong developmental path during... [read more]
Subtle Deregulation of the Wnt-Signaling Pathway Through Loss of Apc2 Reduces the Fitness of Intestinal Stem Cells
October 13, 2017 | rss feed
The importance of the Wnt-signaling pathway on the regulation and maintenance of the intestinal stem cell (ISC) population is well recognized. However, our current knowledge base is founded on models using systems of gross deregulation of the Wnt-signaling pathway. Given the importance of this... [read more]
Researchers find multiple new mutations linked to autism in children but not their parents
October 13, 2017 | rss feed
Most cases of autism appear to be associated with the appearance of new mutations that are not inherited from the child's parents, researchers from the University of Washington School of Medicine... [read more]
Are stem cells and regenerative medicine living up to their promises?
October 11, 2017 | rss feed
The use of stem cells, materials, or molecules to regenerate tissues and organs promises to revolutionize medicine. How long until this becomes... [read more]
Mesenchymal Stromal Cell-Derived Extracellular Vesicles Provide Long-Term Survival After Total Body Irradiation Without Additional Hematopoietic Stem Cell Support
October 11, 2017 | rss feed
The therapeutic effect of mesenchymal stromal cells (MSC) in tissue regeneration is based mainly on the secretion of bioactive molecules. Here, we report that the radioprotective effect of mouse bone marrow derived mesenchymal stromal cells (mMSC) can be attributed to extracellular vesicles (EV)... [read more]
Mesenchymal Stromal Cell-Derived Extracellular Vesicles Provide Long-term Survival after Total Body Irradiation without additional Hematopoietic Stem Cell Support
October 11, 2017 | rss feed
The therapeutic effect of mesenchymal stromal cells (MSC) in tissue regeneration is based mainly on the secretion of bioactive molecules. Here, we report that the radioprotective effect of mouse bone marrow derived MSC (mMSC) can be attributed to extracellular vesicles (EV) released from mMSC. The... [read more]
Mesenchymal Stromal Cell-Derived Extracellular Vesicles Provide Long-term Survival after Total Body Irradiation without additional Hematopoietic Stem Cell Support
October 11, 2017 | rss feed
The therapeutic effect of mesenchymal stromal cells (MSC) in tissue regeneration is based mainly on the secretion of bioactive molecules. Here, we report that the radioprotective effect of mouse bone marrow derived MSC (mMSC) can be attributed to extracellular vesicles (EV) released from mMSC. The... [read more]
Mesenchymal Stromal Cell-Derived Extracellular Vesicles Provide Long-term Survival after Total Body Irradiation without additional Hematopoietic Stem Cell Support
October 11, 2017 | rss feed
The therapeutic effect of mesenchymal stromal cells (MSC) in tissue regeneration is based mainly on the secretion of bioactive molecules. Here, we report that the radioprotective effect of mouse bone marrow derived MSC (mMSC) can be attributed to extracellular vesicles (EV) released from mMSC. The... [read more]
Emerging Principles from the Clinical Application of Chimeric Antigen Receptor (CAR) T Cell Therapies for B Cell Malignancies
October 11, 2017 | rss feed
Gene-engineered T cell therapies are soon to be FDA approved for at least two types of B cell malignancies in pediatric and adult patients, in the form of CD19 targeted chimeric antigen receptor T (CAR T) cell therapy. This represents a triumph of a true bench to bedside clinical translation of a... [read more]
Emerging Principles from the Clinical Application of Chimeric Antigen Receptor (CAR) T Cell Therapies for B Cell Malignancies
October 11, 2017 | rss feed
Gene-engineered T cell therapies are soon to be FDA approved for at least two types of B cell malignancies in pediatric and adult patients, in the form of CD19 targeted chimeric antigen receptor T (CAR T) cell therapy. This represents a triumph of a true bench to bedside clinical translation of a... [read more]
Concise Review: Emerging Principles from the Clinical Application of Chimeric Antigen Receptor T Cell Therapies for B Cell Malignancies
October 11, 2017 | rss feed
Gene-engineered T cell therapies are soon to be United States Food and Drug Administration (FDA) approved for at least two types of B cell malignancies in pediatric and adult patients, in the form of CD19 targeted chimeric antigen receptor T (CAR T) cell therapy. This represents a triumph of a true... [read more]
Emerging Principles from the Clinical Application of Chimeric Antigen Receptor (CAR) T Cell Therapies for B Cell Malignancies
October 11, 2017 | rss feed
Gene-engineered T cell therapies are soon to be FDA approved for at least two types of B cell malignancies in pediatric and adult patients, in the form of CD19 targeted chimeric antigen receptor T (CAR T) cell therapy. This represents a triumph of a true bench to bedside clinical translation of a... [read more]
Scientists find new way to produce brain cells from single iPSC
October 11, 2017 | rss feed
Li Gan, PhD, wants to find treatments to help patients with Alzheimer's disease. Like most researchers, she's hit a few major... [read more]
Researchers propose LSD1 protein as central player in Alzheimer’s and FTD
October 9, 2017 | rss feed
Removal of a regulatory gene called LSD1 in adult mice induces changes in gene activity that that look unexpectedly like Alzheimer's disease, scientists have... [read more]
New microcapsules represent promising vectors for application of genome-editing tools
October 7, 2017 | rss feed
Researchers from Tomsk Polytechnic University jointly with their colleagues from St. Petersburg, Hamburg and London have conducted a study in the course of which it was found out that polymer and hybrid silica-coated microcapsules are more efficient... [read more]
CGT Catapult’s iPSC line licensed to Universal Cells for creating universal donor cell line
October 6, 2017 | rss feed
The Cell and Gene Therapy Catapult today announced a non-exclusive licensing agreement to provide its clinical-grade induced Pluripotent Stem Cell line to Seattle based Universal... [read more]
New cell therapy restores movement in people with paralyzing spinal cord injuries
October 6, 2017 | rss feed
Four of six people with paralyzing spinal cord injuries who were treated with a new cell therapy have recovered two or more motor levels on at least one side, new study results... [read more]
Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State
October 6, 2017 | rss feed
Recently, the field of stem cell-based regeneration has turned its attention toward chemical approaches for controlling the pluripotency and differentiation of embryonic stem cells (ESCs) using drug-like small molecule modulators. Growth factor receptors or their associated downstream kinases that... [read more]
Good-guy bacteria may help individuals respond well to cancer immunotherapy
October 6, 2017 | rss feed
Individuals with certain types of bacteria in their gut may be more likely to respond well to cancer immunotherapy, researchers at the Harold C. Simmons Comprehensive Cancer Center found in a study of patients with metastatic... [read more]
Study sheds light on complex process involved in development of sperm stem cells
October 6, 2017 | rss feed
New research from scientists at Huntsman Cancer Institute at the University of Utah and collaborators at University of Utah Health sheds light on the complex process that occurs in the development of human sperm stem... [read more]

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