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What is a Stem Cell?

The most extraordinary cells in the human body are STEM CELLS. Stem cells are different from specialized cells in that they have the unique ability to convert into a multitude of different sorts of cells. Stem Cells can actually regenerate and replace damaged cells in the body. This has opened the doors for medical research that otherwise would not be possible. [read more]

BENEFITS OF STEM CELL RESEARCH

Out of all cells known to science, Stem Cells have the widest range of possible benefits for humans and other members of the Animal Kingdom. From illness and injury to vitality and cosmetic applications, Stem Cells are most probably the #1 key to improving comprehensive quality of life for all Earthlings.

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-Stem Cell Applications
-Health and Beauty

What is Stem-Kine?

Every moment of every day, your body is in a state of pre-disease, pre-illness, and depreciation due to ageing and environmental factors. Stem-Kine is a revolutionary product that ramps up the the production of Stem Cells by your body to promote a state of health and wellness that is out of reach for most people. [read more]

Healthcare Directory

From Massage Therapists to Medical Doctors and from Chiropractors to Nutrition Consultants --- Health Care Professionals agree that Stem Cell research and the practical applications are improving the quality of life for all. Please browse our database of those professionals who are dedicated to helping their clients achieve optimal health and wellness. [read more]

Latest Global Stem Cell News

Take me there

A Stem Cell Story

Dr. Neil Riordan talks about Stem Cell

EuroStemCell.org

Stem Cell Research

From 1908 when their existence was first hypothesized and the name “Stem Cell” was coined, it was then 70 years before definitive proof of their existence was shown in 1978.  In the decades since then, research employing Stem Cells as treatments and therapies has exploded off the charts with research being conducted on nearly all the continents.  The staff at StemCell101.com is dedicated to combing the internet, trade journals, and medical publications to bring consumers the latest information and news about this exciting and promising field.  [read more]

Stem Cell Applications

Without a doubt, the greatest development in the history of Stem Cell research has been the discovery that stem cell therapy can treat, reduce, and/or cure disease.  Moreover, whilst traditional methods of disease treatment may include invasive surgeries or prescription chemicals with harmful side effects, Stem Cell therapies are generally uncomplicated and straightforward and can be even as easy and painless as taking a daily pill. Overall, Stem Cell therapy is legal, ethical, effective, and safe. [read more]

Health and Beauty

Can aging be reversed or delayed?
The age-old quest for the fountain of youth has been pointing in the direction of stem cells for almost a decade now. Originally, stem cell research focused on stem cells harvested from embryonic sources. Fortunately, in the decades since their discovery, scientists have identified Adult Stem Cells which all humans possess in their bodies. These cells are being touted as the new waters of Bimini to regain youthfulness.   [read more]

Pets/Animals

The HSUS reported in 2012 that 62% of all American households included at least one furry child…either dog or cat. Specifically, about 84 million people have at least one dog and about 96 million have at least one cat.  As anyone with a furry companion knows, these little creatures entwine themselves into our lives and become part of the family.  As with humans, companion animals can also suffer from injuries, illness, and disease. Therefore, it is most advantageous that researches are also investigating and developing Stem Cell therapies for use in canines and felines.  [read more]

Stem Cell News

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Modular gene enhancers may be suitable target in treatment of blood cancer
January 18, 2018 | rss feed
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in... [read more]
Human Induced Pluripotent Stem Cell Models Of Retinitis Pigmentosa
January 18, 2018 | rss feed
Hereditary retinal dystrophies, specifically retinitis pigmentosa (RP) are clinically and genetically heterogeneous diseases affecting primarily retinal cells and retinal pigment epithelial (RPE) cells with blindness as a final outcome. Understanding the pathogenicity behind these diseases has been... [read more]
Being Pluripotent, Bone Marrow VSELs Rather than HSCs have the Potential to Regenerate other Adult Organs
January 18, 2018 | rss feed
Recent study by Deanne's group provides evidence that transplanted GFP positive bone marrow hematopoietic stem cells (HSCs) expressing CD45 do not regenerate the endometrium of irradiated mice. The results do not surprise us since global efforts to regenerate various organs by transplanting bone... [read more]
Three-dimensional organization of genome plays key role in gene expression, cell fate
January 17, 2018 | rss feed
Scientists have long been reading the code of life - the genome -, as a sequence of letters but now researchers have also started exploring its three-dimensional... [read more]
EXD2 enzyme facilitates protein production in mitochondria
January 17, 2018 | rss feed
Researchers from the Genomic Instability and Cancer Laboratory at Institute for Research in Biomedicine (IRB Barcelona) have identified a key role for EXD2 in protein production in the mitochondria, the cellular organelles responsible for the majority... [read more]
Immunomodulation by Therapeutic Mesenchymal Stromal Cells (MSC) is Triggered Through Phagocytosis of MSC by Monocytic Cells
January 17, 2018 | rss feed
Mesenchymal stem or stromal cells (MSC) are under investigation as a potential immunotherapy. MSC are usually administered via intravenous infusion, after which they are trapped in the lungs and die and disappear within a day. The fate of MSC after their disappearance from the lungs is unknown and... [read more]
Cornea Derived MSCs Therapeutically Modulate Macrophage Immunophenotype And Angiogenic Function
January 17, 2018 | rss feed
Macrophages are crucial drivers of inflammatory corneal neovascularization and thus are potential targets for immunomodulatory therapies. We hypothesized that therapeutic use of cornea derived mesenchymal stromal cells (cMSCs) may alter the function of macrophages. We found that cMSCs can modulate... [read more]
Epigenetic Silencing Of TAP1 In Aldefluor+ Breast Cancer Stem Cells Contributes To Their Enhanced Immune Evasion
January 17, 2018 | rss feed
Avoiding detection and destruction by immune cells is key for tumor initiation and progression. The important role of cancer stem cells (CSC) in tumor initiation has been well established, yet their ability to evade immune detection and targeting is only partly understood. To investigate the... [read more]
AMSBIO’s new recombinant protein shows great promise for organoid culture
January 16, 2018 | rss feed
AMSBIO has introduced recombinant Wnt3a with a new Wnt stabilizer that significantly extends the activity of this protein in serum-free medium from a half-life of just 2 hours to around 30... [read more]
AMSBIO’s new recombinant protein shows great promise for organoid culture
January 16, 2018 | rss feed
AMSBIO has introduced recombinant Wnt3a with a new Wnt stabilizer that significantly extends the activity of this protein in serum-free medium from a half-life of just 2 hours to around 30... [read more]
Concise Review: Optimized Strategies for Stem Cell-based Therapy in Myocardial Repair: Clinical Translatability and Potential Limitation
January 13, 2018 | rss feed
Ischemic heart diseases (IHDs) remain major public health problems with high rates of morbidity and mortality worldwide. Despite significant advances, current therapeutic approaches are unable to rescue the extensive and irreversible loss of cardiomyocytes caused by severe ischemia. Over the past... [read more]
Stem cell transplant can effectively treat patients with rare autoimmune disease, study shows
January 13, 2018 | rss feed
An unusual autoimmune disease that causes skin and lung damage can be treated effectively by stem cell transplant, a new study in the New England Journal of Medicine has... [read more]
Research provides insights into mechanisms governing healthy longevity
January 12, 2018 | rss feed
Keio University Global Research Institute, Tokyo publishes the January 2018 issue of KGRI Research Frontiers that includes researcher video profiles of Keio University researchers and research highlights from high impact publications including... [read more]
ERBB3-Binding Protein (EBP1) is a novel DPPA4 cofactor in human pluripotent cells
January 12, 2018 | rss feed
Developmental Pluripotency-Associated-4 (DPPA4) is one of the few core pluripotency genes lacking clearly defined molecular and cellular functions. Here we used a proteomics screening approach of human embryonic stem cell (hESC) nuclear extract to determine DPPA4 molecular functions through... [read more]
PLGA-mPEG Nanoparticles Loaded with Melatonin Protect Adipose-derived Stem Cells Transplanted in Infarcted Heart Tissue
January 12, 2018 | rss feed
Stem cell transplantation is a promising therapeutic strategy for myocardial infarction. However, transplanted cells face low survival rates due to oxidative stress and the inflammatory microenvironment in ischemic heart tissue. Melatonin has been used as a powerful endogenous antioxidant to... [read more]
Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-derived Retinal Organoids and Fetal Retinae
January 12, 2018 | rss feed
Loss of photoreceptor cells due to retinal degeneration is one of the main causes of blindness in the developed world. Although there is currently no effective treatment, cell replacement therapy using stem-cell-derived photoreceptor cells may be a feasible future treatment option. In order to... [read more]
UCLA scientists coax human stem cells to become sensory interneurons
January 12, 2018 | rss feed
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons -- the cells that give us our sense of... [read more]
Decorated cardiac stem cells could provide enhanced treatment for heart attacks
January 11, 2018 | rss feed
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains... [read more]
UC scientists identify protein that acts as mediator of HER2-driven breast cancer
January 10, 2018 | rss feed
Researchers at the University of Cincinnati College of Medicine have identified for the first time that the estrogen receptor-binding protein MED1 is a critical mediator of HER2-driven breast cancer, identifying it as a potential therapeutic... [read more]
Researchers uncover powerful new model for studying hallmark of vascular disease
January 10, 2018 | rss feed
While refining ways to grow arterial endothelial cells in the lab, a regenerative biology team at the Morgridge Institute for Research at the University of Wisconsin-Madison unexpectedly unearthed a powerful new model for studying a hallmark of... [read more]
New blood stabilization method prolongs lifespan of blood samples for CTC profiling
January 10, 2018 | rss feed
A new blood stabilization method, developed at the Massachusetts General Hospital Center for Engineering in Medicine, significantly prolongs the lifespan of blood samples for microfluidic sorting and transcriptome profiling of rare circulating tumor... [read more]
HSS researchers win grant to determine if stem cell therapy can improve outcomes for rotator cuff tears
January 6, 2018 | rss feed
A multidisciplinary team led by Scott Rodeo, MD, and Christopher Mendias, PhD, at Hospital for Special Surgery has been awarded the Orthopaedic Research and Education Foundation Clinical Research Grant in Cellular Therapy in honor of James Urbaniak,... [read more]
Stem cell transplant improves survival among scleroderma patients
January 6, 2018 | rss feed
Scleroderma with internal organ involvement is a debilitating and lethal autoimmune disorder with few effective treatments. But a study led by Duke Health researchers has found new cause for optimism using an aggressive stem cell transplant... [read more]
Precision editing of gut bacteria reduces inflammation in mouse model of colitis
January 6, 2018 | rss feed
UT Southwestern Medical Center researchers have used precision editing of the bacterial populations in the gut to prevent or reduce the severity of inflammation in a mouse model of... [read more]
UC Davis expert expresses caution on genetically engineered HSCs
January 5, 2018 | rss feed
In a commentary published in the Jan. 4 issue of the New England Journal of Medicine, UC Davis researcher William Murphy expressed cautious optimism about efforts to genetically engineer hematopoietic stem cells (HSCs) to temporarily resist cell death... [read more]
Phase III clinical study of regenerative therapy for treating damaged cartilage has started
January 5, 2018 | rss feed
A group of researchers at Osaka University developed a synthetic tissue using synovium-derived mesenchymal stem cells (MSCs) for treating damaged cartilage, which had previously been incurable and had no effective... [read more]
Study reveals a loophole in treatment of chronic lymphocytic leukemia
January 4, 2018 | rss feed
A team of researchers in Italy and Austria has determined that a drug approved to treat chronic lymphocytic leukemia (CLL) may be less effective in a particular subset of... [read more]
Genetic labeling helps researchers track behavior of blood cells
January 4, 2018 | rss feed
By tagging bone marrow cells of mice with a genetic label, or barcode, researchers were able to track and describe the family tree of individual blood cells as they form in their natural... [read more]
A-Kinase Anchor Protein 12 is Required for Oligodendrocyte Differentiation in Adult White Matter
January 4, 2018 | rss feed
Oligodendrocyte precursor cells (OPCs) give rise to oligodendrocytes in cerebral white matter. However, the underlying mechanisms that regulate this process remain to be fully defined, especially in adult brains. Recently, it has been suggested that signaling via A-kinase anchor protein 12... [read more]
Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem Cells
January 4, 2018 | rss feed
Tendon repair is a clinical challenge because of the limited understanding on tenogenesis. The synthesis of type I collagen (Collagen I) and other extracellular matrix are essential for tendon differentiation and homeostasis. Current studies on tenogenesis focused mostly on the tenogenic... [read more]
Transient microRNA Expression Enhances Myogenic Potential of Mouse Embryonic Stem Cells
January 4, 2018 | rss feed
MicroRNAs (miRNAs) are known regulators of various cellular processes, including pluripotency and differentiation of embryonic stem cells (ESCs). We analyzed differentiation of two ESC lines - D3 and B8, and observed significant differences in the expression of miRNAs and genes involved in... [read more]
Researchers grow hairy skin using mouse stem cells
January 4, 2018 | rss feed
Indiana University School of Medicine researchers have cultured the first lab-grown skin tissue complete with hair... [read more]
A Nestin-Cdk5-Drp1 Axis Regulates Neural Stem/Progenitor Cell Stemness via a Metabolic Shift
January 3, 2018 | rss feed
Neural stem/progenitor cells (NSPCs) transplantation provides an alternative approach for various central nervous system (CNS) diseases treatment, while the difficulties in NSPC acquisition and expansion limit their further application. Unveiling the mechanism of NSPC stemness regulation may... [read more]
Spider’s web inspires new device that could revolutionize management of type 1 diabetes
January 3, 2018 | rss feed
For the more than 1 million Americans who live with type 1 diabetes, daily insulin injections are literally a matter of life and death. And while there is no cure, a Cornell University-led research team has developed a device that could revolutionize... [read more]
Bioengineers reveal how to recreate complex folded shapes from living tissue
December 30, 2017 | rss feed
Many of the complex folded shapes that form mammalian tissues can be recreated with very simple instructions, UC San Francisco bioengineers report December 28 in the journal Developmental... [read more]
Gene therapy with CAR T-cells could create long-term immunity from HIV
December 30, 2017 | rss feed
Through gene therapy, researchers engineered blood-forming stem cells (hematopoietic stem/progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV-infected... [read more]
Cover Image
December 29, 2017 | rss feed
Cover Art: Preservation of human retinal ganglion cells after culture with human mesenchymal stem cells for 7 days in post mortem retinal explants. See Osborne et al. beginning on page... [read more]
In Vitro Modeling of Congenital Heart Defects Associated with an NKX2-5 Mutation Revealed a Dysregulation in BMP/Notch-Mediated Signaling
December 28, 2017 | rss feed
The Nkx2-5 gene codes for a transcription factor that plays a critical role in heart development. Heterozygous mutations in NKX2-5 in both human and mice result in congenital heart defects (CHDs). However, the molecular mechanisms by which these mutations cause the disease are still unknown.... [read more]
Hair Follicle Stem Cell Faith Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation
December 28, 2017 | rss feed
The main function of the skin, to protect against the environment, is supported by the activity of different stem cell populations. The main focus of this study was elucidating the coping mechanisms of stem cells against the stimulation of constant exposure to genotoxic stresses, both endogenous... [read more]
Bmi1+ Progenitor Cell Dynamics in Murine Cornea During Homeostasis and Wound Healing
December 28, 2017 | rss feed
The outermost layer of the eye, the cornea, is renewed continuously throughout life. Stem cells of the corneal epithelium reside in the limbus at the corneal periphery and ensure homeostasis of the central epithelium. However, in young mice, homeostasis relies on cells located in the basal layer of... [read more]
Study highlights pernicious effect of obesity on blood-making stem cells
December 27, 2017 | rss feed
New research published in the Journal of Experimental Medicine highlights the pernicious effect of obesity on the long-term health of blood-making stem cells (hematopoietic stem... [read more]
New approach to sticking bio-ink droplets together enables 3D printing of complex tissues
December 27, 2017 | rss feed
Printed replacement human body parts might seem like science fiction, but this technology is rapidly becoming a reality with the potential to greatly contribute to regenerative medicine. Before any real applications, "bioprinting" still faces many... [read more]
Researchers find progenitor cells for all the heart’s components, except right ventricle
December 26, 2017 | rss feed
Progenitor cells - undifferentiated cells that later become specified - for all the heart's components, except for the right ventricle, have been found by Hiroshima University researchers and detailed in a paper published in Nature... [read more]
A Novel Approach to Single Cell RNA-Sequence Analysis Facilitates In Silico Gene Reporting of Human Pluripotent Stem Cell-Derived Retinal Cell Types
December 26, 2017 | rss feed
Cell type-specific investigations commonly use gene reporters or single-cell analytical techniques. However, reporter line development is arduous and generally limited to a single gene of interest, while single-cell RNA (scRNA)-sequencing (seq) frequently yields equivocal results that preclude... [read more]
Alpha-Klotho Enrichment in Induced Pluripotent Stem Cell Secretome Contributes to Antioxidative Protection in Acute Lung Injury
December 26, 2017 | rss feed
Induced pluripotent stem cells (iPSCs) have been reported to alleviate organ injury, although the mechanisms of action remain unclear and administration of intact cells faces many limitations. We hypothesized that cell-free conditioned media (CM) containing the secretome of iPSCs possess... [read more]
Researchers sequence salamander genome to reveal unique features of regeneration
December 23, 2017 | rss feed
Researchers at Karolinska Institutet in Sweden have managed to sequence the giant genome of a salamander, the Iberian ribbed newt, which is a full six times greater than the human... [read more]
Intercellular Transfer of Microvesicles from Young Mesenchymal Stromal Cells Rejuvenates Aged Murine Hematopoietic Stem Cells
December 22, 2017 | rss feed
Donor age is one of the major concerns in bone marrow transplantation, as the aged hematopoietic stem cells (HSCs) fail to engraft efficiently. Here, using murine system, we show that a brief interaction of aged HSCs with young mesenchymal stromal cells (MSCs) rejuvenates them and restores their... [read more]
Polycystin-2 Plays an Essential Role in Glucose Starvation Induced Autophagy in Human Embryonic Stem Cell Derived Cardiomyocytes
December 22, 2017 | rss feed
Autophagy is a process essential for cell survival under stress condition. The patients with autosomal dominant polycystic kidney disease (ADPKD), which is caused by polycystin-1 (PKD1) or polycystin-2 (PKD2) mutation, display cardiovascular abnormalities and dysregulation in autophagy. However, it... [read more]
Polycystin-2 Plays an Essential Role in Glucose Starvation-Induced Autophagy in Human Embryonic Stem Cell-Derived Cardiomyocytes
December 22, 2017 | rss feed
Autophagy is a process essential for cell survival under stress condition. The patients with autosomal dominant polycystic kidney disease, which is caused by polycystin-1 or polycystin-2 (PKD2) mutation, display cardiovascular abnormalities and dysregulation in autophagy. However, it is unclear... [read more]
Salk scientists find simpler way to derive functioning cardiac cells from stem cells
December 22, 2017 | rss feed
The process by which embryonic stem cells develop into heart cells is a complex process involving the precisely timed activation of several molecular pathways and at least 200... [read more]
Differences in the Activity of Endogenous Bone Morphogenetic Protein Signaling Impact on the Ability of Induced Pluripotent Stem Cells to Differentiate to Corneal Epithelial-Like Cells
December 22, 2017 | rss feed
Cornea is a clear outermost layer of the eye which enables transmission of light onto the retina. The transparent corneal epithelium is regenerated by limbal stem cells (LSCs), whose loss/dysfunction results in LSCs deficiency (LSCD). Ex vivo expansion of autologous LSCs obtained from patient's... [read more]
Loss of specific protein makes breast cancers more aggressive, resistant to chemotherapy
December 21, 2017 | rss feed
Researchers in Italy have discovered how specific versions of a protein called Numb protect the key tumor suppressor p53 from... [read more]
Is chemo at the heart of cancer regrowth?
December 21, 2017 | rss feed
Researchers have discovered that chemotherapy provides the perfect backdrop for 'sleeping' cancer to churn out deadly cancer stem... [read more]
Ecological Balance of Oral Microbiota is Required to Maintain Oral Mesenchymal Stem Cell Homeostasis
December 21, 2017 | rss feed
Oral microbiome is essential for maintenance of oral cavity health. Imbalanced oral microbiome causes periodontal and other diseases. It is unknown whether oral microbiome affect oral stem cells function. In this study, we used a common clinical anti-biotic treatment approach to alter oral... [read more]
Ecological Balance of Oral Microbiota Is Required to Maintain Oral Mesenchymal Stem Cell Homeostasis
December 21, 2017 | rss feed
Oral microbiome is essential for maintenance of oral cavity health. Imbalanced oral microbiome causes periodontal and other diseases. It is unknown whether oral microbiome affect oral stem cells function. This study used a common clinical antibiotic treatment approach to alter oral microbiome... [read more]
Human Mesenchymal Stem Cell Failure to Adapt to Glucose Shortage and Rapidly use Intracellular Energy Reserves through Glycolysis Explains Poor Cell Survival After Implantation
December 21, 2017 | rss feed
Mesenchymal stem cells (MSCs) hold considerable promise in tissue engineering (TE). Their poor survival when exogenously administered, however, limits their therapeutic potential. Previous studies from our group demonstrated that lack of glucose (but not of oxygen) is fatal to human MSCs because it... [read more]
Human Mesenchymal Stem Cell Failure to Adapt to Glucose Shortage and Rapidly Use Intracellular Energy Reserves Through Glycolysis Explains Poor Cell Survival After Implantation
December 21, 2017 | rss feed
Mesenchymal stem cells (MSCs) hold considerable promise in tissue engineering (TE). However, their poor survival when exogenously administered limits their therapeutic potential. Previous studies from our group demonstrated that lack of glucose (glc) (but not of oxygen) is fatal to human MSCs... [read more]
Study findings could lead to less expensive and more effective cancer treatments
December 21, 2017 | rss feed
The latest generation of cancer treatments spring from the discovery that the human immune system is able to beat the disease. Like Dorothy in "The Wizard of Oz," what research teams around the world have spent decades searching for was right in their... [read more]
Stem cells remain healthy following low-dose X-ray exposure, say biophysicists
December 21, 2017 | rss feed
Biophysicists have shown that following low-dose exposure to X-rays (at 80 milligrays), stem cells remain healthy, proliferate, and do not accumulate DNA damage to be passed on to their progeny. The paper was published in the journal... [read more]
Japanese researchers use pluripotent stem cells to reproduce higher-order kidney structures
December 20, 2017 | rss feed
In the embryonic kidney, three types of precursor cells, nephron progenitor cells, ureteric buds, and interstitial progenitor cells, interact to form three-dimensional structures of the... [read more]
Scientists develop test to predict treatment outcomes in patients with childhood leukemia
December 20, 2017 | rss feed
UC San Francisco physician-scientists have developed a test that can predict how patients with juvenile myelomonocytic leukemia (JMML) will respond to treatment, and may also be able to identify patients who are likely to recover spontaneously with... [read more]
Study suggests new treatment option for most lethal form of breast cancer
December 19, 2017 | rss feed
The most lethal form of breast cancer could have a new treatment option, according to new research out of the Case Comprehensive Cancer Center at Case Western Reserve University School of... [read more]
A guide to Severe Combined Immunodeficiency Disease, review released
December 18, 2017 | rss feed
A new review published today in the Canadian Medical Association Journal provides guidance on Severe Combined Immunodeficiency Disease (SCID), a deadly and rare disease that is potentially curable if detected... [read more]
Mature cells also play role in initiating cancer, study suggests
December 18, 2017 | rss feed
Rapidly dividing, yet aberrant stem cells are a major source of cancer. But a new study suggests that mature cells also play a key role in initiating cancer -; a finding that could upend the way scientists think about the origin of the... [read more]
New review provides guidance to doctors who may treat infants with ‘bubble boy disease’
December 18, 2017 | rss feed
A new review provides guidance on a deadly, but rare, disease that is potentially curable if identified early. Severe combined immunodeficiency disease (SCID), known as the "bubble boy disease" in the 1970s, is treatable with a stem cell transplant,... [read more]
Study reveals biology behind why muscle stem cells respond differently to aging or injury
December 16, 2017 | rss feed
A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute describes the biology behind why muscle stem cells respond differently to aging or... [read more]
Extracellular vesicles can be used to effectively delay progression of kidney damage
December 15, 2017 | rss feed
Researchers have demonstrated for the first time that extracellular vesicles - tiny protein-filled structures - isolated from amniotic fluid stem cells (AFSCs) can be used to effectively slow the progression of kidney damage in mice with a type of... [read more]
GVHD amelioration by human bone marrow mesenchymal stromal/stem cell-derived extracellular vesicles is associated with peripheral preservation of naive T cell populations
December 14, 2017 | rss feed
A substantial proportion of patients with acute graft-versus-host disease (aGVHD) respond to cell therapy with culture-expanded human bone marrow mesenchymal stromal/stem cells (BM-MSCs). However, the mechanisms by which these cells can ameliorate aGVHD-associated complications remain to be... [read more]
Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations
December 14, 2017 | rss feed
A substantial proportion of patients with acute graft-versus-host disease (aGVHD) respond to cell therapy with culture-expanded human bone marrow mesenchymal stromal/stem cells (BM-MSCs). However, the mechanisms by which these cells can ameliorate aGVHD-associated complications remain to be... [read more]
Long Noncoding RNA-1604 Orchestrates Neural Differentiation through the miR-200c/ZEB Axis
December 14, 2017 | rss feed
Clarifying the regulatory mechanisms of embryonic stem cell (ESC) neural differentiation is helpful not only for understanding neural development but also for obtaining high-quality neural progenitor cells required by stem cell therapy of neurodegenerative diseases. Here, we found that long... [read more]
Single Cell Resolution of Human Hematoendothelial Cells Defines Transcriptional Signatures of Hemogenic Endothelium
December 14, 2017 | rss feed
Endothelial-to-hematopoietic transition (EHT) is an important stage in definitive hematopoietic development. However, the genetic mechanisms underlying human EHT remain poorly characterized. We performed single cell RNA-seq using 55 hemogenic endothelial cells (HECs:... [read more]
Study finds barriers to stem cell transplant use among multiple myeloma patients from minority groups
December 13, 2017 | rss feed
A study by researchers at Mayo Clinic's campus in Jacksonville, Florida has found that barriers to patients receiving stem cell therapy as part of their treatment for multiple myeloma include income, education, insurance status and access to care at... [read more]
Study reveals impact of diabetes during pregnancy on baby’s heart
December 13, 2017 | rss feed
A new study conducted at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA discovered how increased glucose levels caused either by diabetes or other factors keep heart cells from maturing... [read more]
Concise Review: Human Pluripotent Stem Cells to Produce Cell-Based Cancer Immunotherapy
December 13, 2017 | rss feed
Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These... [read more]
Human Pluripotent Stem Cells to Produce Cell-based Cancer Immunotherapy
December 13, 2017 | rss feed
Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These... [read more]
Concise review: The Cellular Conspiracy of ALS
December 13, 2017 | rss feed
Amyotrophic lateral sclerosis (ALS) is incurable and devastating. A dearth of therapies has galvanized experimental focus onto the cellular and molecular mechanisms that both initiate and subsequently drive motor neuron (MN) degeneration. A traditional view of ALS pathogenesis posits that... [read more]
Concise Review: The Cellular Conspiracy of Amyotrophic Lateral Sclerosis
December 13, 2017 | rss feed
Amyotrophic lateral sclerosis (ALS) is incurable and devastating. A dearth of therapies has galvanized experimental focus onto the cellular and molecular mechanisms that both initiate and subsequently drive motor neuron degeneration. A traditional view of ALS pathogenesis posits that... [read more]
The gp130 Cytokine IL-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients
December 13, 2017 | rss feed
During bone marrow transplantation (BMT), hematopoietic stem and progenitor cells (HSPCs) respond to signals from the hematopoietic microenvironment (HM) by coordinately activating molecular pathways through Rho GTPases, including Rac. We have previously shown that deletion of Vav1, a... [read more]
The gp130 Cytokine Interleukin-11 Regulates Engraftment of Vav1–/– Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients
December 13, 2017 | rss feed
During bone marrow transplantation, hematopoietic stem and progenitor cells (HSPCs) respond to signals from the hematopoietic microenvironment by coordinately activating molecular pathways through Rho GTPases, including Rac. We have previously shown that deletion of Vav1, a hematopoietic-specific... [read more]
Adaptation of the Bone Marrow Stroma in Hematopoietic Malignancies – Current Concepts and Models
December 13, 2017 | rss feed
The bone marrow stroma maintains hematopoiesis and coordinately regulates regenerative responses through dynamic interactions with hematopoietic stem and progenitor cells. Recent studies indicate that stromal components in the bone marrow of leukemia patients undergo a process of successive... [read more]
Concise Review: Adaptation of the Bone Marrow Stroma in Hematopoietic Malignancies: Current Concepts and Models
December 13, 2017 | rss feed
The bone marrow stroma maintains hematopoiesis and coordinately regulates regenerative responses through dynamic interactions with hematopoietic stem and progenitor cells. Recent studies indicate that stromal components in the bone marrow of leukemia patients undergo a process of successive... [read more]
Researchers discover how high glucose levels in pregnancy affect baby’s heart
December 13, 2017 | rss feed
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered how high glucose levels -- whether caused by diabetes or other factors -- keep heart cells from maturing... [read more]
Delta-Like 4 Activates Notch 3 to Regulate Self-Renewal in Skeletal Muscle Stem Cells
December 12, 2017 | rss feed
Notch signaling is essential to maintain skeletal muscle stem cells in quiescence. However, the precise roles of different Notch receptors are incompletely defined. Here, we demonstrate a role for Notch3 (N3) in the self-renewal of muscle stem cells. We found that N3 is active in quiescent C2C12... [read more]
Delta-like 4 Activates Notch3 to Regulate Self-Renewal in Skeletal Muscle Stem Cells
December 12, 2017 | rss feed
Notch signalling is essential to maintain skeletal muscle stem cells in quiescence. The precise roles of the different Notch receptors are, however, incompletely defined. Here we demonstrate a role for Notch3 in the self-renewal of muscle stem cells. We found that Notch3 is active in quiescent... [read more]
Intercellular Transfer of Microvesicles from Young Mesenchymal Stromal Cells Rejuvenates Aged Murine Hematopoietic Stem Cells
December 12, 2017 | rss feed
Donor age is one of the major concerns in bone marrow transplantation, as the aged hematopoietic stem cells (HSCs) fail to engraft efficiently. Here, using murine system, we show that a brief interaction of aged HSCs with young mesenchymal stromal cells (MSCs) rejuvenates them and restores their... [read more]
A Novel Approach to Single Cell RNA-Sequence Analysis Facilitates In Silico Gene Reporting of Human Pluripotent Stem Cell-Derived Retinal Cell Types
December 12, 2017 | rss feed
Cell type-specific investigations commonly use gene reporters or single-cell analytical techniques. However, reporter line development is arduous and generally limited to a single gene of interest, while single-cell RNA (scRNA)-sequencing (seq) frequently yields equivocal results that preclude... [read more]
Genentech researchers uncover epigenetic regulator of pancreatic cancer cells
December 12, 2017 | rss feed
Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells'... [read more]
Study provides new insights into mechanism of tumor survival in glioblastoma
December 12, 2017 | rss feed
A Northwestern Medicine study, published in the journal Cancer Cell, has provided new insights into a mechanism of tumor survival in glioblastoma and demonstrated that inhibiting the process could enhance the effects of radiation... [read more]
Scientists develop software that predicts leukemia-specific immune targets
December 11, 2017 | rss feed
University of North Carolina Lineberger Comprehensive Cancer Center scientists have developed a software program that can accurately predict which tumor-specific markers will show up on the surface of leukemia cells in patients who have received stem... [read more]
Pairing immunotherapy drug with chemotherapy proves beneficial for relapsed acute myeloid leukemia
December 11, 2017 | rss feed
University of North Carolina Lineberger Comprehensive Cancer Center researchers report that pairing an immunotherapy drug with chemotherapy proved beneficial for some patients with acute myeloid leukemia whose disease did not respond to standard... [read more]
St. Jude gene therapy offers hope for infants with ‘bubble boy’ disease
December 11, 2017 | rss feed
Early evidence suggests that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency... [read more]
St. Jude gene therapy offers hope for infants with ‘bubble boy’ disease
December 11, 2017 | rss feed
Early evidence suggests that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency... [read more]
Differences in the Activity of Endogenous Bone Morphogenetic Protein Signaling Impact on the Ability of Induced Pluripotent Stem Cells to Differentiate to Corneal Epithelial-Like Cells
December 11, 2017 | rss feed
Cornea is a clear outermost layer of the eye which enables transmission of light onto the retina. The transparent corneal epithelium is regenerated by limbal stem cells (LSCs), whose loss/dysfunction results in LSCs deficiency (LSCD). Ex vivo expansion of autologous LSCs obtained from patient's... [read more]
Alpha-Klotho Enrichment in Induced Pluripotent Stem Cell Secretome Contributes to Antioxidative Protection in Acute Lung Injury
December 11, 2017 | rss feed
Induced pluripotent stem cells (iPSCs) have been reported to alleviate organ injury, although the mechanisms of action remain unclear and administration of intact cells faces many limitations. We hypothesized that cell-free conditioned media (CM) containing the secretome of iPSCs possess... [read more]
Cell Therapy for Critical Limb Ischemia: An Integrated Review of Pre-clinical and Clinical Studies
December 11, 2017 | rss feed
Critical limb ischemia (CLI), the most severe form of peripheral artery disease, is characterized by pain at rest and non-healing ulcers in the lower extremities. For patients with CLI, where the extent of atherosclerotic artery occlusion is too severe for surgical bypass or percutaneous... [read more]

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